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Rapid increase in numbers and change of land-use in two expanding Columbidae species(Columba palumbus and Streptopelia decaocto)in Algeria

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Chinese Birds 2015年第4期6卷 246-254页

作者： Djamel Bendjoudi Jean-Francois Voisin Salaheddine Doumandji Amel Merabet Nassima Benyounes Haroun Chenchouni department of biology of Populations and Organisms Faculty of Natural and Life SciencesUniversity of Blida Muséum National d’Histoire Naturelle department of Agricultural and Forestry Zoology National Superior School of Agronomy(ENSA)-El Harrach department of biology Faculty of SciencesUniversity of M’Hamed Bougara department of Natural and Life sciences Faculty of Exact Sciences and Natural and Life SciencesUniversity of Tebessa department of Natural and Life sciences Faculty of SciencesUniversity of El Hadj Lakhdar

Background: Investigating population ecology of urban bird species,particularly the invasive and expending spe?cies,is the key for the success of urban management and planning ***: Populations of two Columbidae species,the Woodpigeon(Columba palumbus) and the Eurasian Collared Dove(Streptopelia decaocto),were monitored from 1992 to 2010 in the Algiers Sahel,the Mitidja Plain and surround?ing areas(Northern Algeria).Monitoring of species densities was performed by the mapping?plot *** foraging flight routes of Woodpigeon and the distribution of Eurasian Collared Dove were assessed by systematic ***: The number of counted birds was statistically constant at first years of the survey,and then increased sig?nificantly,beginning from low numbers,their densities accelerated sharply between 2001 and 2006,then reached to an equilibrium *** significant increase in Woodpigeon's population could be explained by the reduced hunt?ing pressure and by species adaptation to new food resources provided by nearby ***,monitoring of flight directions of the species revealed the use of agricultural landscapes and habitats,which is a good indicator explaining adaptation and trophic niche of the *** occurrence of the Eurasian Collared Dove in Algiers began in *** density experienced a rapid increase with similar trend pattern as that of *** distributional range is confined mainly in suburban environments of the Mitidja ***: The modifications of habitats,urbanization increase and the lessening of hunting in the Mitidja Plain facilitated the rapid expansion of the Eurasian Collared Dove and Woodpigeon as well contributed to the increase in their numbers over time.

关键词： Columba palumbus Flight routes Mitidja plain Population dynamics Streptopelia decaocto

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Regulation of the timing of oligodendrocyte differentiation:mechanisms and perspectives

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Neuroscience Bulletin 2013年第2期29卷 155-164页

作者： Hao Huang Xiao-Feng Zhao Kang Zheng Mengsheng Qiu Institute of Developmental and Regenerative biology College of Life SciencesHangzhou Normal University department of Anatomical sciences and Neurobiology University of Louisville

Axonal myelination is an essential process for normal functioning of the vertebrate central nervous system. Proper formation of myelin sheaths around axons depends on the timely differentiation of oligodendrocytes. This differentiation occurs on a predictable schedule both in culture and during development. However, the timing mechanisms for oligodendrocyte differentiation during normal development have not been fully uncovered. Recent studies have identified a large number of regulatory factors, including cell-intrinsic factors and extracel- lular signals, that could control the timing of oligodendrocyte differentiation. Here we provide a mechanistic and critical review of the timing control of oligodendrocyte differentiation.

关键词： oligodendrocytes differentiation timing remyelination

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Magnetic Field Intensity/Melatonin-Molarity Interactions: Experimental Support with Planarian (Dugesia sp.) Activity for a Resonance-Like Process

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Open Journal of Biophysics 2012年第4期2卷 137-143页

作者： Bryce P. Mulligan Noa Gang Glenn H. Parker Michael A. Persinger department of biology Behavioural Neuroscience Program department of biology Behavioural Neuroscience Program Biomolecular Sciences Program Laurentian UniversitySudbury Canada department of biology Behavioural Neuroscience ProgramBiomolecular Sciences Program Laurentian UniversitySudbury Canada

Synergistic interactions between specific magnetic field intensities and chemical concentrations are challenging biophysical phenomena. Planarian were exposed to one of five different concentrations of melatonin and to a “geomagnetic”—patterned 7 Hz amplitude modulated magnetic field for 6 min once per hour for 8 hr during six successive nights. The peak average strengths were within the range (50 nT) or outside the range (200 nT) derived by the equation. As predicted by a resonance equation planarian displayed highly statistically significant decreased relative activity within the 50 nT, 10–7 to 10–6 M melatonin conditions compared to lower or higher concentrations. The effect explained about 30% of the variance in these changes of activity. Activity of planarian exposed to the same melatonin concentrations but to the 200 nT field did not differ significantly from each other or from those exposed to the 50 nT field in concentrations of melatonin –7 M or >10–6 M. These results suggest the existence of non-linear, “narrow-band” mechanisms involving the numbers of molecules within a distance determined by the boundary of the organism and the intensity of naturally-patterned magnetic fields derived from energy rather than force-based resonances.

