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Update on imaging of Peutz-Jeghers syndrome

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World Journal of Gastroenterology 2014年第31期20卷 10864-10875页

作者： Catherine Tomas Philippe Soyer Anthony Dohan Xavier Dray Mourad Boudiaf Christine Hoeffel Department of Radiology H?pital Robert Debré51092 Reims Cedex France Department of Abdominal Imaging H?pital Lariboisière-AP-HP and Université Diderot Paris 775475 Paris Cedex 10 France Department of Digestive Diseases H?pital Lariboisière-AP-HP and Université Diderot-Paris 775475 Paris Cedex 10 France

Peutz-Jeghers syndrome(PJS) is a rare, autosomal dominant disease linked to a mutation of the STK 11 gene and is characterized by the development of benign hamartomatous polyps in the gastrointestinal tract in association with a hyperpigmentation on the lips and oral mucosa. Patients affected by PJS have an increased risk of developing gastrointestinal and extra-digestive cancer. Malignancy most commonly occurs in the smallbowel. Extra-intestinal malignancies are mostly breast cancer and gynecological tumors or, to a lesser extent, pancreatic cancer. These polyps are also at risk of acute gastrointestinal bleeding, intussusception and bowel obstruction. Recent guidelines recommend regular smallbowel surveillance to reduce these risks associated with PJS. Small-bowel surveillance allows for the detection of large polyps and the further referral of selected PJS patients for endoscopic enteroscopy or surgery. Video capsule endoscopy, double balloon pushed enteroscopy,multidetector computed tomography and magnetic resonance enteroclysis or enterography, all of which are relatively new techniques, have an important role in the management of patients suffering from PJS. This review illustrates the pathological, clinical and imaging features of small-bowel abnormalities as well as the role and performance of the most recent imaging modalities for the detection and follow-up of PJS patients.

关键词： Peutz-Jeghers syndrome Small-bowel disease Small bowel polyps Intussusception Double balloon enteroscopy Video capsule endoscopy Abdomen,Magnetic resonance Abdomen Computed tomography

Analytical modelling of the expansion of a solid obstacle interacting with a radiative shock

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High Power Laser Science and Engineering 2018年第2期6卷 123-132页

作者： Th.Michel E.Falize B.Albertazzi G.Rigon Y.Sakawa T.Sano H.Shimogawara R.Kumar T.Morita C.Michaut A.Casner R Barroso P.Mabey Y.Kuramitsu S.Laffite L.Van Box Som G.Gregori R.Kodama N.Ozaki P.Tzeferacos D.Lamb M.Koenig luli-cnrs ecole polytechniquecea:universite paris-saclayupmc univ paris 06:sorbonne universites-f-91128 palaiseau cedexFrance cea damdifF-91297 ArpajonFrance cea saclay dsm/irfu/service d'astrophysiqueF-91191 Gif-sur-YvetteFrance institute of laser engineering osaka universitySuitaOsaka 565-0871Japan faculty of engineering sciences kyushu university6-1 Kasuga-KoenKasugaFukuoka 816-8580Japan luth observatoire de parispsl research universitycnrsuniversite paris diderotSorbonne Paris Cite92190 MeudonFrance universite de bordeaux-cnrs-cea celia UMR 5107F-33405 TalenceFrance gepi observatoire de parispsl research universitycnrsuniversite paris diderotSorbonne Paris Cite75014 ParisFrance graduate school of engineering osaka universitySuitaOsaka 565-0871Japan lerma observatoire de parispsl research universitycnrssorbonne universitesUPMC Univ.Paris 06F-75005 ParisFrance clarendon laboratory university of oxfordParks RoadOxford OX1 3PUUK flash center for computational science university of chicagoIL 60637USA

In this paper, we present a model characterizing the interaction of a radiative shock(RS) with a solid material, as described in a recent paper(Koenig et al., Phys. Plasmas, 24, 082707(2017)), the new model is then related to recent experiments performed on the GEKKO XII laser facility. The RS generated in a xenon gas cell propagates towards a solid obstacle that is ablated by radiation coming from the shock front and the radiative precursor, mimicking processes occurring in astrophysical phenomena. The model presented here calculates the dynamics of the obstacle expansion,which depends on several parameters, notably the geometry and the temperature of the shock. All parameters required for the model have been obtained from experiments. Good agreement between experimental data and the model is found when spherical geometry is taken into account. As a consequence, this model is a useful and easy tool to infer parameters from experimental data(such as the shock temperature), and also to design future experiments.

