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Cellular and Molecular Requirements for Polar PIN Targeting and Transcytosis in Plants

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Molecular Plant 2008年第6期1卷 1056-1066页

作者： Jurgen Kleine-Vehn tukasz tangowski Justyna Wisniewska Pankaj Dhonukshe Philip B Brewer Jiri Friml Department of Plant Systems Biology VIB and Department of Molecular Genetics Ghent University 9052 Gent Belgium zentrum fur Molekularbiologie der Pflanzen (ZMBP) Universitat Tubingen 72076 Tubingen Germany Present address: Institute of General and Molecular Biology Nicolas Copernicus University 87-100 Torun Poland Present address: Department of Biology Utrecht University 3508 TB Utrecht The Netherlands Present address: Centre for Integrative Legume Research University of Queensland Brisbane Australia

The polar, sub-cellular localization of PIN auxin efflux carriers determines the direction of intercellular auxin flow, thus defining the spatial aspect of auxin signalling. Dynamic, transcytosis-like relocalizations of PIN proteins occur in response to external and internal signals, integrating these signals into changes in auxin distribution. Here, we examine the cellular and molecular mechanisms of polar PIN delivery and transcytosis. The mechanisms of the ARF-GEF-dependent polar targeting and transcytosis are well conserved and show little variations among diverse Arabidopsis ecotypes consistent with their fundamental importance in regulating plant development. At the cellular level, we refine previous findings on the role of the actin cytoskeleton in apical and basal PIN targeting, and identify a previously unknown role for microtubules, specifically in basal targeting. PIN protein delivery to different sides of the cell is mediated by ARFdependent trafficking with a previously unknown complex level of distinct ARF-GEF vesicle trafficking regulators. Our data suggest that alternative recruitment of PIN proteins by these distinct pathways can account for cell type- and cargo-specific aspects of polar targeting, as well as for polarity changes in response to different signals. The resulting dynamic PIN positioning to different sides of cells defines a three-dimensional pattern of auxin fluxes within plant tissues.

关键词： cytoskeleton polarity protein targeting.

三正丁基膦稳定的铜(Ⅰ)β-二酮配合物的合成、表征以及作为前驱物用化学汽相沉积法生长铜膜(英文)

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无机化学学报 2004年第11期20卷 1257-1264页

作者：沈应中 Marion Leschke Stefan E. Schulz Ramona Ecke Thomas Gessner Heinrich Lang Technische Universitt Chemnitz Fakultat für Naturwissen-schaften Institut für Chemie Lehrstuhl Anorganische Chemie Straae der Nationen 62 09111 Chemnitz Germany Technische universitat Chemnitz Fakultat fü Elektrotechnik und Informationstechnik Zentrum fü Mikrotechnologien Reichenhainer Straae 70 09126 Chemnitz Germany

合成了一系列三正丁基膦辅助配体稳定的铜髣β鄄二酮配合物,对合成的配合物用元素分析、红外、核磁共振以及热重和差热等手段进行了表征。筛选出性能优良的配合物为前驱物用化学汽相沉积(CVD)的方法生长出金属铜膜,用SEM和EDX等手段对... 详细信息

合成了一系列三正丁基膦辅助配体稳定的铜髣β鄄二酮配合物,对合成的配合物用元素分析、红外、核磁共振以及热重和差热等手段进行了表征。筛选出性能优良的配合物为前驱物用化学汽相沉积(CVD)的方法生长出金属铜膜,用SEM和EDX等手段对生长的铜膜进行了表征。

关键词：三正丁基膦铜配合物 β-二酮合成前驱物化学汽相沉积法铜膜热分析扫描电镜 ×-射线能量散射

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老年人的视力损害:双重负荷?

德国医学 1999年第2期16卷 92-94页

作者： H.-W.Wahl V.Heyl F.Oswald U.Winkler 杨红 Deutsches zentrum für Alternsforschung an der Universitt heidelberg Bergheimer Str.20D-69115 HeidelbergGermany 同济医科大学附属同济医院

视力障碍和盲目多见于60岁以上的老年人。根据联邦统计局的调查结果,盲人约有70％,而其中90％是晚年盲目。一项来自福来明翰眼科研究中心(Framingham Eye Study)的资料显示,老年性白内障是52岁以上人群最常见的眼病,占15.6％,其次是老... 详细信息

