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Synthesis of mono-substituted derivatives of 6-aminoquinoline

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Chinese Chemical Letters 2011年第3期22卷 253-255页

作者： Tian Lan Xian Xia Yuan Jiang Hong Yu Chao Jia Yu Shi Wang Hui Juan Zhang Zi Feng Ma Wei Dong Ye School of Chemistry and Chemical Engineering Shanghai Jiaotong University Shanghai 200240 China School of Pharmacy Shanghai Jiaotong University Shanghai 200240 China xinchang Pharmaceutical factory Zhejiang Pharmaceutics Co. Ltd. Xinchang 312500 China

Several 6-aminoquinoline derivatives,which could be used in drug design,have been *** reaction conditions were comparatively studied,and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller ***... 详细信息

关键词： 6-Aminoquinoline 6-Nitroquinoline Skraup reaction Oxidant

Measurement and Influence Factors of the Flowability of Microcapsules with High-content β-Carotene

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Chinese Journal of Chemical Engineering 2007年第4期15卷 579-585页

作者：许新德姚善泾韩宁邵斌 Department of Chemical and Biochemical Engineering Zhejiang University Hangzhou 310027 China xinchang Pharma. factory Zhejiang Medical Co. Ltd. Xinchang 312500 China

The flowability of five kinds of microencapsulation powders,with differentβ-carotene contents and by two alternative particle-forming technologies ***-drying and starch-catching beadlet technology,was meas- *** actual flow properties of the five powders were compared based on bin-flow test,and three flow indexes (Hausner ratio,repose angle and flow index)were *** was found that the repose angle is the most suitable index to reflect the flowability of these powders for the particle properties would not be altered due to compaction or tapping during the measuring *** size and particle size distribution play most important roles in the flowability of these granular materials,which was also influenced by other factors like shape,surface texture,sur- face roughness,*** with wall material of gelatin and a layer of modified starch absorbed on the sur- face showed excellent flowabilities and good mechanical properties,and they are favorable for tabletting to supply β-carotene.

关键词： β-carotene microcapsule powders flowability Hausner ratio repose angle

Meso-Zeaxanthin:One of Important Carotenoids for Human Health

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Journal of Northeast Agricultural University(English Edition) 2010年第3期17卷 76-81页

作者： XU Xinde JIANG Lianzhou ZHANG Lihua SHAO Bin Zhejiang Medicine Co. Ltd. Xinchang Pharmaceutical Factory Xinchang 312500 Zhejiang China College of Food Sciences Northeast Agricultural University Harbin 150030 China

As one of optical isomers of zeaxanthin, meso-zeaxanthin is an important ingredient of macular pigment. Compared with lutein and zeaxanthin, meso-zeaxanthin may display strong functions as antioxidant and filtering short-wavelength, for example, the blue light. Comparisons among lutein, zeaxanthin and meso-zeaxanthin as well as functions and distributions together with the source of meso-zeaxanthin were discussed. The application as a supplement of diet and issues should be studied in the future for mesozeaxanthin were also analyzed.

关键词： meso-zeaxanthin function distribution source application

A new isobenzofuranone derivative from a marine Streptomyces sp.

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Chinese Chemical Letters 2012年第8期23卷 941-944页

作者： Ze Ping Xie Hong Yu Zhang FU Chao Li Bing Liu Sheng Xiang Yang Hong Peng Wang Yang Pu Yi Chen Song Qin Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao Chemical Biological Research Institute College of ScienceNorthwest A&F UniversityYangling 712100 Graduate University of Chinese Academy of Sciences Beijing 100049China 266071China China Department of Organic and Biomolecular Chemistry University of GottingenGottingen D-37077Germany Zhejiang Medicine Co. Ltd.Xinchang Pharmaceutical FactoryXinchang 312500China

One new isobenzofuranone derivative, 1,4-dimethoxy-3-（3R＊-hydroxy-3R＊-methyl-1-tetralone）-1 （3H）-isobenzofuran （1）, was isolated from the broth of marine Streptomyces sp. M268. The structure was elucidated by spectroscopy characteristics as well as comparison with the literature. Compound 1 exhibited cytotoxicities against human cancer cell, HL-60, A549, and BEL-7402.

关键词： Isobenzofuranone Marine Streptomyces Bioactivity

Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives

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International Journal of Organic Chemistry 2013年第1期3卷 41-46页

作者： Dongping Shao Yanbing Yang Fei Xue Xianjin Luo Reyila Wubulikasimu Yuhuan Li Rongmei Gao Weidong Ye Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai China Zhejiang Medicine Co. Ltd. Xinchang Pharmaceutical Factory Xinchang China

A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.

关键词： 1 2 4-Triazole Anti-Enterovirus Coxsackie B Viruses