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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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Clinical Observation in 46 Cases of Angina Pectoris Treated by the Catgut-embedding Therapy

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Journal of Traditional Chinese Medicine 2003年第3期23卷 199-200页

作者：李志广陈正秋 xinxiang tcm hospital Xinxiang 453003Henan Province

With the catgut-embedding therapy, the author treated 46 cases of angina pectoris from October 1997 to February 2002, and achieved good therapeutic results. This is reported as follows.

关键词： Acupuncture Points Catgut Prostheses and Implants Adult Aged Aged, 80 and over Angina Pectoris Drugs, Chinese Herbal Female Humans Male Middle Aged

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Cyanuric chloride-catalyzed synthesis of 10-aryl-6,8-dimethyl-6,10-dihydro-5-oxa-6,8-diazaanthra[2,3-d][1,3]dioxole-7,9-diones

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Chinese Chemical Letters 2011年第7期22卷 811-814页

作者： Wei Lin Li Qiu Yan Luo Fu Lin Yan School of Pharmacy Xinxiang Medical University Xinxiang 453003 China Department of Gynecological and Obstetric Third Affiliated Hospital to Xinxiang Medical University Xinxiang 453003 China

An environmentally friendly procedure for the preparation of 10-aryl-6,8-dimethyl-6,10-dihydro-5-oxa-6,8-diazaanthra[2,3- d] [ 1,3]dioxole-7,9-diones under thermal solvent-free conditions in the presence of cyanurie c... 详细信息

关键词： Bcnzodioxoles 3,4-Methylenedioxyphenol 1,3-Dimethylbarbituric acid Cyanuric chloride Solvent-free

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Aminooxyacetic acid improves learning and memory in a rat model of chronic alcoholism

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Neural Regeneration Research 2018年第9期13卷 1568-1574页

作者： Ai-Lin Du Hao-Zhi Qin Hong-Bo Jiang Peng-Yan Fu Ke Lou Yu-Ming Xu Department of Neurology First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province China Department of Physiology and Neurobiology Xinxiang Medical University Henan Provincial Key Laboratory of Brain Research Second Affiliated Hospital of Xinxiang Medical University Xinxiang Henan Province China Third Affiliated hospital of xinxiang Medical University Xinxiang Henan Province China

Chronic alcoholism seriously damages the central nervous system and leads to impaired learning and *** damage in chronic alcoholism is strongly associated with elevated levels of hydrogen sulfide（H2S） and calcium ion *** acid is a cystathionine-β-synthase activity inhibitor that can reduce H2S formation in the *** study sought to observe the effect of aminooxyacetic acid on learning and memory in a chronic alcoholism rat *** were randomly divided into three *** in the control group were given pure water for 28 *** in the model group were given 6% alcohol for 28 days to establish an alcoholism rat *** in the aminooxyacetic acid remedy group were also given 6% alcohol for 28 days and were also intraperitoneally injected daily with aminooxyacetic acid（5 mg/kg） from day 15 to day *** and memory was tested using the Morris water maze *** ultrastructure of mitochondria in the hippocampus was observed by electron microscopy.H2S levels in the hippocampus were measured indirectly by spectrophotometry,and ATPase activity was measured using a commercial *** expression of myelin basic protein was determined by immunohistochemistry and western *** with the control group,latency and swimming distance were prolonged in the navigation test on days 2,3,and 4 in the model *** the spatial probe test on day 5,the number of platform crosses was reduced in the model *** cracks,swelling or deformation of mitochondria appeared in the hippocampus,the hippocampal H2S level was increased,the mitochondrial ATPase activity was decreased,and the expression of myelin basic protein in the hippocampus was down-regulated in the model group compared with the control *** the above indexes were ameliorated in the aminooxyacetic acid remedy group compared with the model *** findings indicate that aminooxyacetic acid can improve learning and memory in a chronic alcoholism rat model,w

关键词： nerve regeneration aminooxyacetic acid chronic alcoholism rat model hydrogen sulfide Ca2+ overload brain injury learning andmemory abilities Morris water maze myelin basic protein mitochondria ATP enzyme activity neural regeneration

