Prospective,multicentre study of screening,investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland

作     者：James J M Loan Steven Tominey Kirun Baweja Julie Woodfield Thomas J G Chambers Mark Haley Simran S Kundu H Y Josephine Tang Anthony N Wiggins Michael T C Poon Paul M Brennan 

作者机构：Translational NeurosurgeryThe University of Edinburgh Centre for Clinical Brain SciencesEdinburghUK NeurosurgeryNHS LothianEdinburghUK NeurosurgeryInstitute of Neurological SciencesGlasgowUK Department of MedicineSchool of MedicineDentisty and NuringUniversity of GlasgowGlasgowUK Internal MedicineQueen's UniversityKingstonOntarioCanada Centre for Discovery Brain SciencesUniversity of EdinburghEdinburghUK Edinburgh Centre for Diabetes and EndocrinologyNHS LothianEdinburghUK RadiologyUniversity Hospitals Plymouth NHS TrustPlymouthUK Department of MedicineCork University HospitalUniversity College CorkCorkIreland 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2023年第8卷第3期

页      面：207-216,I0028-I0059页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：JJML is supported by a Wellcome Trust Fellowship Grant(214145/Z/18/Z) MTCP is supported by a Cancer Research UK Brain Tumour Centre of Excellence Award(C157/A27589) 

主　　题：admitted urine centre 

摘      要：Background Hyponatraemia often occurs after subarachnoid haemorrhage(SAH).However,its clinical significance and optimal management are *** audited the screening,investigation and management of hyponatraemia after *** We prospectively identified consecutive patients with spontaneous SAH admitted to neurosurgical units in the United Kingdom or *** reviewed medical records daily from admission to discharge,21 days or death and extracted all measurements of serum sodium to identify hyponatraemia(10 *** of hyponatraemia with outcome were assessed using logistic regression with adjustment for predictors of outcome after SAH and admission *** assessed hyponatraemia-free survival using multivariable Cox *** 175/407(43%)patients admitted to 24 neurosurgical units developed hyponatraemia.5976 serum sodium measurements were *** osmolality,urine osmolality and urine sodium were measured in 30/166(18%)hyponatraemic patients with complete *** most frequently target daily fluid intake was3 L and this did not differ during hyponatraemic or non-hyponatraemic episodes.26%(n/N=42/164)patients with hyponatraemia received sodium supplementation.133(35%)patients were dead or dependent within the study period and 240(68%)patients had hospital admission for over 10 *** the multivariable analyses,hyponatraemia was associated with less dependency(adjusted OR(aOR)=0.35(95%CI 0.17 to 0.69))but longer admissions(aOR=3.2(1.8 to 5.7)).World Federation of Neurosurgical Societies grade I-III,modified Fisher 2-4 and posterior circulation aneurysms were associated with greater hazards of *** In this comprehensive multicentre prospective-adjusted analysis of patients with SAH,hyponatraemia was investigated inconsistently and,for most patients,was not associated with changes in management or clinical outcome.T