视力障碍和盲目多见于60岁以上的老年人。根据联邦统计局的调查结果,盲人约有70％,而其中90％是晚年盲目。一项来自福来明翰眼科研究中心(Framingham Eye Study)的资料显示,老年性白内障是52岁以上人群最常见的眼病,占15.6％,其次是老年性黄斑变性,占8.8％,第3位是青光眼(3.3％),第4位是糖尿病视网膜病变(3.1％)。这4种眼病均与年龄有明显的相关性。

关键词：视力障碍老年人发病率双重负荷

Reducing loss of significance in the computation of Earth-based two-way Doppler observables for small body missions

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Research in Astronomy and Astrophysics 2021年第8期21卷 75-90页

作者： Wei-Tong Jin Fei Li Jian-Guo Yan Xuan Yang Mao Ye Wei-Feng Hao Thomas Paul Andert Jean-Pierre Barriot State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China State Key Laboratory of Satellite Navigation System and Equipment Technology Shijiazhuang 050200China Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan 430079China universitat der Bundeswehr München NeubibergBayern85579Germany University of French Polynesia BP 6570F-98702 Faa'aTahitiFrench Polynesia

Two-way Doppler measurement is a typical Earth-based radiometric technique for interplanetary spacecraft navigation and gravity science *** most widely used model for the computation of two-way Doppler observables is Moyer’s differenced-range Doppler(DRD) formula,which is based on a Schwarzschild approximation of the Solar-System ***,the computation of range difference in DRD formula is sensitive to round-off errors due to approximate numbers defined by the norm IEEE754 in all *** paper presented two updated models and their corresponding detailed instructions for the computation of the two-way Doppler observables so as to impair the effects of this type of numerical *** two models were validated by two case studies related to the Rosetta mission—asteroid Lutetia flyby and comet 67 P/Churyumov-Gerasimenko orbiting *** these two cases,the numerical noise from the updated models can be reduced by two orders-of-magnitude in the computed two-way Doppler *** results showed an accuracy from better than 6 × 10^(-3) mm s^(-1) at 1 s counting time interval to better than 3 × 10^(-5) mm s^(-1) at 60 s counting time interval.

关键词： methods:numerical space vehicles planets and satellites:general

伴缓慢性心律失常的睡眠呼吸暂停综合征的发病率和病死率

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德国医学 1995年第2期12卷 122-124页

作者： U.Koehler T.Wetzig J.H.Peter T.Ploch H.Schfer M.Stellwaag 蒋学俊 Medizinische Poliklinik Zentrum Innere Medizin der UniversitatBaldingerstraβeD-35043 MarburgGermany 同济医科大学附属同济医院

睡眠呼吸暂停综合征患者,心血管疾病发病率和病死率较高,可与心功能不全、高血压、肺动脉高压及缓慢性心律失常同时出现。睡眠呼吸暂停综合征合并冠心病者可出现心肌缺血。很多学者提出,伴缓慢性心律失常者病死率较高。本研究回顾性分... 详细信息

睡眠呼吸暂停综合征患者,心血管疾病发病率和病死率较高,可与心功能不全、高血压、肺动脉高压及缓慢性心律失常同时出现。睡眠呼吸暂停综合征合并冠心病者可出现心肌缺血。很多学者提出,伴缓慢性心律失常者病死率较高。本研究回顾性分析了伴和不伴夜间缓慢性心律失常的睡眠呼吸暂停综合征患者的发病率和病死率。

关键词：睡眠性呼吸暂停综合征心律失常发病率病死率

血管造影及经皮经腔血管成形术(PTA)的工作人员射线照射量

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放射学实践 1993年第2期8卷 83-87页

作者： L.Bogner H.Czempiel H.Gfirtner H.Gohlke H.-J.Lssl W.Maier M.Schtzl Th.Schmidt M.Wucherer 张在沛 Stadtisches Krankenhaus Schwabing Institut fur Medizinische Physik und StrahlenschutzKolner Platz 18000 Munchen 81 Klinikum Passau Medizinische Physik Bischof-Pilgrim-Str. 18390 Passau Elisabeth-Krankenhaus GmbH Radiologische Abteilung Medizinische Physik und Strahlenschutz Schulgasse 208440 Straubing Arztliche Stelle bei der Bayerischen Landesarztekammer Elsenheimerstr.378000 Munchen 21 Zentralklinikum Augsburg Radiologisches Zentrum 8900 Augsburg 1 Klinikum Groβhadern der Ludwig-Maximilians-universitat Munchen Klinik und Poliklinik fur Radiologie Marchioninistr. 158000 Munchen 70 Radiologlsches zentrum der Stadt Narnberg.Abteilung Fur Medizinische Physik.Flurstr.17.8500 Nurnberg 1 宜昌医学专科学校