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Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1

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Journal of Genetics and Genomics 2023年第3期50卷 192-203页

作者： Zheying Zhang Wenyan Fan Qingzu Gao Yifei Han Jingyu Ma Wuji Gao Yuhan Hu Huifang Zhu Rui Yang Haijun Wang Baoshun Du Zuoyang Zhang Jiateng Zhong Department of Pathology School of Basic Medical SciencesXinxiang Medical UniversityXinxiangHenan 453003China Department of Microscopic Morphology Laboratory School of Basic Medical SciencesXinxiang Medical UniversityXinxiangHenan 453003China Department of Pathology The First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan 453003China School of Life Science and Technology Xinxiang Medical UniversityXinxiangHenan 453003China Second Department of Neurosurgery Xinxiang Central HospitalXinxiangHenan 453003China Department of Pathology Anhui Medical UniversityHefeiAnhui 230032China

Many circular RNAs(circRNAs)are reported to be abnormally expressed during the progression of various tumors,and these circRNAs can be used as anti-tumor ***,it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer(CRC).Here,we report that hsa_Circ_0000826(Circ_0000826),a circ RNA with significantly reduced expression level in CRC tissues,is associated with a poor prognosis in *** silencing of Circ_0000826 promotes the proliferation of CRC ***,the overexpression of Circ_0000826 restricted CRC cell proliferation both in vitro and in ***,Circ_0000826 could target AU-rich element RNA-binding protein 1(AUF1).AUF1,known as heterogeneous nuclear ribonucleoprotein D(hnRNP D),could bind to the c-MYC 3’-UTR and promote c-MYC *** Circ_0000826 binds to AUF1,it competitively inhibits the binding of AUF1 to the c-MYC 3’-UTR,which inhibits the c-MYC expression and cell *** results provide novel insights into the functional mechanism of Circ_0000826 action in CRC progression and indicate its potential use as a therapeutic target in CRC.

关键词： Colorectal cancer Hsa_Circ_0000826 AUF1 Proliferation CircRNA

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Expression and antioxidation of Nrf2/ARE pathway in traumatic brain injury

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Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 305-310页

作者： Zhen-Guo Cheng Guo-Dong Zhang Peng-Qiang Shi Bao-Shun Du Second Department of Neurosurgery Xinxiang Central Hospital

Objective:To explore the expression of Nrf2/ARE pathway in hindbrain tissue after the traumatic brain injury（TBI） and its anli-oxidative stress effect in the secondary nerve ***: The mice with Nrf2 gene knockout were used for the establishment of brain injury *** experimental animals were divided into four groups:(Nrf2+/+) sham-operation group,(Nrf2+/+) brain injury group,（Nrf2T） sham-operation group and(Nrf2-/-) brain injury *** specimen 24 h after cerebral trauma was *** RT-PCR method was adopted to detect the expression of Nrf2 mRNA in brain;Western blotting method was adopted to detect the levels of Nrf2,HO-1 and NQO1 proteins in brain;EUSA method was adopted to detect the oxidative stress indicators: protein carbonyls,4-hydroxy-2-nonenal（4-HNE） and 8-hydroxy-2’-deoxyguanosine（8-OHdG）. ResuHs:The Nrf2 mRNA and protein of Nrf2-/- mice were not expressed,and the diflerence of the relative amount of Nrf2 mRNA between Nrf2+/+ TBI group and Nrf2+/+ sham-operation group was not statistically significant（P>0.05）;the level of Nrf2 protein in Nrf2+/+ TBI group increased significantly compared with the Nrf2+/+ sham-operation group（P-/- mice decreased obviously compared with the Nrf2+/+ mice（P+/+ mice increased obviously compared with the corresponding sham-operation group（P-/- mice in TBI group had no obvious change compared with the corresponding sham-operation group（P>0.05）;there was only a little amount of expression of protein carbonyls,4-HNE and 8-OHdG proteins in brain tissues in the Nrf2-/+ and Nrf2-/- shamoperation groups,and the difference was not statistically signif

关键词： Traumatic brain injury Nrf2/ARE pathway Gene expression Anti-oxidative stress