关键词： high energy density physics laser–plasmas interaction modelling plasmas astrophysics plasma physics radiative hydrodynamics radiative shock

Tophaceous gout of the middle ear

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Journal of Otology 2019年第4期14卷 155-157页

作者： Stephane Gargula Guillaume Poillon Mary Daval Marc Williams Mathieu Veyrat Homa Adle-Biassette Denis Ayache Department of Otolaryngogy Head and Neck SurgeryFoundation Adolphe de Rothschild HospitalParisFrance Department of Neuroradiology Foundation Adolphe de Rothschild HospitalParisFrance Department of Pathology Lariboisiere HospitalParis DiderotParis-Cite-Sorbonne UniversityParisFrance

We present a very rare case of tophaceous gout of the middle ear causing conductive hearing loss,with special emphasis on Computed Tomography presentation.

关键词： Gout Middle ear Hearing loss Conductive hearing loss Computed tomography

Self-medication of achalasia with cannabis, complicated by a cannabis use disorder

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World Journal of Gastroenterology 2015年第20期21卷 6381-6383页

作者： Amandine Luquiens Nelson Lourenco Amine Benyamina Henri-Jean Aubin Hopital Paul Brousse-Addictologie 94804 Villejuif cedex France Service d'hepatogastroenterologie Hopital Saint Louisuniversite Denis Diderot Paris Ⅶ 75010 ParisFrance

Achalasia is a rare esophagus motility disorder. Medical, endoscopic and surgical treatments are available, but all endorse high relapse rates. No data has been published to date reporting a therapeutic effect of cannabis use neither in achalasia nor on its influence on manometric measurements. We report the case of a patient diagnosed with achalasia. He could benefit from a large panel of therapeutic interventions, but none of them was effective over the time. He first used cannabis at age 20 and identified benefits regarding achalasia symptoms. He maintained regular moderate cannabis use for 9 years, with minimal digestive inconvenience. A manometry performed without cannabis premedication was realized at age 26 and still found a cardiospasm. Cannabis use could explain the gap between functional symptoms assessment and manometry measurement. Further investigations are warranted to explore a therapeutic effect of cannabis in achalasia and possible influence on outcome measurements.

关键词： Achalasia Cannabis Treatment Manometry Addiction

IGS polar motion measurement accuracy

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Geodesy and Geodynamics 2017年第6期8卷 413-420页

作者： Jim Ray Paul Rebischung Jake Griffiths National Geodetic Survey Silver Spring MD USA IGN LAREG University Paris Diderot Sorbonne Paris Cite France Naval Research Laboratory Washington DC USA

We elaborate an error budget for the long-term accuracy of IGS（International Global Navigation Satellite System Service） polar motion estimates, concluding that it is probably about 25-30 μas（1-sigma）overall, although it is not possible to quantify possible contributions（mainly annual） that might transfer directly from aliases of subdaily rotational tide errors. The leading sources are biases arising from the need to align daily, observed terrestrial frames, within which the pole coordinates are expressed and which are continuously deforming, to the secular, linear international reference frame. Such biases are largest over spans longer than about a year. Thanks to the very large number of IGS tracking stations, the formal covariance errors are much smaller,around 5 to 10 μas. Large networks also permit the systematic frame-related errors to be more effectively minimized but not eliminated. A number of periodic errors probably also influence polar motion results, mainly at annual, GPS（Global Positioning System） draconitic, and fortnightly periods, but their impact on the overall error budget is unlikely to be significant except possibly for annual tidal aliases. Nevertheless, caution should be exercised in interpreting geophysical excitations near any of the suspect periods.

关键词： PM(Polar motion) GPS(Global Positioning System) EOPs(Earth orientation parameters) Accuracy IGS(International GNSS Service)

Field report:Sailing around the exhumed roots of the Mesozoic Patagonian paleo-accretionary wedge(Diego de Almagro Island,Chile)

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Geoscience Frontiers 2018年第5期9卷 1591-1594页

作者： Samuel Angiboust Jesus Munoz Institut de Physique du Globe de paris Sorbonne Paris CitéUniversity Paris DiderotCNRSF-75005ParisFrance GFZ German Research Centre for Geosciences D-14473PotsdamGermany Carrera de Geología Universidad Andres BelloSazie2119SantiagoChile

