Meta-Analysis of Retrograde Signaling in Arabidopsis thaliana Reveals a Core Module of Genes Embedded in Complex Cellular Signaling Networks

作     者：Christine GlaiBer Georg Haberer Iris Finkemeier Thomas Pfannschmidt Tatjana Kleine Dario Leister KarI-Josef Dietz Rainer Erich Haiusler Bernhard Grimm Klaus Franz Xaver Mayer 

作者机构：Helmholtz Zentrum Munchen German Research Center for Environmental Health Institute of Bioinformatics and Systems Biology(IBIS) Ingolstadter Landstr. 1 D-85764 Neuherberg Germany Biozentrum der LMU Munchen Department of Biologie I-Botanik Groβhaderner Str. 2-4 D-82152 Planegg-Martinsried Germany Friedrich-Schiller-Universitat Jena Institut fur AIIgemeine Botanik und Pflanzenphysiologie Dornburger Str. 159 D-07743 JenaGermany Laboratoire de Physiologie Cellulaire Vegetale (LPCV) CEA/CNRS/UJF iRTSV CEA Grenoble 17 rue des Martyrs 38054 Grenoble cedex 9France Biochemistry and Physiology of Plants Faculty of Biology Bielefeld University Universit~tsstrai3e 25 D-33615 Bielefeld Germany University of Cologne Botanical Institute Cologne Biocenter Zu1picher Str. 47B D-50674 Cologne Germany Humboldt-Universitat zu Berlin Institut fur Biologie AG Pflanzenphysiologie Philippstrasse 13 D-10115 Berlin Germany 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2014年第7卷第7期

页      面：1167-1190页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 081302[工学-建筑设计及其理论] 071009[理学-细胞生物学] 0813[工学-建筑学] 0901[农学-作物学] 0902[农学-园艺学] 

基　　金：support by the Deutsche Forschungsgemeinschaft 

主　　题：retrograde signaling meta-analysis abscisic acid auxin. 

摘      要：Plastid-to-nucleus signaling is essential for the coordination and adjustment of cellular metabolism in response to environmental and developmental cues of plant cells. A variety of operational retrograde signaling path- ways have been described that are thought to be triggered by reactive oxygen species, photosynthesis redox imbalance, tetrapyrrole intermediates, and other metabolic traits. Here we report a meta-analysis based on transcriptome and pro- tein interaction data. Comparing the output of these pathways reveals the commonalities and peculiarities stimulated by six different sources impinging on operational retrograde signaling. Our study provides novel insights into the interplay of these pathways, supporting the existence of an as-yet unknown core response module of genes being regulated under all conditions tested. Our analysis further highlights affiliated regulatory cis-elements and classifies abscisic acid and auxin-based signaling as secondary components involved in the response cascades following a plastidial signal. Our study provides a global analysis of structure and interfaces of different pathways involved in plastid-to-nucleus signaling and a new view on this complex cellular communication network.