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Analysis of influencing factors of anxiety and depression in patients with periodontitis

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World Journal of Psychiatry 2024年第1期14卷 141-147页

作者： Yao Kong Department of Stomatology Xinxiang Central HospitalXinxiang 453000Henan ProvinceChina

BACKGROUND Periodontitis is a chronic oral disease caused by pathogenic microorganisms that corrode tooth tissue,form periodontal pockets,absorb alveolar bone,and finally lead to tooth *** treatment,patients are prone to anxiety,tension,and other negative emotions,which affect their ability to face the disease and may also lead to aggravation of the original condition and affect oral ***,it is important to improve the negative psychology of patients with periodontitis to clarify the factors that may lead to negative psychological *** To investigate the risk factors that may lead to anxiety and depression in patients with *** One hundred patients with periodontitis were selected between March 2022 and March 2023 at our *** patients were assessed with the Zung Self-rating Depression Scale(SDS)(≥53 points indicate a depressive state)and Zung Selfrating Anxiety Scale(SAS)(≥50 points indicates an anxious state).In this study,patients who experienced anxiety or depression were included in the occurrence group and those without anxiety or depression were included in the nonoccurrence *** baseline data of the two groups were compared to explore the risk factors for anxiety and depression in patients with *** A total of 100 patients with periodontitis were included in this *** to the SDS,38 patients(38.00%)developed depression,with an average SDS score of(68.52±5.85)*** to the SAS,40 patients(40.00%)developed anxiety,and the average SAS score was(72.15±4.15)*** this study,56 patients with anxiety or depression were *** with the nonoccurrence group,the occurrence group had higher ages(≥60 years),lower level of hope(low level),educational level(high school or below),disease perception(poor),and sleep disorder(yes).The negative coping dimension scores of the simplified coping style questionnaire(SCSQ)and Dental Fear Scale(DFS)in the occurrence group were

关键词： Periodontitis Anxiety Depression Mental state Influencing factor

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Small particle drug-eluting beads-transarterial chemoembolization combined with targeted therapy in the clinical treatment of unresectable liver cancer

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4157-4165页

作者： Jing-Song Qi Peng Zhao Xiao-Bo Zhao Yong-Li Zhao Ying-Chang Guo Department of Interventional The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina

BACKGROUND Liver cancer is a highly malignant tumor with significant clinical *** alone often yields suboptimal outcomes in both the short and long term,characterized by high rates of local recurrence and distant metastasis,leading to a poor long-term *** To evaluate the clinical efficacy of small particle drug-eluting beads-transarterial chemoembolization(DEB-TACE)combined with targeted therapy for the treatment of unresectable liver *** We analyzed clinical data from 74 patients with unresectable liver cancer admitted between January 2019 and December *** on the different treatment regimens administered,patients were divided into the control(36 patients receiving sorafenib alone)and joint(38 patients receiving small particle DEB-TACE combined with sorafenib)*** compared liver function indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),albumin(ALB)]and serum tumor markers[alpha fetoprotein(AFP)]before and after treatment in both ***-term efficacy measures[complete response(CR),partial response,progression disease,stable disease,objective response rate(ORR),and disease control rate(DCR)]were assessed ***-term follow-up evaluated median overall survival(OS),progression-free survival(PFS),and adverse reaction rates between the two *** One month post-treatment,the joint group demonstrated significantly higher rates of CR,ORR,and DCR compared to the control group(P<0.05).Three days after treatment,the joint group showed elevated levels of ALT,AST,and TBIL but reduced levels of ALB and AFP compared to the control group(P<0.05).The median OS was 18 months for the control group and 25 months for the joint group,while the median PFS was 15 months for the control group and 22 months for the joint group,with significant differences observed(log-rank:χ2=7.824,6.861,respectively;P=0.005,0.009,respectively).The incidence of adverse reactions was not s

关键词： Small particle Drug-eluting beads-transarterial chemoembolization Sorafenib Treatment Unresectable liver cancer

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Aspirin suppresses hepatocellular carcinoma progression by inhibiting platelet activity

