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tweaking the immune system as an adjuvant for the treatment of retinal degenerations

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Annals of Eye Science 2017年第1期2卷 53-56页

作者： tiago Santos-Ferreira Marius Ader technische Universität dresden Center for Regenerative Therapies Dresden(CRTD)DresdenGermany

Blinding diseases such as photoreceptor degenerations are debilitating conditions that severely impair daily lives of affected *** group of diseases are amenable to photoreceptor replacement therapies and recent transplantation studies provided proof-of-principle for functional recovery at the retinal and behavioral level,though the actual mechanism of repair still needs further *** immune system responds in several ways upon photoreceptor engraftment,resulting in t-cell and macrophage infiltrations and,consequently,decrease in graft *** studies on the role of the immune system suggest a detrimental effect in a therapeutic ***,the opposite idea wherein the immune system can be activated towards a protective state was also explored in other experimental ***,Neves and colleagues explored the potential of cross-species studies and,to a certain extent,the concept of a protective immune system in retinal degeneration and *** astrocyte-derived neurotrophic factor(MANF)was identified in this study as a novel factor that,by modulating the immune system,can slow down photoreceptor degeneration and improve transplantation outcome.

关键词： Immune modulation retina retinal degeneration photoreceptor transplantation retinal repair

Perspective towards atomic-resolution imaging of two-dimensional polymers

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SmartMat 2021年第2期2卷 131-138页

作者： Haoyuan Qi Baokun Liang Ute Kaiser Central Facility of Electron Microscopy Electron Microscopy Group of Materials ScienceUniversität UlmUlmGermany Center for Advancing Electronics dresden(cfaed) Faculty of Chemistry and Food ChemistryTechnische Universität DresdenDresdenGermany

Recent years have witnessed the rise of an emerging class of synthetic twodimensional(2D)materials-2D *** combination of organic chemistry and rational design of polymeric crystals has stimulated tremendous research efforts in the controlled synthesis of 2D ***,despite the advancement in synthetic methodologies,the structural characterization of 2D polymers remains a significant *** aberration-corrected high-resolution transmission electron microscopy(AC-HRtEM)is capable of direct imaging of atomic structures with sub-Ångström resolution,electron radiation damage poses a substantial limit on the achievable image resolution due to instant decomposition of the molecular *** this Perspective,we will briefly discuss radiation damage mitigation strategies,which may eventually result in AC-HRtEM imaging of 2D polymers down to the atomic scale.

关键词： covalent organic frameworks transmission electron microscopy two-dimensional polymers

Production of highly charged argon ions from a room temperature electron beam ion trap

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Chinese Physics C 2008年第5期32卷 389-392页

作者：王铁山彭海波 Ovsyannikov V P Kentsch U Ullmann F 程锐 Zschornack G School of Nuclear Science and technology Lanzhou UniversityLanzhou 730000China DREEBIt GmbH Zur Wetterwarte 50D-01109 DresdenGermany technische Universitt dresden Institute of Applied PhysicsDresden D-01069Germany

In this work, highly charged ions have been extracted from the advanced Electron Beam Ion Source （EBIS-A） developed in a scientific cooperation between the dresden University of technology and the DREEBIt GmbH dresden. the charge state distributions of ions extracted from the EBIS-A are measured in the pulse and leaky modes under different operation conditions. Aris＋ ions with current of 2 pA are produced and extracted in the leaky mode. 3×10^5 Ar^18＋ ions per pulse are extracted in the pulse mode. the ion charge state distribution is a function of the ionization time.

关键词： EBIS highly charged ion ionization time

Ab initio density response and local field factor of warm dense hydrogen

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Matter and Radiation at Extremes 2024年第5期9卷 48-67页

作者： tobias Dornheim Sebastian Schwalbe Panagiotis tolias Maximilian P.Böhme Zhandos A.Moldabekov Jan Vorberger Center for Advanced Systems Understanding(CASUS) D-02826 GörlitzGermany Helmholtz-Zentrum dresden-Rossendorf(HZDR) D-01328 DresdenGermany Space and Plasma Physics Royal Institute of Technology(KTH)Stockholm SE-10044Sweden technische Universität dresden D-01062 DresdenGermany

