HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China

作     者：CEN Ping LIANG Hua Yue YANG Yuan ZHANG Fei YANG Shi Xiong MO Ju Cong FENG Yi HUANG Jie Gang NING Chuan Yi HUANG Chun Yuan YANG Yao LIANG Na LIANG Bing Yu YE Li LIANG Hao CEN Ping;LIANG Hua Yue;YANG Yuan;ZHANG Fei;YANG Shi Xiong;MO Ju Cong;FENG Yi;HUANG Jie Gang;NING Chuan Yi;HUANG Chun Yuan;YANG Yao;LIANG Na;LIANG Bing Yu;YE Li;LIANG Hao

作者机构：Guangxi Key Laboratory of AIDS Prevention and TreatmentSchool of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and MinistryLife Science InstituteGuangxi Medical UniversityNanning 530021GuangxiChina Nanning Center for Disease Control and PreventionNanning 530023GuangxiChina State Key Laboratory of Infectious Disease Prevention and Control(SKLID)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Center for Diagnosis and Treatment of Infectious DiseaseBeijing 102206China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2023年第36卷第5期

页      面：418-430页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：National Natural Science Foundation of China [grant no. 82060610] National Natural Science Foundation of China [grant no. 82103899] Guangxi Scientific and Technological Key Project[Gui Ke AB19245038] Guangxi Scientific and Technological Key Project [Guike 2022AC23005, 2022AC20031,2022JJA141110] Science and Technology Project of Nanning 

主　　题：HIV-1 Injection drug use Transmission Strain source Phylogenetics 

摘      要：Objective The mode of human immunodeficiency virus(HIV) transmission via injection drug use(IDU)still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in *** We performed a molecular epidemiological investigation of infections across Guangxi from2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological *** Among the 535 subjects, CRF08_BC(57.4%), CRF01_AE(28.4%), and CRF07_BC(10.7%) were the top 3 HIV strains;72.6% of infections were linked to other provinces in the transmission network;93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces,predominantly Guangdong and Yunnan;92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive *** HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other *** of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened.