检索结果-南通市图书馆

Studies on LH modulated 8 kDa peptide involved regulation of testosterone production in rat Leydig cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 1999年第4期1卷 191-194页

作者： P.Ramaraj A.Jagannadha Rao Department of diabetes Endocrinology & Metabolism The University of Hope National Medical Centre 15000 East Duarte Road Duarte CA 91007 USADepartment of Biochemistry & Department of Molecular Reproduction Development & Genetics Indian Institute of Science Bangalore-560 0112 India

Aim: To demonstrate the role of the 8 kDa peptide in regulation of testosterone production by mt Leydig cells. Meth-ods: A peptide similar to 8 kDa peptide purified from immature rat Leydig cells was isolated and purified from rat lungcytosol. Immunological and structural similarity between the peptides purified from lung and Leydig cells was estab-lished by Western blot and tryptic map comparison respectively. Results: Addition of the 8 kDa peptide 10, 50, 100;and 150 ug decreased the production of testosterone in Leydig cells dose-dependently. But the addition of the peptide150 ug along with hCG had no effect on hCG-stimulated increase in testosterone production. Conclusion: In vitro ad-dition of the peptide purified from lung cytosol to adult rat Leydig cells resulted in a concentration-dependent decrease inbasal testosterone production although it had no effect on hCG-stimulated testosterone production. (Asian J Androl1999 Dec; 1: 191-194)

关键词： Leydig cells testosterone regulation differentiation steroidogenesis peptides LH

The development and application of Laboratory Animal Science in China

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2018年第4期1卷 247-249页

作者： Patri Vergara Grant Morahan International Council for Laboratory Animal Science (ICLAS) centre for diabetes Research Harry Perkins Institute of Medical Research

The 14th Scientific Congress of the Chinese Association for Laboratory Animal Science was held on October 11‐12,2018 in Qingdao,*** this congress,an international forum on the development of Laboratory Animal Sciences(LAS)worldwide was held in which participants learnt about the development of new LAS resources and technologies,as well as the progress of LAS in *** main points that were discussed are as *** nearly a century of development,there are more than 200 species of experimental animals,and more than 20 000 inbred lines,outbred lines,genetic engineered animals,animal models of diseases,and other resources all over the world,which provide abundant experimental animal resources for scientific *** resources are widely used in life science research.

关键词： Laboratory Animal Science Chinese Association Laboratory Animal Sciences(LAS)

Inflammatory bowel disease and diabetes:Is there a link between them?

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of diabetes 2022年第2期13卷 126-128页

作者： Miao-Miao Sang Zi-Lin Sun Tong-Zhi Wu Department of Endocrinology Zhongda HospitalInstitute of DiabetesSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Adelaide Medical School and centre of Research Excellence in Translating Nutritional Science to Good Health The University of AdelaideAdelaideSA 5000Australia

Patients with inflammatory bowel disease(IBD)are reported to have an increased risk of *** therapies may also modulate blood glucose *** observations are indicative of mechanistic connection(s)between IBD and diabetes.

关键词： Inflammatory bowel disease Abnormal glucose metabolism

Pancreatic exocrine insufficiency, diabetes mellitus and serum nutritional markers after acute pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第48期20卷 18432-18438页

作者： Miroslav Vujasinovic Bojan Tepes Jana Makuc Sasa Rudolf Jelka Zaletel Tjasa Vidmar Maja Seruga Bostjan Birsa Miroslav Vujasinovic Jana Makuc Tjasa Vidmar Department of Internal Medicine Slovenj Gradec General Hospital Slovenj Gradec 2380 Slovenia Abakus Medico Diagnostic centre Rogaska Slatina 3250 Slovenia Department of Radiology University Medical Centre Maribor Maribor 2000 Slovenia Department of Endocrinology Diabetes and Metabolic Diseases University Medical Centre Ljubljana Ljubljana 1000 Slovenia Department of Internal Medicine Murska Sobota General Hospital Murska Sobota 9001 Slovenia Department of Internal Medicine Celje General Hospital Celje 3000 Slovenia

AIM: To investigate impairment and clinical significance of exocrine and endocrine pancreatic function in patients after acute pancreatitis (AP).