We present quasi-exact ab initio path integral Monte Carlo(PIMC)results for the partial static density responses and local field factors of hydrogen in the warm dense matter regime,from solid density conditions to the strongly compressed *** full dynamic treatment of electrons and protons on the same footing allows us to rigorously quantify both electronic and ionic exchange–correlation effects in the system,and to compare the results with those of earlier incomplete models such as the archetypal uniform electron gas or electrons in a fixed ion snapshot potential that do not take into account the interplay between the two *** full electronic density response is highly sensitive to electronic localization around the ions,and our results constitute unambiguous predictions for upcoming X-ray thomson scattering experiments with hydrogen jets and fusion *** PIMC results are made freely available and can be used directly for a gamut of applications,including inertial confinement fusion calculations and the modeling of dense astrophysical ***,they constitute invaluable benchmark data for approximate but computationally less demanding approaches such as density functional theory or PIMC within the fixed-node approximation.

关键词： local incomplete rigorous

Novel Design Solutions for Fishing Reel Mechanisms

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 726-736页

作者： LOVASZ Erwin-Christian MODLER Karl-Heinz NEUMANN Rudolf GRUESCU Corina Mihaela PERJU Dan CIUPE Valentin MANIU Inocentiu Department of Mechatronics University Politehnica Timisoara Institut für Festkrpermechanik Technische Universitt Dresden

Currently, there are various reels on the market regarding the type of mechanism, which achieves the winding and unwinding of the line. the designers have the purpose of obtaining a linear transmission function, by means of a simple and small-sized mechanism. However, the present solutions are not satisfactory because of large deviations from linearity of the transmission function and complexity of mechanical schema. A novel solution for the reel spool mechanism is proposed. Its kinematic schema and synthesis method are described. the kinematic schema of the chosen mechanism is based on a noncircular gear in series with a scotch-yoke mechanism. the yoke is driven by a stud fixed on the driving noncircular gear. the drawbacks of other models regarding the effects occurring at the ends of the spool are eliminated through achieving an appropriate transmission function of the spool. the linear function approximation with curved end-arches appropriately computed to ensure mathematical continuity is very good. the experimental results on the mechanism model validate the theoretical approach. the developed mechanism solution is recorded under a reel spool mechanism patent.

关键词： reel mechanism noncircular gears analysis synthesis transmission function

Development of a classification system based on corneal biomechanical properties using artificial intelligence predicting keratoconus severity

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Eye and Vision 2021年第3期8卷 203-213页

作者： Robert Herber Lutz E.Pillunat Frederik Raiskup Department of Ophthalmology University Hospital Carl Gustav CarusUniversitätsklinikum Carl Gustav Carus an der Technischen Universität DresdenFetscherstraße 74TU 01307 DresdenGermany

Background:to investigate machine-learning(ML)algorithms to differentiate corneal biomechanical properties between different topographical stages of keratoconus(KC)by dynamic Scheimpflug tonometry(CSt,Corvis St,Oculus,Wetzlar,Germany).In the following,ML models were used to predict the severity in a training and validation ***:three hundred and eighteen keratoconic and one hundred sixteen healthy eyes were included in this monocentric and cross-sectional pilot *** corneal response(DCR)and corneal thickness related(pachymetric)parameters from CSt were chosen by appropriated selection techniques to develop a ML *** stage of KC was determined by the topographical keratoconus classification system(tKC,Pentacam,Oculus).Patients who were classified as tKC 1,tKC 2 and tKC 3 were assigned to subgroup mild,moderate,and advanced *** patients were classified as tKC 1-2,tKC 2-3 or tKC 3-4,they were assigned to subgroups according to the normative range of further corneal indices(index of surface variance,keratoconus index and minimum radius).Patients classified as tKC 4 were not included in this study due to the limited amount of *** discriminant analysis(LDA)and random forest(RF)algorithms were used to develop the classification *** were divided into training(70%of cases)and validation(30%of cases)***:LDA model predicted healthy,mild,moderate,and advanced KC eyes with a sensitivity(S_(n))/specificity(S_(p))of 82%/97%,73%/81%,62%/83%and 68%/95%from a validation dataset,*** the RF model,a S_(n)/S_(p) of 91%/94%,80%/90%,63%/87%,72%/95%could be reached for predicting healthy,mild,moderate,and advanced KC eyes,*** overall accuracy of LDA and RF was 71%and 78%,*** accuracy for KC detection including all subgroups of KC severity was 93%in both ***:the RF model showed good accuracy in predicting healthy eyes and various stages of *** accuracy was superior with respec