关键词： Resonance Planarian Melatonin Magnetic Fields 7 Hz

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Modeling the causal regulatory network by integrating chromatin accessibility and transcriptome data

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National Science Review 2016年第2期3卷 240-251页

作者： Yong Wang Rui Jiang Wing Hung Wong department of Statistics Department of Biomedical Data ScienceBio-X ProgramStanford University Academy of Mathematics and Systems Science National Center for Mathematics and Interdisciplinary SciencesChinese Academy of Sciences MOE Key Laboratory of Bioinformatics Bioinformatics Division and Center for Synthetic and Systems BiologyTNLISTDepartment of AutomationTsinghua University

Cell packs a lot of genetic and regulatory information through a structure known as chromatin,*** is wrapped around histone proteins and is tightly packed in a remarkable *** express a gene in a specific coding region,the chromatin would open up and DNA loop may be formed by interacting enhancers and ***,the mediator and cohesion complexes,sequence-specific transcription factors,and RNA polymerase Ⅱ are recruited and work together to elaborately regulate the expression *** is in pressing need to understand how the information,about when,where,and to what degree genes should be expressed,is embedded into chromatin structure and gene regulatory *** to large consortia such as Encyclopedia of DNA Elements(ENCODE) and Roadmap Epigenomic projects,extensive data on chromatin accessibility and transcript abundance are available across many tissues and cell *** rich data offer an exciting opportunity to model the causal regulatory ***,we will review the current experimental approaches,foundational data,computational problems,interpretive frameworks,and integrative models that will enable the accurate interpretation of regulatory ***,we will discuss the efforts to organize,analyze,model,and integrate the DNA accessibility data,transcriptional data,and functional genomic regions *** believe that these efforts will eventually help us understand the information flow within the cell and will influence research directions across many fields.

关键词： gene regulatory network open chromatin DNA accessibility transcription factor colocalization statistical model data integration

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Regulation of tumor angiogenesis by the microtubule-binding protein CLIP-170

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Protein & Cell 2013年第4期4卷 266-276页

作者： Xiaodong Sun Fang Li Bin Dong Shaojun Suo Min Liu Dengwen Li Jun Zhou department of Genetics and Cell biology College of Life SciencesNankai UniversityTianjin 300071China

Angiogenesis,the expansion of preexisting blood vessels,is a complex process required for tumor growth and *** current antiangiogenic strategies have shown promising results in several cancer types,identification of additional antiangiogenic targets is required to improve the therapeutic ***,we show that the microtubule-binding protein CLIP-170(cytoplasmic linker protein of 170 kDa)is highly expressed in breast tumor samples and correlates positively with blood vessel *** of CLIP-170 signifi cantly impaired vascular endothelial tube formation and sprouting in vitro and inhibited breast tumor growth in mice by decreasing tumor *** data further show that CLIP-170 is important for the migration but not the proliferation of vascular endothelial *** addition,CLIP-170 promotes the polarization of endothelial cells in response to the angiogenic *** fi ndings thus demonstrate a critical role for CLIP-170 in tumor angiogenesis and suggest its potential as a novel antiangiogenic target.

关键词： tumor angiogenesis endothelial cell migration polarization microtubule

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Cell-specific mineralocorticoid receptors:future therapeutic targets for stroke?

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Neural Regeneration Research 2016年第8期11卷 1230-1231页

作者： Quynh N.Dinh Grant R.Drummond Christopher G.Sobey Sophocles Chrissobolis Vascular biology & Immunopharmacology Group Cardiovascular Disease Program and Department of PharmacologyBiomedicine Discovery InstituteMonash University department of Pharmaceutical and Biomedical sciences Raabe College of PharmacyOhio Northern University

The mineralocorticoid receptor（MR）,well known to be expressed in renal epithelial cells where it is important in fluid and electrolyte homeostasis,has aldosterone as one of its main *** research in the last 10–15 years indicates that MRs are also expressed outside of the kidney,including in the brain,vasculature and heart,where they contribute to the pathophysiology of disease（Dinh et al.,2012;]aisser and Farman, 2016）.