We undertook a boat expedition to explore the geological framework of a very remote, lesser-known island, in the Chilean Patagonia: the Diego de Almagro Island(latitude S51°330'). This uninhabited, ca.400 km^2 Island is one of the very rare exposures of the Mesozoic accretionary subduction complex along the Chilean margin. Unstable weather, strong winds, steep topography, and very dense vegetation make an on-land mission difficult. Careful preparation based on high-resolution satellite images is advised to optimize shore access and minimize risks of injury. Despite a relatively important degree of regional reequilibration of metamorphic assemblages due to sluggish exhumation through the forearc crust, our results have shown that the island is composed of a nappe stack of ocean-floor derived slivers of metasedimentary units that exhibit very different pressure-temperature-time paths during burial by subduction under the Chilean margin and subsequent exhumation. These rocks are witness to a complex thermal evolution of the subduction zone between Jurassic and Cretaceous times from granulite facies to blueschist facies conditions as well as multiple episodes of accretion at ca. 35 -40 km in depth for almost100 Ma over the Mesozoic era.

关键词： Patagonia Accretionary wedge Blueschists Subduction Chile

Linear quadratic optimal control of conditional McKean-Vlasov equation with random coefficients and applications

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Probability, Uncertainty and Quantitative Risk 2016年第1期1卷 252-277页

作者： Huyen Pham Laboratoire de Probabilites et Mod´eles Al`eatoires CNRSUMR 7599Universite Paris DiderotParisFrance CREST-ENSAE ParisFrance

We consider the optimal control problem for a linear conditional McKeanVlasov equation with quadratic cost *** coefficients of the system and the weighting matrices in the cost functional are allowed to be adapted processes with respect to the common noise *** closed-loop strategies are introduced,and following the dynamic programming approach in(Pham and Wei,Dynamic programming for optimal control of stochastic McKean-Vlasov dynamics,2016),we solve the problem and characterize time-consistent optimal control by means of a system of decoupled backward stochastic Riccati differential *** present several financial applications with explicit solutions,and revisit,in particular,optimal tracking problems with price impact,and the conditional mean-variance portfolio selection in an incomplete market model.

关键词： Stochastic McKean-Vlasov SDEs Random coefficients Linear quadratic optimal control Dynamic programming Riccati equation Backward stochastic differential equation

HLA and lung transplantation

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Frontiers of Medicine 2019年第3期13卷 298-313页

作者： Liya Ju Caroline Suberbielle Xiaofan Li Nuala Mooney Dominique Charron HLA et Medecine "Jean Daus set" Laboratory NetworkHopital Saint-LouisParisFrance Laboratoire Histocompatibilité Hopital Saint-LouisParisFrance INSERM U1160 Hopital Saint-LouisUniversité Paris DiderotSorbonne Paris CitéFrance Labex Transplantex StrasbourgFrance Shanghai Jiao Tong university School of Medicine Shanghai 200025China

Lung transplantation is increasingly practiced for patients with end-stage lung *** successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies,mainly directed against the protein products of the HLA complex of the organ *** the association between antibody mediated rejection and ailograft damage has been well established in renal and heart transplantation,it has not yet been well characterized in lung *** review addresses the question of HLA matching in lung transplantation and current knowledge of the allogenicity of different HLA class Ⅰ and Ⅱ *** role of the antibody mediated immune response is discussed as well as the importance of pre-transplant or de novo posttransplant circulating ***,potential mechanisms,which may act individually or in combination,of antibody mediated damage to solid organ transplants are considered.

关键词： human leukocyte antigen class I and II lung transplantation mismatch obliterans bronchiolitis alloantibody antibody mediated rejection

Extrahepatic hepcidin production:The intriguing outcomes of recent years

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World Journal of Clinical Cases 2019年第15期7卷 1926-1936页

作者： Raêd Daher Thibaud Lefebvre HervéPuy Zoubida Karim Universitéparis diderot Bichat siteParis 75018France Inflammation Research Center(CRI) INSERM U1149/ERL CNRS 8252Paris 75018France Laboratory of Excellence GR-ExParis 75018France

Hepcidin is the hyposideremic hormone regulating iron *** is a defensin-like disulfide-bonded peptide with antimicrobial *** main site of hepcidin production is the liver where its synthesis is modulated by iron,inflammation and erythropoietic ***,hepcidin locally produced in several peripheral organs seems to be an important actor for the maintenance of iron homeostasis in these *** review highlights the presence of peripheral hepcidin and its potential *** the role of extrahepatic hepcidin could be of great physiological and therapeutic importance for several specific pathologies.

关键词： Hepcidin Extrahepatic hepcidin Iron metabolism Bacterial infection Inflammation