HLA and lung transplantation
作者机构：HLA et Medecine"Jean Daus set" Laboratory NetworkHopital Saint-LouisParisFrance Laboratoire HistocompatibilitéHopital Saint-LouisParisFrance INSERM U1160Hopital Saint-LouisUniversité Paris DiderotSorbonne Paris CitéFrance Labex TransplantexStrasbourgFrance Shanghai Jiao Tong University School of MedicineShanghai 200025China
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2019年第13卷第3期
页 面：298-313页
核心收录：
学科分类：10[医学]
主 题：human leukocyte antigen class I and II lung transplantation mismatch obliterans bronchiolitis alloantibody antibody mediated rejection
摘 要：Lung transplantation is increasingly practiced for patients with end-stage lung *** successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies,mainly directed against the protein products of the HLA complex of the organ *** the association between antibody mediated rejection and ailograft damage has been well established in renal and heart transplantation,it has not yet been well characterized in lung *** review addresses the question of HLA matching in lung transplantation and current knowledge of the allogenicity of different HLA class Ⅰ and Ⅱ *** role of the antibody mediated immune response is discussed as well as the importance of pre-transplant or de novo posttransplant circulating ***,potential mechanisms,which may act individually or in combination,of antibody mediated damage to solid organ transplants are considered.
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