Knoevenagel Condensation Catalyzed by DBU Brnsted Ionic Liquid without Solvent

作     者：YING An-guo LIU Luo WU Guo-feng CHEN Xin-zhi YE Wei-dong CHEN Jian-hui ZHANG Kai-yuan 

作者机构：Department of Chemical and BiOlogical Engineering Zhejiang University Hangzhou 310027 P. R. China Xinchang Pharmaceuticals Factory Zhejiang Medicine Co. Ltd. Xinchang 312500 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2009年第25卷第6期

页      面：876-881页

核心收录：

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：Supported by the National Natural Science Foundation of China(No.20776127) the National Key Technology Research and Development Program of China(No.2007BAI34B07) 

主　　题：Knoevenagel condensation [DBU][Lac] Ionic liquid Aromatic aldehydes Active methylene compound 

摘      要：A protocol for the Knoevenagel condensation of aromatic aldehydes with methylene compounds catalyzed by task specifed ionic liquid 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium lactate under solvent-free conditions has been developed. The reactions proceed at ambient temperature and the work-up procedures are very simple. Good to excellent yields could be obtained. The ionic liuid could be simply prepared and recycled efficiently.