检索结果-南通市图书馆

Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2014年第1期3卷 18-25页

作者： Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu Sichuan Provincial Center for Diseases Control and prevention ChengduSichuanChina Ganzi Prefecture Center for Diseases Control and prevention KangdingSichuanChina Institute of Parasitic Diseases China Center for Diseases Control and PreventionShanghaiChina who collaborating Center for prevention and treatment of human echinococcosis University Hospital and University of Franche-Comté25030 BesançonFrance Department of Chrono-Environment UMR UFC/CNRS 6249 aff.INRAUniversity of Franche-ComtéBesançonFrance Cestode Zoonoses Research Group Bioscience Research Institute and School of Environment and Life SciencesUniversity of SalfordGreat Manchester M54WTUK

Objective: echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were

关键词： Control options echinococcosis Qinghai-Tibet Plateau Risk factors

Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第17期15卷 2116-2124页

作者： Ren-Yong Lin Jun-Hua Wang Xiao-Mei Lu Xiao-Tao Zhou Georges Mantion Hao Wen Dominique A Vuitton Lysiane Richert Xinjiang Key Laboratory on echinococcosis and Liver Surgery 1st Teaching Hospital of Xinjiang Medical University No. 1 Liyushan Road Urumqi 830054 China Ren-Yong Lin Lysiane Richert Laboratoire de Toxicologie Cellulaire EA 4267 Faculte de Medecine et Pharmacie University of Franche-Comte Place Saint-Jacques 25030 Besangon France Liver Surgery and Transplantation Unit EA 3921 Department of Digestive Surgery University Hospital Jean Minjoz Boulevard Fleming 25030 Besangon France who-collaborating centre for the prevention and treatment of human echinococcosis University of Franche-Comte Place Saint Jacques 25030 Besancon France who-collaborating centre for the prevention and treatment of human echinococcosis University of Franche-Comte Place Saint Jacques 25030 Besancon France

AIM： To explore the effect of Echinococcusmultilocularis on the activation of mitogen-activated protein kinase （MAPK） signaling pathways and on livercell ***： Changes in the phosphorylation of MAPKs and proliferating cell nuclear antigen （PCNA）expression were measured in the liver of patients withalveolar echinococcosis （AE）. MAPKs, MEK1/2 [MAPK/extracellular signal-regulated protein kinase （ERK）kinase] and ribosomal S6 kinase （RSK） phosphorylationwere detected in primary cultures of rat hepatocytesin contact in vitro with （1） E. multilocu/aris vesicle fluid（EmF）, （2）E. multilocularis-conditioned medium （EmCM）.RESULTS： In the liver of AE patients, ERK 1/2 andp38 MAPK were activated and PCNA expression wasincreased, especially in the vicinity of the *** exposure to EmF, p38, c-Jun N-terminal kinase（JNK） and ERK1/2 were also activated in hepatocytesin vitro, as well as MEK1/2 and RSK, in the absenceof any toxic effect. Upon exposure to EmCM, only JNKwas ***： Previous studies have demonstratedan influence of the host on the MAPK cascade inE. multilocularis. Our data suggest that the reverse,i.e. parasite-derived signals efficiently acting onMAPK signaling pathways in host liver ceils, is actuallyoperating.

关键词： Echinococcus multilocularis Hepaticalveolar echinococcosis Mitogen-activated proteinkinase Host-parasite interactions Liver

Evaluation of intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第29期26卷 4302-4315页

作者： Tilmann Graeter Hai-Hua Bao Rong Shi Wen-Ya Liu Wei-Xia Li Yi Jiang Julian Schmidberger Eleonore Brumpt Eric Delabrousse Wolfgang Kratzer Department of Diagnostic and Interventional Radiology University Hospital UlmUlm 89081Germany Qinghai University Qinghai University First Affiliated HospitalXining 810001Qinghai ProvinceChina University First Affiliated HospitalWHO Collaborating Centre on Prevention and Care Management of EchinococcosisUrumqi 830054Xinjiang Uyghur Autonomous RegionChina Department of Internal Medicine I University Hospital UlmUlm 89081Germany who collaborating centre on prevention and treatment of human echinococcosis/National French Reference centre for echinococcosis University Bourgogne Franche-Comtéand Besançon University HospitalBesançon 25030France