关键词： Acute pancreatitis diabetes mellitus Pancreatic exocrine insufficiency Serum nutritional markers

Development of innovative tools for investigation of nutrient-gut interaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第25期26卷 3562-3576页

作者： Wei-Kun Huang Cong Xie Richard L Young Jiang-Bo Zhao Heike Ebendorff-Heidepriem Karen L Jones Christopher K Rayner Tong-Zhi Wu Adelaide Medical School Centre of Research Excellence in Translating Nutritional Science to Good Healththe University of AdelaideAdelaideSA 5005Australia Institute for Photonics and Advanced Sensing School of Physical SciencesUniversity of AdelaideAdelaideSA 5005Australia The ARC centre of Excellence for Nanoscale BioPhotonics AdelaideSA 5005Australia diabetes Nutrition and Gut HealthLifelong HealthSouth Australia Health and Medical Research InstituteAdelaideSA 5005Australia Department of Gastroenterology and Hepatology Royal Adelaide HospitalAdelaideSA 5000Australia Department of Endocrinology Zhongda HospitalInstitute of DiabetesSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

The gastrointestinal tract is the key interface between the ingesta and the human *** is wide recognition that the gastrointestinal response to nutrients or bioactive compounds,particularly the secretion of numerous hormones,is critical to the regulation of appetite,body weight and blood *** concept has led to an increasing focus on“gut-based”strategies for the management of metabolic disorders,including type 2 diabetes and *** the underlying mechanisms and downstream effects of nutrient-gut interactions is fundamental to effective translation of this knowledge to clinical *** this end,an array of research tools and platforms have been developed to better understand the mechanisms of gut hormone secretion from enteroendocrine *** review discusses the evolution of in vitro and in vivo models and the integration of innovative techniques that will ultimately enable the development of novel therapies for metabolic diseases.

关键词： Nutrient-gut interaction Metabolic disorders Incretin hormones Enteroendocrine cells Enteroids Intestinal intubation Intestine-on-a-chip

Prospective,multicentre study of screening,investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2023年第3期8卷 207-216,I0028-I0059页

作者： James J M Loan Steven Tominey Kirun Baweja Julie Woodfield Thomas J G Chambers Mark Haley Simran S Kundu H Y Josephine Tang Anthony N Wiggins Michael T C Poon Paul M Brennan Translational Neurosurgery The University of Edinburgh Centre for Clinical Brain SciencesEdinburghUK Neurosurgery NHS LothianEdinburghUK Neurosurgery Institute of Neurological SciencesGlasgowUK Department of Medicine School of MedicineDentisty and NuringUniversity of GlasgowGlasgowUK Internal Medicine Queen's UniversityKingstonOntarioCanada centre for Discovery Brain Sciences University of EdinburghEdinburghUK Edinburgh centre for diabetes and Endocrinology NHS LothianEdinburghUK Radiology University Hospitals Plymouth NHS TrustPlymouthUK Department of Medicine Cork University HospitalUniversity College CorkCorkIreland

Background Hyponatraemia often occurs after subarachnoid haemorrhage(SAH).However,its clinical significance and optimal management are *** audited the screening,investigation and management of hyponatraemia after *** We prospectively identified consecutive patients with spontaneous SAH admitted to neurosurgical units in the United Kingdom or *** reviewed medical records daily from admission to discharge,21 days or death and extracted all measurements of serum sodium to identify hyponatraemia(10 *** of hyponatraemia with outcome were assessed using logistic regression with adjustment for predictors of outcome after SAH and admission *** assessed hyponatraemia-free survival using multivariable Cox *** 175/407(43%)patients admitted to 24 neurosurgical units developed hyponatraemia.5976 serum sodium measurements were *** osmolality,urine osmolality and urine sodium were measured in 30/166(18%)hyponatraemic patients with complete *** most frequently target daily fluid intake was>3 L and this did not differ during hyponatraemic or non-hyponatraemic episodes.26%(n/N=42/164)patients with hyponatraemia received sodium supplementation.133(35%)patients were dead or dependent within the study period and 240(68%)patients had hospital admission for over 10 *** the multivariable analyses,hyponatraemia was associated with less dependency(adjusted OR(aOR)=0.35(95%CI 0.17 to 0.69))but longer admissions(aOR=3.2(1.8 to 5.7)).World Federation of Neurosurgical Societies grade I-III,modified Fisher 2-4 and posterior circulation aneurysms were associated with greater hazards of *** In this comprehensive multicentre prospective-adjusted analysis of patients with SAH,hyponatraemia was investigated inconsistently and,for most patients,was not associated with changes in management or clinical outcome.T

关键词： admitted urine centre

Insulin action in muscle and adipose tissue in type 2 diabetes:The significance of blood flow

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of diabetes 2015年第4期6卷 626-633页

作者： Vaia Lambadiari Konstantinos Triantafyllou George D Dimitriadis Second Department of Internal Medicine Research Institute and Diabetes CentreAttikon University General HospitalAthens University Medical School

Under normal metabolic conditions insulin stimulates microvascular perfusion(capillary recruitment) of skeletal muscle and subcutaneous adipose tissue and thus increases blood flow mainly after meal ingestion or physical *** helps the delivery of insulinitself but also that of substrates and of other signalling molecules to multiple tissues beds and facilitates glucose disposal and lipid *** effect is impaired in insulin resistance and type 2 diabetes early in the development of metabolic dysregulation and reflects early-onset endothelial *** of insulin to increase muscle and adipose tissue blood flow results in decreased glucose *** fat depots,a blunted postprandial blood flow response will result in an insufficient suppression of lipolysis and an increased spill over of fatty acids in the circulation,leading to a more pronounced insulin resistant state in skeletal *** defect in blood flow response is apparent even in the prediabetic state,implying that it is a facet of insulin resistance and exists long before overt hyperglycaemia *** following review intends to summarize the contribution of blood flow impairment to the development of the atherogenic dysglycemia and dyslipidaemia.

