Tweaking the immune system as an adjuvant for the treatment of retinal degenerations
作者机构：Technische Universität DresdenCenter for Regenerative Therapies Dresden(CRTD)DresdenGermany
出 版 物：《Annals of Eye Science》 (眼科学年鉴（英文）)
年 卷 期：2017年第2卷第1期
页 面：53-56页
学科分类：1002[医学-临床医学] 08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）]
基 金：Center for Regenerative Therapies Dresden, Cluster of Excellence, (AD375/3-1) ProRetina Stiftung Deutsche Forschungsgemeinschaft, DFG, (FZT 111) o r k w a s s u p p o r t e d b y t h e Deutsche Forschungsgemeinschaft
主 题：Immune modulation retina retinal degeneration photoreceptor transplantation retinal repair
摘 要：Blinding diseases such as photoreceptor degenerations are debilitating conditions that severely impair daily lives of affected *** group of diseases are amenable to photoreceptor replacement therapies and recent transplantation studies provided proof-of-principle for functional recovery at the retinal and behavioral level,though the actual mechanism of repair still needs further *** immune system responds in several ways upon photoreceptor engraftment,resulting in T-cell and macrophage infiltrations and,consequently,decrease in graft *** studies on the role of the immune system suggest a detrimental effect in a therapeutic ***,the opposite idea wherein the immune system can be activated towards a protective state was also explored in other experimental ***,Neves and colleagues explored the potential of cross-species studies and,to a certain extent,the concept of a protective immune system in retinal degeneration and *** astrocyte-derived neurotrophic factor(MANF)was identified in this study as a novel factor that,by modulating the immune system,can slow down photoreceptor degeneration and improve transplantation outcome.
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