BACKGROUND The main endemic areas of alveolar echinococcosis(AE)are in Central Europe and Western *** the infiltration of intrahepatic vascular and bile duct structures as well as extrahepatic disease can lead to further complications and may increase morbidity in patients with *** To evaluate vascular/biliary involvement in hepatic AE and its distant extrahepatic disease manifestations in an international collective was the *** Consecutively,five experienced examiners evaluated contrast-enhanced abdominal computed tomography(CT)scans for 200 patients with hepatic AE of each of four locations(n=50)in Germany,France and ***,we retrospectively included the 50 most recent abdominal contrast-enhanced CT examinations at each center,performed because of hepatic AE from September 21,2007 to March 21,*** liver lesions were classified according to the echinococcosis multilocularis Ulm classification for CT(EMUC-CT).Distant extrahepatic manifestations were documented either by whole body positron emission tomography–CT or with the addition of thoracic CT and cranial magnetic resonance ***/biliary involvement of the hepatic disease as well as the presence of distant extrahepatic manifestations were correlated with the EMUC-CT types of liver *** analysis was performed using SAS Version 9.4(SAS Institute Inc.,Cary,NC,United States).RESULTS Distant extrahepatic AE manifestations were significantly more frequent in China than in Europe(P=0.0091).A significant relationship was found between the presence of distant extrahepatic disease and AE liver lesion size(P=0.0075).Vascular/biliary structures were involved by the liver lesions significantly more frequently in China than in Europe(P<0.0001),and vascular/biliary involvement depended on lesion *** morphological types of AE liver lesions led to varying frequencies of vascular/biliary involvement and were associated with different frequencies of distant extrahe

关键词： Alveolar echinococcosis Echinococcus multilocularis Echinococcus multilocularis Ulm classification for computed tomography Vascular/biliary involvement Extrahepatic manifestation XUUB project

A historical view of alveolar echinococcosis, 160 years after the discovery of the first case in humans： part 1. What have we learnt on the distribution of the disease and on its parasitic agent？

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第18期124卷 2943-2953页

作者： Dominique Angele Vuitton WANG Qian ZHOU Hong-xia Francis Raoul Jenny Knapp Solange Bresson-Hadni WEN Hao Patrick Giraudoux who collaborating Center for prevention and treatment of human echinococcosis University Hospital and University of Francbe-Comte 25030 Besancon France Sichuan Center for Disease Control and prevention Chengdu Sichuan 610031 China Guangxi Medical University Nanning Guangxi 530021 China Chrono-Environnement Joint Research Unit UMR 6249 University of Franche-Comte CNRS and INRA 25030 Besancon France Xinjiang Key Laboratory for echinococcosis Research 1st Teaching Hospital of Xinjiang Medical University Urumqi Xiniianz 830000. China

Since the first 2 cases observed in southern Germany and the correct identification of a parasite at the origin of the disease by the famous scientist Rudolf Virchow in 1855, the borders of the endemic area of alveolar echinococcosis （AE） have never stopped to expand. The parasite was successively recognized in Switzerland, then in Russia, Austria and France which were long considered as the only endemic areas for the disease. Cases were disclosed in Turkey in 1939; then much attention was paid to Alaska and to Hokkaido, in Japan. The situation totally changed in 1991 after the recognition of the Chinese endemic areas by the international community of scientists. The world map was completed in the beginning of the 21st century by the identification of AE in most of the countries of central/eastern Europe and Baltic States, and by the recognition of cases in central Asia. Up to now, the disease has however never been reported in the South hemisphere and in the United Kingdom. In the mid-1950s, demonstration by Rausch and Schiller in Alaska, and by Vogel in Germany, of the distinction between 2 parasite species responsible respectively for cystic echinococcosis （＂hydatid disease＂） and AE put an end to the long-lasting debate between the ＂dualists＂, who believed in that theory which eventually proved to be true, and the ＂unicists＂, who believed in a single species responsible for both diseases. At the end of the 20th century, molecular biology fully confirmed the ＂dualist＂ theory while adding several new species to the initially described E. granulosus; within the past decade, it also confirmed that little variation existed within Echinococcus （E.） multilocularis species, and that AE-Iooking infection in some intermediate animal hosts on the Tibetan plateau was indeed due to a new species, distinct from E. multilocularis, named E. shiquicus. Since the 1970s, the unique ecological interactions between the landscape, the hosts, and E. multilocularis have progressively be