关键词： aldosterone homeostasis electrolyte outside inflammation deletion neurological protective infarct remodeling

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Micro RNAs: Novel immunotherapeutic targets in colorectal carcinoma

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World Journal of Gastroenterology 2016年第23期22卷 5317-5331页

作者： Xiang Li Jing Nie Qian Mei Wei-Dong Han department of Molecular biology School of Life SciencesChinese PLA General Hospital

Colorectal carcinoma(CRC) is one of the most common types of cancer worldwide and the prognosis for CRC patients with recurrence or metastasis is extremely poor. Although chemotherapy and radiation therapy can improve survival, there are still numerous efforts to be performed. Immunotherapy is frequently used, either alone or in combination with other therapies, for the treatment of CRC and is a safe and feasible way to improve CRC treatment. Furthermore, the significance of the immune system in the biology of CRC has been demonstrated by retrospective assessments of immune infiltrates in resected CRC tumors. Micro RNAs(mi RNAs) are short, non-coding RNAs that can regulate multiple target genes at the post-transcriptional level and play critical roles in cell proliferation, differentiation and apoptosis. Mi RNAs are required for normal immune system development and function. Nevertheless, aberrant expression of mi RNAs is often observed in various tumor types and leads to immune disorders or immune evasion. The immunomodulatory function of mi RNAs indicates that mi RNAs may ultimately be part of the portfolio of anti-cancer targets. Herein, we will review the potential roles of mi RNAs in the regulation of the immune response in CRC and then move on to discuss how to utilize different mi RNA targets to treat CRC. We also provide an overview of the major limitations and challenges of using mi RNAs as immunotherapeutic targets.

关键词： Colorectal carcinoma microRNAs Tumor microenvironment Immunotherapy Inflammation Inflammatory bowel disease Immune response

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Computational Analysis of Cysteine Proteases(Clan CA,Family C1) of Leishmania major to Find Potential Epitopic Regions

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Genomics, Proteomics & Bioinformatics 2009年第3期7卷 87-95页

作者： Babak Saffari Hassan Mohabatkar department of biology College of SciencesShiraz UniversityShirazIran

Leishmania is associated with a broad spectrum of diseases, ranging from simple cutaneous to invasive visceral leishmaniasis. Here, the sequences of ten cysteine proteases of types A, B and C of Leishmania major were obtained from GeneDB database. Prediction of MHC class I epitopes of these cysteine proteases was performed by NetCTL program version 1.2. In addition, by using BcePred server, different structural properties of the proteins were predicted to find out their potential B cell epitopes. According to this computational analysis, nine regions were predicted as B cell epitopes. The results provide useful information for designing peptide-based vaccines.

关键词： bioinformatics,cysteine protease T cell epitope B cell epitope Leishmania major

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Structural and biochemical studies of RIG-I antiviral signaling

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Protein & Cell 2013年第2期4卷 142-154页

作者： Miao Feng Zhanyu Ding Liang Xu Liangliang Kong Wenjia Wang Shi Jiao Zhubing Shi Mark IGreene Yao Cong Zhaocai Zhou State Key Laboratory of Cell biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Molecular biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China department of Pathology and Laboratory Medicine University of PennsylvaniaPA 19104USA

Retinoic acid-inducible gene I(RIG-I)is an important pattern recognition receptor that detects viral RNA and triggers the production of type-I interferons through the downstream adaptor MAVS(also called IPS-1,CARDIF,or VISA).A series of structural studies have elaborated some of the mechanisms of dsRNA recognition and activation of *** studies have proposed that K63-linked ubiquitination of,or unanchored K63-linked polyubiquitin binding to RIG-I positively regulates MAVS-mediated antiviral *** phos-phorylation of RIG-I appears to play an inhibitory role in controlling RIG-I antiviral signal *** we performed a combined structural and biochemical study to further define the regulatory features of RIG-I *** and dsRNA binding triggered dimeriza-tion of RIG-I with conformational rearrangements of the tandem CARD *** length RIG-I appeared to form a complex with dsRNA in a 2:2 molar ***-pared with the previously reported crystal structures of RIG-I in inactive state,our electron microscopic struc-ture of full length RIG-I in complex with blunt-ended dsRNA,for the first time,revealed an exposed active conformation of the CARD ***,we found that purified recombinant RIG-I proteins could bind to the CARD domain of MAVS independently of dsRNA,while S8E and T170E phosphorylation-mimick-ing mutants of RIG-I were defective in binding E3 ligase TRIM25,unanchored K63-linked polyubiquitin,and MAVS regardless of *** findings suggested that phosphorylation of RIG inhibited downstream signaling by impairing RIG-I binding with polyubiquitin and its interaction with MAVS.

关键词： RIG-I MAVS antiviral signaling polyubiq-uitin phosphorylation

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Perspectives on the role of Pannexin 1 in neural precursor cell biology

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Neural Regeneration Research 2016年第10期11卷 1540-1544页

作者： Juan C.Sanchez-Arias Leigh E.Wicki-Stordeur Leigh Anne Swayne Division of Medical sciences University of Victoria Island Medical program and department of Cellular and Physiological sciences University of British Columbia

We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous studies on Pannexin 1 in neural precursors as well as the close rela- tionship between Pannexin 1 and purinergic receptors established by other groups. Moreover, we identify important gaps in our understanding of Pannexin 1 in neural precursor cell biology in terms of the under- lying molecular mechanisms and functional/behavioural outcomes.

关键词： neural precursor ventricular zone pannexin ATP cytoskeleton proliferation phagoptosis

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