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Frontiers of Medicine 2019年第3期13卷 298-313页

作者： Liya Ju Caroline Suberbielle Xiaofan Li Nuala Mooney Dominique Charron HLA et Medecine "Jean Daus set" Laboratory NetworkHopital Saint-LouisParisFrance Laboratoire Histocompatibilité Hopital Saint-LouisParisFrance INSERM U1160 Hopital Saint-LouisUniversité Paris DiderotSorbonne Paris CitéFrance Labex Transplantex StrasbourgFrance Shanghai Jiao Tong University School of Medicine Shanghai 200025China

Lung transplantation is increasingly practiced for patients with end-stage lung *** successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies,mainly directed against the protein products of the HLA complex of the organ *** the association between antibody mediated rejection and ailograft damage has been well established in renal and heart transplantation,it has not yet been well characterized in lung *** review addresses the question of HLA matching in lung transplantation and current knowledge of the allogenicity of different HLA class Ⅰ and Ⅱ *** role of the antibody mediated immune response is discussed as well as the importance of pre-transplant or de novo posttransplant circulating ***,potential mechanisms,which may act individually or in combination,of antibody mediated damage to solid organ transplants are considered.

关键词： human leukocyte antigen class I and II lung transplantation mismatch obliterans bronchiolitis alloantibody antibody mediated rejection

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Antibodies against major histocompatibility complex class I-related chain A in transplant recipients

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Chinese Medical Journal 2011年第5期124卷 764-770页

作者： Yizhou Zou Peter Stastny Transplantation Immunology Division Department of Internal Medicine University of Texas Southwestern Medical Center USA

Objective To review the role of polymorphism of major histocompatibility complex class I-related chain A （MICA） gene and antibodies against MICA antigens in transplant immunology. Data sources The data used in this review were mainly from our own results and from the relevant English language literatures published from 1999 to 2010. Some data presented in this review are in *** selection Articles regarding MICA gene discovery and pioneering finding of antibodies against MICA antigen and allograft rejection were selected. This review chronicles the development of our understanding of the role that MICA antigens and antibodies may play in organ *** Polymorphic glycoprotein MICA antigens were detected on freshly isolated human umbilical cord endothelial cells, but not on peripheral lymphocytes. Antibodies were found and typing of recipients and donors by sequencing the MICA alleles has established that de novo antibodies produced in kidney transplant recipients are directed at mismatched MICA epitopes and are associated with acute rejection and chronic transplant failure. The specificity of antibodies against the epitopes of MICA antigens were well characterized by donor MICA typing, single antigen array testing with antibody absorption and elution. Acute graft-versus-host disease was observed in stem-cell recipients who were mismatched for *** Immunization against mismatched MICA epitopes encountered in donor organs after transplantation may result in antibodies against MICA alleles. Testing for MICA donor-specific antibodies （DSA） which are associated with early failure of kidney transplants may be helpful for identifying some of the targets of antibodies against antigens other than the human leukocyte antigen （HLA） and for improving transplantation outcome.

关键词： major histocompatibility complex class 1-related chain A alloantibody transplantation

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