关键词： alveolar echinococcosis Echinococcus species epidemiology history Rudolf Virchow western China

Brucellosis Outbreak Caused by Brucella melitensis--Jingyang County,Shaanxi Province,China,March–May,2020

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2020年第39期2卷 753-756页

作者： Wenhui Chang Yangxin Sun Suoping Fan Cuihong An Shoumin Nie Guozhong Tian Boyan Luo Hongxun Yang Xiaohua Zhai Haiying Tian Jia Zhang Hai Jiang Shaanxi Provincial centre for Disease Control and prevention XianShaanxiChina State Key Laboratory for Infectious Disease prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Jingyang County centre for Disease Control and prevention XianyangShaanxiChina Xianyang City centre for Disease Control and prevention XianyangShaanxiChina.

What is already known about this topic?Brucellosis is one of the world’s most overlooked zoonotic diseases,and humans can easily acquire brucellosis from animals and their *** brucellosis outbreaks are probably attributable to sociocultural factors and compounded by the lack of adequate control measures in sheep and goat rearing *** is added by this report?This is the first identified outbreak caused by Brucella melitensis bv.3 in Jingyang County,Xianyang City,Shaanxi Province.A total of 13 seropositve cases(7 acute patients and 6 asymptomatic persons)were identified from March to May,2020,and the investigation indicated that sheep-to-canine-to-human was the likely transmission *** are the implications for public health practice?Effective control of sheep brucellosis will significantly reduce the risk of human *** should be given to building cooperation between all stakeholders,maintaining epidemiological surveillance to detect human brucellosis at medical centers,and making case reporting mandatory for both veterinary and public health services.

关键词： likely sheep centers

Impact of overgrazing on the transmission of Echinococcus multilocularis in Tibetan pastoral communities of Sichuan Province,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2007年第3期120卷 237-242页

作者： WANG Qian XIAO Yong-fu Dominique A Vuitton Peter M Schantz Francis Raoul Christine Budke Maiza Campos-Ponce Philip S Craig Patrick Giraudoux Sichuan centre for Disease Control and prevention Chengdu610041 China who collaborating centre for the prevention and treatment ofAlveolar echinococcosis SERF and LBE Usc INRA ResearchUnits University of Franche-Comte 25030-Besancon France Institute of Parasitology University of Zurich Winterthurerstrasse266a CH-8057 Zurich Switzerland Faculty of Earth and Life Sciences Free University AmsterdamNetherlands Cestode Zoonoses Research Group Bioscience Research Instituteand School of Environment and Life Sciences University ofSalford Salford MS4WT United Kingdom

Background Overgrazing was assumed to increase the population density of small mammals that are the intermediate hosts of Echinococcus multilocularis, the pathogen of alveolar echinococcosis in the Qinghai Tibet Plateau. This research tested the hypothesis that overgrazing might promote Echinococcus multilocularis transmission through increasing populations of small mammal, intermediate hosts in Tibetan pastoral communities. Methods Grazing practices, small mammal indices and dog Echinococcus multilocularis infection data were collected to analyze the relation between overgrazing and Echinococcus multilocularis transmission using nonparametric tests and multiple stepwise logistic regression. Results In the investigated area, raising livestock was a key industry. The communal pastures existed and the available forage was deficient for grazing. Open （common） pastures were overgrazed and had higher burrow density of small mammals compared with neighboring fenced （private） pastures; this high overgrazing pressure on the open pastures measured by neighboring fenced area led to higher burrow density of small mammals in open pastures. The median burrow density of small mammals in open pastures was independently associated with nearby canine Echinococcus multilocularis infection （P=-0.003, OR=1.048）. Conclusion Overgrazing may promote the transmission of Echinococcus multilocularis through increasing the population density of small mammals.