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2742-2756页

作者： Li-Jun Zhao Zhi-Yin Wang Wei-Ting Liu Li-Li Yu Hao-Nan Qi Jie Ren Chen-Guang Zhang Hematology Laboratory The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy School of Medical TechnologyXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiang 453003Henan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common malignant liver disease in the ***(PLTs)are known to play a key role in the maintenance of liver homeostasis and the pathophysiological processes of a variety of liver *** is the most classic antiplatelet ***,the molecular mechanism of platelet action and whether aspirin can affect HCC progression by inhibiting platelet activity need further *** To explore the impact of the antiplatelet effect of aspirin on the development of *** Platelet-rich plasma,platelet plasma,pure platelet,and platelet lysate were prepared,and a coculture model of PLTs and HCC cells was ***-8 analysis,apoptosis analysis,Transwell analysis,and real-time polymerase chain reaction(RT-PCR)were used to analyze the effects of PLTs on the growth,metastasis,and inflammatory microenvironment of ***-PCR and Western blot were used to detect the effects of platelet activation on tumor-related signaling *** was used to block the activation and aggregation of PLTs both in vitro and in vivo,and the effect of PLTs on the progression of HCC RESULTS PLTs significantly promoted the growth,invasion,epithelial-mesenchymal transition,and formation of an inflammatory microenvironment in HCC *** PLTs promoted HCC progression by activating the mitogenactivated protein kinase/protein kinase B/signal transducer and activator of transcription three(MAPK/AKT/STAT3)signaling ***,aspirin inhibited HCC progression in vitro and in vivo by inhibiting platelet *** PLTs play an important role in the pathogenesis of HCC,and aspirin can affect HCC progression by inhibiting platelet *** results suggest that antiplatelet therapy has promising application prospects in the treatment and combined treatment of HCC.

关键词： Platelets Antiplatelet therapy Hepatocellular carcinoma Aspirin Antitumor

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mi R-382 functions as a tumor suppressor against esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2017年第23期23卷 4243-4251页

作者： Jie Feng Bo Qi Ling Guo Ling-Yun Chen Xiu-Feng Wei Yu-Zhen Liu Bao-Sheng Zhao Department of Thoracic Surgery The First Affiliated Hospital of Xinxiang Medical University Department of Operating Room The First Affiliated Hospital of Xinxiang Medical University

AIM To explore the effect of miR-382 on esophageal squamous cell carcinoma (ESCC) in vitro and its possible molecular mechanism. METHODS Eca 109 cells derived from human ESCC and Het-1A cells derived from human normal esophageal epithelium were used. Lentivirus-mediated miR-382 was overexpressed in Eca109 cells. The effect of miR-382 on cell proliferation was evaluated by MTT and colony formation assay. For cell cycle analysis, cells were fixed and stained for 30 min with propidium iodide (PI) staining buffer containing 10 mg/mL PI and 100 mg/mL RNase A, and analyzed by BD FACSCalibur (TM) flow cytometer. For cell apoptosis assay, cells were stained with an Annexin V-FITC/PI Apoptosis Detection Kit according to the manufacturer's instructions and analyzed by a dual-laser flow cytometer. Cell invasion and migration abilities were determined through use of transwell chambers, non-coated or pre-coated with matrigel. Levels of proteins related to cell growth and migration were examined by western blotting. RESULTS Endogenous miR-382 was down-regulated in Eca109 cells compared with Het-1A. Introduction of miR-382 not only significantly inhibited proliferation and colony formation, but also arrested cell cycle at the G2/M phase, as well as promoted apoptosis and autophagy in Eca109 cells. Migration, invasion and epithelial-mesenchymal transition of Eca109 cells were suppressed by overexpressing miR-382. Western blotting results showed that miR-382 inhibited the phosphorylation of mTOR and 4E-BP1. CONCLUSION miR-382 functions as a tumor suppressor against ESCC development and metastasis, and could be considered as a potential drug source for the treatment of ESCC patients.

关键词： miR-382 Esophageal squamous cell carcinoma Tumor suppressor Proliferation Migration Invasion

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