关键词： Artificial intelligence Corneal biomechanics Corvis St Grading Keratoconus Machine learning

Schottky barrier-based silicon nanowire pH sensor with live sensitivity control

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Nano Research 2014年第2期7卷 263-271页

作者： Felix M. Zorgiebel Sebastian Pregl Lotta Romhildtt Jorg Opitz W. Weber t. Mikolajick Larysa Baraban Gianaurelio Cuniberti Institute for Materials Science and Max Bergmann Center ofBiomaterials TU Dresden 01062 Dresden Germany NaMLab GmbH 01187 Dresden Germany Fraunhofer Institute IZFP dresden 01109 Dresden Germany Institute for Semiconductors and Microsystems technology TU Dresden 01187 Dresden Germany dresden Germany Center forAdvancing Electronics Dresden TU Dresden 01062 Dresden Germany

We demonstrate a pH sensor based on ultrasensitive nanosize Schottky junctions formed within bottom-up grown dopant-flee arrays of assembled silicon nanowires. A new measurement concept relying on a continuous gate sweep is presented, which allows the straightforward determination of the point of maximum sensitivity of the device and allows sensing experiments to be performed in the optimum regime. Integration of devices into a portable fluidic system and an electrode isolation strategy affords a stable environment and enables long time robust FEt sensing measurements in a liquid environment to be carried out. Investigations of the physical and chemical sensitivity of our devices at different pH values and a comparison with theoretical limits are also discussed. We believe that such a combination of nanofabrication and engineering advances makes this Schottky barrier-powered silicon nanowire lab-on-a-chip platform suitable for efficient biodetection and even for more complex biochemical analysis.

关键词： silicon nanowires field effect transistor sub-threshold regime nanosensors pH sensor bottom-up fabrication maximum sensitivity ofsensor

three-dimensional acoustic monitoring of laser-accelerated protons in the focus of a pulsed-power solenoid lens

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High Power Laser Science and Engineering 2023年第3期11卷 57-63页

作者： S.Gerlach F.Balling A.K.Schmidt F.E.Brack F.Kroll J.Metzkes-Ng M.Reimold U.Schramm M.Speicher K.Zeil K.Parodi J.Schreiber Fakultät für Physik Ludwig-Maximilians-Universität MünchenGarchingGermany Helmholtz-Zentrum dresden-Rossendorf DresdenGermany technische Universität dresden DresdenGermany

the acoustic pulse emitted from the Bragg peak of a laser-accelerated proton bunch focused into water has recently enabled the reconstruction of the bunch energy *** adding three ultrasonic transducers and implementing a fast data analysis of the filtered raw signals,I-BEAt(Ion-Bunch Energy Acoustic tracing)3D now provides the mean bunch energy and absolute lateral bunch position in real-time and for individual *** changes in energy spread and lateral bunch size can also be *** experiments at DRACO with proton bunch energies between 10 and 30 MeV reveal sub-MeV and sub-mm *** addition to this 3D bunch information,the signal strength correlates also with the absolute bunch particle number.

关键词： ion diagnostics ionoacoustics laser-driven plasma source laser-ion acceleration

Optimal control of automated left-turn platoon at contraflow left-turn lane intersections

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Journal of Intelligent and Connected Vehicles 2022年第3期5卷 206-214页

作者： Hanyu Yang Jing Zhao Meng Wang Department of traffic Engineering University of Shanghai for Science and TechnologyShanghaiChina Chair of traffic Process Automation Technische Universität DresdenDresdenGermany

Purpose–this study aims to propose a centralized optimal control model for automated left-turn platoon at contraflow left-turn lane(CLL)***/methodology/approach–the lateral lane change control and the longitudinal acceleration in the control horizon are optimized simultaneously with the objective of maximizing traffic efficiency and *** proposed model is cast into a mixed-integer linear programming problem and then solved by the branch-and-bound ***–the proposed model has a promising control effect under different geometric controlled ***,the proposed model performs robustly under various safety time headways,lengths of the CLL and green times of the main ***/value–this study proposed a centralized optimal control model for automated left-turn platoon at CLL *** lateral lane change control and the longitudinal acceleration in the control horizon are optimized simultaneously with the objective of maximizing traffic efficiency and smoothness。

关键词： Contraflow left-turn lane intersections Automated vehicle platoon Optimal control Vehicular trajectory Automated vehicles Connected vehicles Cooperative intelligence Following control Vehicle-to-vehicle communication(V2V)