关键词： echinococcosis, hepatic Echinococcus multilocularis overgrazing Tibetan pastoral communities

HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2023年第5期36卷 418-430页

作者： CEN Ping LIANG Hua Yue YANG Yuan ZHANG Fei YANG Shi Xiong MO Ju Cong FENG Yi HUANG Jie Gang NING Chuan Yi HUANG Chun Yuan YANG Yao LIANG Na LIANG Bing Yu YE Li LIANG Hao Guangxi Key Laboratory of AIDS prevention and treatment School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Collaborative Innovation centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Life Science InstituteGuangxi Medical UniversityNanning 530021GuangxiChina Nanning Center for Disease Control and prevention Nanning 530023GuangxiChina State Key Laboratory of Infectious Disease prevention and Control(SKLID) Chinese Center for Disease Control and Prevention(China CDC)Collaborative Center for Diagnosis and Treatment of Infectious DiseaseBeijing 102206China

Objective The mode of human immunodeficiency virus(HIV) transmission via injection drug use(IDU)still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in *** We performed a molecular epidemiological investigation of infections across Guangxi from2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological *** Among the 535 subjects, CRF08_BC(57.4%), CRF01_AE(28.4%), and CRF07_BC(10.7%) were the top 3 HIV strains;72.6% of infections were linked to other provinces in the transmission network;93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces,predominantly Guangdong and Yunnan;92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive *** HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other *** of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened.

关键词： HIV-1 Injection drug use Transmission Strain source Phylogenetics

Research gaps for three main tropical diseases in the People’s Republic of China

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2013年第1期2卷 112-125页

作者： Qi Zheng Samantha Vanderslott Bin Jiang Li-Li Xu Cong-Shan Liu Le-Le Huo Li-Ping Duan Ning-Bo Wu Shi-Zhu Li Zhi-Gui Xia Wei-Ping Wu Wei Hu Hao-Bing Zhang National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionWHO Collaborating Centre on MalariaSchisostomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of Health207 Rui Jin Er RdShanghai 200025People’s Republic of China The Department of Science and Technology Studies University College LondonLondon WC1E 6BTUK

This scoping review analyzes the research gaps of three diseases:schistosomiasis japonica,malaria and *** on available data in the ***,we highlight the gaps between control capacity and prevalence levels,and between diagnostic/drug development and population need for treatment at different stages of the national control *** reviewing the literature from 848 original studies and consultations with experts in the field,the gaps were identified as ***,the malaria research gaps include(i)deficiency of active testing in the public community and no appropriate technique to evaluate elimination,(ii)lack of sensitive diagnostic tools for asymptomatic patients,(iii)lack of safe drugs for mass ***,gaps in research of schistosomiasis include(i)incongruent policy in the implementation of integrated control strategy for schistosomiasis,(ii)lack of effective tools for Oncomelania *** control,(iii)lack of a more sensitive and cheaper diagnostic test for large population samples,(iv)lack of new drugs in addition to ***,gaps in research of echinococcosis include(i)low capacity in field epidemiology studies,(ii)lack of sanitation improvement studies in epidemic areas,(iii)lack of a sensitivity test for early diagnosis,(iv)lack of more effective drugs for short-term *** believe these three diseases can eventually be eliminated in China's Mainland if all the research gaps are abridged in a short period of time.

关键词： Schistosomiasis Malaria echinococcosis Epidemiology Diagnosis Chemotherapy Research capacity building

Investigation on the Management for Patients with echinococcosis Treated with Albendazole-Three PLADs,China,2019

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2023年第20期5卷 437-441页

作者： Min Qin Liying Wang Ying Wang Xu Wang Jiaxi Lei Xixi Cheng Yu Feng Yanyan Hou Qian Wang Chuizhao Xue Laurent Gavotte Roger Frutos National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Espace-Dev UMR 228Universitéde MontpellierMontpellierFrance Cirad UMR 17IntertrypCampus international de BaillarguetMontpellierFrance Gansu Provincial Center for Disease Control and prevention Lanzhou CityGansu ProvinceChina Xinjiang Uygur Autonomous Region Center for Disease Control and prevention Urumqi CityXinjiang Uygur Autonomous RegionChina Sichuan Provincial Center for Disease Control and prevention Chengdu CitySichuan ProvinceChina

Summary What is already known about this topic?In China,patients with echinococcosis receive complimentary healthcare services,such as medical treatment,diagnostic examinations,and follow-up *** this,no studies have been conducted to assess the quality of patient management to *** is added by this report?This study reviewed the medical records of 899 patients who underwent albendazole treatment across 10 endemic *** of 634 evaluable patient files,the proportion of patients with a ratio of actual followup and reexamination times to theoretical follow-up and reexamination times≥0.8 were both low(21.92%and 23.19%,respectively).What are the implications for public health practices?This study identified weaknesses and specific issues in patient management and proposed feasible recommendations to enhance patient file documentation,follow-up,and reexamination.

关键词： treatment spite feasible