Evaluation of intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis
作者机构：Department of Diagnostic and Interventional RadiologyUniversity Hospital UlmUlm 89081Germany Qinghai UniversityQinghai University First Affiliated HospitalXining 810001Qinghai ProvinceChina UniversityFirst Affiliated HospitalWHO Collaborating Centre on Prevention and Care Management of EchinococcosisUrumqi 830054Xinjiang Uyghur Autonomous RegionChina Department of Internal Medicine IUniversity Hospital UlmUlm 89081Germany WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis/National French Reference Centre for EchinococcosisUniversity Bourgogne Franche-Comtéand Besançon University HospitalBesançon 25030France
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2020年第26卷第29期
页 面：4302-4315页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by a German Research Foundation funded project called“Establishment of a national database for alveolar echinococcosis”,No.KA 4356/3-1 “Implementation of interfaces for the standardization of nationaldatabase systems for alveolar echinococcosis and its transformation processes”,No.KR 5204/1-2 Multiple imaging study of the Hepatic Alveolar Echinococcosis after albendazole treatment,the Qinghai Science and Technology Department,No.2017-SF-158 and the Müller Holding Ltd.and Co.KG Ulm
主 题：Alveolar echinococcosis Echinococcus multilocularis Echinococcus multilocularis Ulm classification for computed tomography Vascular/biliary involvement Extrahepatic manifestation XUUB project
摘 要：BACKGROUND The main endemic areas of alveolar echinococcosis(AE)are in Central Europe and Western *** the infiltration of intrahepatic vascular and bile duct structures as well as extrahepatic disease can lead to further complications and may increase morbidity in patients with *** To evaluate vascular/biliary involvement in hepatic AE and its distant extrahepatic disease manifestations in an international collective was the *** Consecutively,five experienced examiners evaluated contrast-enhanced abdominal computed tomography(CT)scans for 200 patients with hepatic AE of each of four locations(n=50)in Germany,France and ***,we retrospectively included the 50 most recent abdominal contrast-enhanced CT examinations at each center,performed because of hepatic AE from September 21,2007 to March 21,*** liver lesions were classified according to the echinococcosis multilocularis Ulm classification for CT(EMUC-CT).Distant extrahepatic manifestations were documented either by whole body positron emission tomography–CT or with the addition of thoracic CT and cranial magnetic resonance ***/biliary involvement of the hepatic disease as well as the presence of distant extrahepatic manifestations were correlated with the EMUC-CT types of liver *** analysis was performed using SAS Version 9.4(SAS Institute Inc.,Cary,NC,United States).RESULTS Distant extrahepatic AE manifestations were significantly more frequent in China than in Europe(P=0.0091).A significant relationship was found between the presence of distant extrahepatic disease and AE liver lesion size(P=0.0075).Vascular/biliary structures were involved by the liver lesions significantly more frequently in China than in Europe(P0.0001),and vascular/biliary involvement depended on lesion *** morphological types of AE liver lesions led to varying frequencies of vascular/biliary involvement and were associated with different frequencies of distant extrahe
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