Perspectives on the role of Pannexin 1 in neural precursor cell biology

作     者：Juan C.Sanchez-Arias Leigh E.Wicki-Stordeur Leigh Anne Swayne 

作者机构：Division of Medical Sciences University of Victoria Island Medical Program and Department of Cellular and Physiological Sciences University of British Columbia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第10期

页      面：1540-1544页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：Research in the Swayne lab was supported by operating grants to LAS from the Natural Sciences and Engineering Research Council of Canada(NSERC Discovery Grant) the Canadian Institutes of Health Research(CIHR Grant MOP142215) The Scottish Rite Charitable Foundation of Canada and the University of Victoria Division of Medical Sciences by infrastructure grants from the Canadian Foundation for Innovation(CFI) the British Columbia Knowledge Development Fund(BCKDF) supported by a Michael Smith Foundation for Health Research and British Columbia Schizophrenia Society Foundation Scholar Award supported by a University of Victoria Fellowship Graduate Award supported by a Vanier Canada Graduate Scholarship(NSERC) 

主　　题：neural precursor ventricular zone pannexin ATP cytoskeleton proliferation phagoptosis 

摘      要：We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous studies on Pannexin 1 in neural precursors as well as the close rela- tionship between Pannexin 1 and purinergic receptors established by other groups. Moreover, we identify important gaps in our understanding of Pannexin 1 in neural precursor cell biology in terms of the under- lying molecular mechanisms and functional/behavioural outcomes.