Development of innovative tools for investigation of nutrient-gut interaction

作     者：Wei-Kun Huang Cong Xie Richard L Young Jiang-Bo Zhao Heike Ebendorff-Heidepriem Karen L Jones Christopher K Rayner Tong-Zhi Wu 

作者机构：Adelaide Medical SchoolCentre of Research Excellence in Translating Nutritional Science to Good Healththe University of AdelaideAdelaideSA 5005Australia Institute for Photonics and Advanced SensingSchool of Physical SciencesUniversity of AdelaideAdelaideSA 5005Australia The ARC Centre of Excellence for Nanoscale BioPhotonicsAdelaideSA 5005Australia DiabetesNutrition and Gut HealthLifelong HealthSouth Australia Health and Medical Research InstituteAdelaideSA 5005Australia Department of Gastroenterology and HepatologyRoyal Adelaide HospitalAdelaideSA 5000Australia Department of EndocrinologyZhongda HospitalInstitute of DiabetesSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第25期

页      面：3562-3576页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Supported by the National Health and Medical Research Council(NHMRC)of Australia,No.APP1147333 the National Nature Science Foundation of China,No.81870561 the Hospital Research Foundation of Australia the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics,No.CE140100003 

主　　题：Nutrient-gut interaction Metabolic disorders Incretin hormones Enteroendocrine cells Enteroids Intestinal intubation Intestine-on-a-chip 

摘      要：The gastrointestinal tract is the key interface between the ingesta and the human *** is wide recognition that the gastrointestinal response to nutrients or bioactive compounds,particularly the secretion of numerous hormones,is critical to the regulation of appetite,body weight and blood *** concept has led to an increasing focus on“gut-basedstrategies for the management of metabolic disorders,including type 2 diabetes and *** the underlying mechanisms and downstream effects of nutrient-gut interactions is fundamental to effective translation of this knowledge to clinical *** this end,an array of research tools and platforms have been developed to better understand the mechanisms of gut hormone secretion from enteroendocrine *** review discusses the evolution of in vitro and in vivo models and the integration of innovative techniques that will ultimately enable the development of novel therapies for metabolic diseases.