从事诊断工作的人员职业性射线照射必须引起我们注意,以便采取一切必要的防护措施。若采取相应的预防措施,照射就不会超过临界剂量。

关键词：血管造影血管成形放射损伤医生

Wnt genes in colonic polyposis predisposition

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Genes & Diseases 2023年第3期10卷 753-757页

作者： Isabel Quintana Mariona Terradas Pilar Mur Iris B.A.Wte Paske Sophia Peters Isabel Spier Verena Steinke-Lange Claudia Maestro David Torrents Montserrat Puiggròs Romina Royo Raul Tonda Genís Parra Davide Piscia Sergi Beltrán Matilde Navarro Virginia Piñol Joan Brunet Noemi Gonzalez-Abuin Gemma Aiza Anna Sommer Yasmijn van Herwaarden Galuh Astuti Elke Holinski-Feder Nicoline Hoogerbrugge Richarda Mde Voer Stefan Aretz Gabriel Capellá Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Centro de Investigación Biomédica en Red de Cáncer(CIBERONC) Madrid 28029Spain Department of Human Genetics Radboud Institute for Molecular Life SciencesRadboud University Medical CenterGA Nijmegen 6525the Netherlands Member of SOLVE-RD ERN-GENTURIS Institute of Human Genetics Medical FacultyUniversity of BonnBonn 53127Germany National Center for Hereditary Tumor Syndromes University Hospital BonnBonn 53127Germany Medizinische Klinik Und Poliklinik IV Campus InnenstadtKlinikum Der Universität MünchenMunich 80336Germany MGZ-Medizinisch Genetisches zentrum Munich 80335Germany Life Sciences Department Barcelona Supercomputing Center(BSC)Barcelona 08034Spain ICREA Barcelona 08010Spain CNAG-CRG Centre for Genomic Regulation(CRG)Barcelona Institute of Science and TechnologyBarcelona 08028Spain universitat Pompeu Fabra(UPF) Barcelona 08002Spain Department of Genetics Microbiology and StatisticsSchool of BiologyUniversitat de Barcelona(UB)Barcelona 08028Spain Gastroenterology Unit Hospital Universitario de Girona Dr Josep TruetaGirona 17007Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Department of Gastroenterology and Hepatology Radboud University Medical CenterGA Nijmegen 6525the Netherlands Department of Human Genetics Radboud University Medical CenterGA Nijmegen 6525the Netherlands

Much of the genetic predisposition to polyposis,and particularly to serrated polyposis(SP),remains *** germline pathogenic variants in RNF43,a tumor suppressor that exerts negative feedback in the Wnt/β-catenin signaling pathway,have been causally linked to some SP cases(<2%),a disease associated with increased risk of colorectal cancer(CRC).^(1) Most known hereditary CRC and polyposis genes affect DNA repair,BMP/TGF-β,or Wnt signaling,being the latter associated with adenomatous and serrated polyposis phenotypes.2 Based on this observation,we evaluated the presence and role of germline variants in those pathways in unsolved polyposis patients.

关键词： polyposis suppressor colorectal

Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts

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Molecular Plant 2015年第8期8卷 1237-1252页

作者： Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt Department of Plant Physiology Institute of General Botany and Plant Physiology Friedrich-Schiller-University of Jena Domburger Strasse 159 07743 JenaGermany MIPS/IBI Helmholtz Zentrum MGnchen German Research Center for Environmental Health (GmbH) Ingolst~dter Landstrasse 1 85764 Neuherberg Germany Institute of Biology/Plant Physiology Humboldt-University Berlin Philippstrasse 13 Building 12 10115 Berlin Germany Institute of Biology Genetics Humboldt-University Berlin Chausseestrasse 117 10115 Berlin Germany present address: Institut fer Molekulare Biowissenschaften Pflanzliche Zellphysiologie Max-von-Laue-Strasse 9 Biozentrum Goethe-Universit~t Frankfurt 60438Frankfurt am Main Germany Present address: zentrum fur Molekulare Biologie an der universitat zu heidelberg (ZMBH) Im Neuenheimer Feld 282 69120 Heidelberg Germany present address: Universite Grenoble-Alpes F-38000 Grenoble France Present address: CNRS UMR5168 F-38054 Grenoble France present address: CEA iRTSV Laboratoire de Physiologie Cellulaire & Vgetale F-38054 Grenoble France Present address: INRA USC1359 F-38054 Grenoble France Present address: Plant Reproductive Biology Group Department of Physiology and Ceil-Biology Leibniz Institute of Rant Genetics and Crop Plant Research (IPK)OT Gatersleben Corrensstrasse 3 D-06466 Stadt Seeland Germany present address: KWS Saat AG Grimsehlstrasse 31 37555 Einbeck Germany present address: Dartmouth College Department of Biological Sciences Ufe Sciences Center 78 College Street Hanover NH 03755 USA

