Update on imaging of Peutz-Jeghers syndrome

作     者：Catherine Tomas Philippe Soyer Anthony Dohan Xavier Dray Mourad Boudiaf Christine Hoeffel 

作者机构：Department of Radiology H?pital Robert Debré51092 Reims Cedex France Department of Abdominal Imaging H?pital Lariboisière-AP-HP and Université Diderot Paris 775475 Paris Cedex 10 France Department of Digestive Diseases H?pital Lariboisière-AP-HP and Université Diderot-Paris 775475 Paris Cedex 10 France 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第31期

页      面：10864-10875页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Peutz-Jeghers syndrome Small-bowel disease Small bowel polyps Intussusception Double balloon enteroscopy Video capsule endoscopy Abdomen,Magnetic resonance Abdomen Computed tomography 

摘      要：Peutz-Jeghers syndrome(PJS) is a rare, autosomal dominant disease linked to a mutation of the STK 11 gene and is characterized by the development of benign hamartomatous polyps in the gastrointestinal tract in association with a hyperpigmentation on the lips and oral mucosa. Patients affected by PJS have an increased risk of developing gastrointestinal and extra-digestive cancer. Malignancy most commonly occurs in the smallbowel. Extra-intestinal malignancies are mostly breast cancer and gynecological tumors or, to a lesser extent, pancreatic cancer. These polyps are also at risk of acute gastrointestinal bleeding, intussusception and bowel obstruction. Recent guidelines recommend regular smallbowel surveillance to reduce these risks associated with PJS. Small-bowel surveillance allows for the detection of large polyps and the further referral of selected PJS patients for endoscopic enteroscopy or surgery. Video capsule endoscopy, double balloon pushed enteroscopy,multidetector computed tomography and magnetic resonance enteroclysis or enterography, all of which are relatively new techniques, have an important role in the management of patients suffering from PJS. This review illustrates the pathological, clinical and imaging features of small-bowel abnormalities as well as the role and performance of the most recent imaging modalities for the detection and follow-up of PJS patients.