关键词： Insulin resistance Muscle blood flow Glucoseuptake Adipose tissue blood flow diabetes

Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m^(6)A methylation and increasing the stability of SREBF1 and ChREBP mRNAs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2022年第9期14卷 40-53页

作者： Zhili Tang Chao Sun Ying Yan Zhoumin Niu Yuying Li Xi Xu Jing Zhang Yuting Wu Yan Li Li Wang Cheng Hu Zhuoyang Li Jingjing Jiang Hao Ying CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of Sciencesand Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200031China Innovation Center for Intervention of Chronic Disease and Promotion of Health Shanghai 200031China Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghai 200031China State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxi 214122China Shanghai diabetes Institute Shanghai Key Laboratoryof Diabetes MelitusShanghai Clinical Centre for DiabetesShanghai jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Key Laboratory of Food Safety Risk Assessment Ministry of HealthBeijing 100021China

Previous studies have indicated an association of fat mass and obesity-associated(FTO)with nonalcoholic fatty liver disease(NAFLD),the most common chronic liver disease *** study aimed to decipher the complex role of FTO in hepatic lipid *** found that a decrease in N^(6)-methyladenosine(m^(6)A)RNA methylation in the liver of mice fed with a high-fat diet(HFD)was accompanied by an increase in FTO *** of FTO in the liver promoted triglyceride accumulation by upregulating the expression of lipogenic *** studies revealed that FTO could stabilize the mRNAs of sterol regulatory element binding transcription factor 1(SREBF1)and carbohydrate responsive element binding protein(ChREBP),two master lipogenic transcription factors,by demethylating m^(6)A *** ofeither SREBF1 or ChREBP attenuated the lipogenic effect of FTO,suggesting that they are bona fide effectors for FTO in regulating *** could stimulate FTO transcription through a mechanism involving the action of intranuclear insulin receptor beta,while knockdown of FTO abrogated the lipogenic effect of *** ofFTo by entacapone decreased the expression of SREBF1,ChREBP,and downstream lipogenic genes,ameliorating liver steatosis in HFD-fed ***,our study established a critical role of FTO in both the insulin-regulated hepatic lipogenesis and the pathogenesis of NAFLD and provided a potential strategyfor treating NAFLD.

关键词： FTO m^(6)A SREBF1 ChREBP lipogenesis NAFLD

Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2019年第1期17卷 57-65页

作者： Khaled M.M.Koriem Mahmoud S.Arbidb Hend N.Saleh Department of Medical Physiology National Research Centre Department of Pharmacology National Research Centre Faculty of Pharmacy Cairo University

Objective: Psidium guajava occurs worldwide in tropical and subtropical areas. It has been used to treat inflammation, diabetes, fever, hypertension and ulcers. However, its antidiarrheal and protein conservative activities still need to be ***: Fifty-four male rats were divided into normal and diarrheal rats. The normal rats were divided into 4 groups: control, low-dose P. guajava leaf extract(50 mg/kg), high-dose P. guajava leaf extract(100 mg/kg) and gallic acid. Treatments were administrated orally in 1 mL saline for a 1-month *** diarrheal rats were divided into 5 groups: desmopressin(0.2 mg/kg) drug, low-dose P. guajava leaf extract(50 mg/kg), high-dose P. guajava leaf extract(100 mg/kg), gallic acid and an untreated *** were given daily for a 1-month period while the untreated control received no ***: Diarrhea was responsible for an observed decline in kidney weight and serum sodium, potassium and chloride. Further, diarrhea was positively correlated with a significant increase in urine volume, and excretion of electrolytes, serum urea, creatinine and uric acid in the urine. In contrast, there was a proportional increase in the lipid peroxidation value in diarrhea and a significant decline was observed in serum superoxide dismutase, glutathione peroxidase and glutathione levels in diarrhea. Also, diarrhea inhibited blood proteins. The oral intake of P. guajava leaf extract by diarrheal rats restored all of these parameters to near normal levels. High-dose P. guajava leaf extract was more effective than the same compound at a low ***: P. guajava leaf extract elicited antidiarrheal and protein conservative effects.

关键词： Psidium guajava Myrtaceae Diarrhea Proteins Antioxidant