Natural illumination conditions are highly variable and because of their sessile life style, plants are forced to acclimate to them at the cellular and molecular level. Changes in light intensity or quality induce changes in the reduction/oxidation （redox） state of the photosynthetic electron chain that acts as a trigger for compen- satory acclimation responses comprising functional and structural adjustments of photosynthesis and metabolism. Such responses include redox-controlled changes in plant gene expression in the nucleus and organelles. Here we describe a strategy for the identification of early redox-regulated genes （ERGs） in the nucleus of the model organism Arabidopsis thaliana that respond significantly 30 or 60 min after the generation of a reduction signal in the photosynthetic electron transport chain. By comparing the response of wild-type plants with that of the acclimation mutant stn7, we could specifically identify ERGs. The results reveal a significant impact of chloroplast redox signals on distinct nuclear gene groups including genes for the mitochondrial electron transport chain, tetrapyrrole biosynthesis, carbohydrate metabolism, and signaling lipid synthesis. These expression profiles are clearly different from those observed in response to the reduction of photosynthetic electron transport by high light treatments. Thus, the ERGs identified are unique to redox imbalances in photosynthetic electron transport and were then used for analyzing potential redox-responsive cis-elements, trans-factors, and chromosomal regulatory hot spots. The data identify a novel redox-responsive element and indicate extensive redox control at transcriptional and chromosomal levels that point to an unprecedented impact of redox signals on epigenetic processes.

关键词： plastidial redox signaling,early redox-regulated gene Arabidopsis thaliana Molecular Plant

Meta-Analysis of Retrograde Signaling in Arabidopsis thaliana Reveals a Core Module of Genes Embedded in Complex Cellular Signaling Networks

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Molecular Plant 2014年第7期7卷 1167-1190页

作者： Christine GlaiBer Georg Haberer Iris Finkemeier Thomas Pfannschmidt Tatjana Kleine Dario Leister KarI-Josef Dietz Rainer Erich Haiusler Bernhard Grimm Klaus Franz Xaver Mayer Helmholtz zentrum Munchen German Research Center for Environmental Health Institute of Bioinformatics and Systems Biology(IBIS) Ingolstadter Landstr. 1 D-85764 Neuherberg Germany Biozentrum der LMU Munchen Department of Biologie I-Botanik Groβhaderner Str. 2-4 D-82152 Planegg-Martinsried Germany Friedrich-Schiller-universitat Jena Institut fur AIIgemeine Botanik und Pflanzenphysiologie Dornburger Str. 159 D-07743 JenaGermany Laboratoire de Physiologie Cellulaire Vegetale (LPCV) CEA/CNRS/UJF iRTSV CEA Grenoble 17 rue des Martyrs 38054 Grenoble cedex 9France Biochemistry and Physiology of Plants Faculty of Biology Bielefeld University Universit~tsstrai3e 25 D-33615 Bielefeld Germany University of Cologne Botanical Institute Cologne Biocenter Zu1picher Str. 47B D-50674 Cologne Germany Humboldt-universitat zu Berlin Institut fur Biologie AG Pflanzenphysiologie Philippstrasse 13 D-10115 Berlin Germany

Plastid-to-nucleus signaling is essential for the coordination and adjustment of cellular metabolism in response to environmental and developmental cues of plant cells. A variety of operational retrograde signaling path- ways have been described that are thought to be triggered by reactive oxygen species, photosynthesis redox imbalance, tetrapyrrole intermediates, and other metabolic traits. Here we report a meta-analysis based on transcriptome and pro- tein interaction data. Comparing the output of these pathways reveals the commonalities and peculiarities stimulated by six different sources impinging on operational retrograde signaling. Our study provides novel insights into the interplay of these pathways, supporting the existence of an as-yet unknown core response module of genes being regulated under all conditions tested. Our analysis further highlights affiliated regulatory cis-elements and classifies abscisic acid and auxin-based signaling as secondary components involved in the response cascades following a plastidial signal. Our study provides a global analysis of structure and interfaces of different pathways involved in plastid-to-nucleus signaling and a new view on this complex cellular communication network.

关键词： retrograde signaling meta-analysis abscisic acid auxin.