检索结果-南通市图书馆

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

引用

Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

引用

Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano Serena Boccella Carmela Belardo Andrea Maria Morace Francesca Guida Sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy universitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

引用

Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia La Barbera Paraskevi Krashia Annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism

引用

Neural Regeneration Research 2025年第1期20卷 41-53页

作者： Alessio Canovai Pete A.Williams Department of Biology University of PisaPisaItaly Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden

Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/*** quinone is present in the diet being available in foodstuffs,conferring the potential of this compound to be supplemented by dietary *** quinone’s nutritional role in mammalian health is supported by the extensive deficits in reproduction,growth,and immunity resulting from the dietary absence of pyrroloquinoline quinone,and as such,pyrroloquinoline quinone has been considered as a“new vitamin.”Although the classification of pyrroloquinoline quinone as a vitamin needs to be properly established,the wide range of benefits for health provided has been reported in many *** this respect,pyrroloquinoline quinone seems to be particularly involved in regulating cell signaling pathways that promote metabolic and mitochondrial processes in many experimental contexts,thus dictating the rationale to consider pyrroloquinoline quinone as a vital compound for mammalian *** the regulation of different metabolic mechanisms,pyrroloquinoline quinone may improve clinical deficits where dysfunctional metabolism and mitochondrial activity contribute to induce cell damage and *** quinone has been demonstrated to have neuroprotective properties in different experimental models of neurodegeneration,although the link between pyrroloquinoline quinone-promoted metabolism and improved neuronal viability in some of such contexts is still to be fully ***,we review the general properties of pyrroloquinoline quinone and its capacity to modulate metabolic and mitochondrial mechanisms in physiological *** addition,we analyze the neuroprotective properties of pyrroloquinoline quinone in different neurodegenerative conditions and consider future perspectives for pyrroloquinoline quinone’s potential in health and disease.

关键词： metabolism mitochondria neurodegenerative disease neuroprotection pyrroloquinoline quinone retinal diseases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

引用

Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： Elena Ambrosini Angela Lanciotti Maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Global-in-time Uniform Convergence for Linear Hyperbolic-Parabolic Singular Perturbations

引用

Acta Mathematica Sinica,English Series 2006年第4期22卷 1161-1170页

作者： Marina GHISI Massimo GOBBINO universitàdegli Studi di pisa Dipartimento di Matematicavia M.Buonarroti 256127 PISAItaly universitàdegli Studi di pisa Dipartimento di Matematica Applicata "Ulisse Dini"via Bonanno 25/B56126 PISAItaly

We consider the Cauchy problem εu^″ε ＋ δu′ε ＋ Auε = 0, uε（0） = uo, u′ε（0） = ul, where ε 〉 0, δ 〉 0, H is a Hilbert space, and A is a self-adjoint linear non-negative operator on H with dense domain D（A）. We study the convergence of （uε） to the solution of the limit problem ,δu＇＋ Au = 0, u（0） = u0. For initial data （u0, u1） ∈ D（A1/2）× H, we prove global-in-time convergence with respect to strong topologies. Moreover, we estimate the convergence rate in the case where （u0, u1）∈ D（A3/2） ∈ D（A1/2）, and we show that this regularity requirement is sharp for our estimates. We give also an upper bound for ｜u′ε（t）｜ which does not depend on ε.

关键词： Parabolic equations Damped hyperbolic equations Singular perturbations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new chelonibiid from the Miocene of Zanzibar (Eastern Africa) sheds light on the evolution of shell architecture in turtle and whale barnacles (Cirripedia: Coronuloidea)

引用

Integrative Zoology 2022年第1期17卷 24-43页

作者： Alberto COLLARETA William A.NEWMAN Giulia BOSIO Giovanni COLETTI dipartimento di Scienze della Terra Universitàdi PisaPisaItaly Museo di Storia Naturale Universitàdi PisaCalciItaly MBRD Scripps Institution of OceanographyLa JollaCaliforniaUSA dipartimento di Scienze dell’Ambiente e della Terra Universitàdegli Studi di Milano-BicoccaMilanoItaly

The fossil history of turtle and whale barnacles(Coronuloidea:Chelonibiidae,Platylepadidae,Coronulidae and†Emersoniidae)is fragmentary and has only been investigated in *** inferences and molecular phylogenetic analyses on extant specimens suggest that the roots of whale barnacles(Coronulidae)are to be found among the chelonibiid turtle barnacles,but the hard-part modifications that enabled early coronuloids to attach to the cetacean skin are still largely to be ***,we reappraise a fossil chelonibiid specimen from the Miocene of insular Tanzania that was previously referred to the living species Chelonibia *** largely forgotten specimen is here described as the holotype of the new species†Chelonibia *** similar to ***,†*** exhibits obvious external longitudinal parietal canals occurring in-between external longitudinal parietal septa that abut outwards to form T-shaped flanges,a character so far regarded as proper of the seemingly more derived Coronulidae and *** with these features,the presence of a substrate imprint on the shell exterior indicates that†*** grasped its host’s integument in much the same way as coronulids and platylepadids,albeit without the development of macroscopic parietal buttresses and *** section analyses of the inner parietal architecture of some extant and extinct coronuloids conclusively demonstrate that vestiges of comparable external parietal microstructures are present in some living members of *** observation strengthens the unity of Coronuloidea while significantly contributing to our understanding of the evolution of the coronuloid shell structure in adapting to a diverse spectrum of hosts.

关键词： †Chelonibia zanzibarensis sp.nov. epibiosis evolution functional morphology systematics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Charm mixing from BABAR

引用

Chinese Physics C 2008年第6期32卷 463-469页

作者： N.Neri BABAR Collaboration Universitàdi Pisa and INFNL.Bruno Pontecorvo 356127 PisaItaly

We present recent results from BABAR experiment for D^0-D^0mixing measurements. Mixing parameters can be measured in different ways using different D^ decay modes, here we discuss the most sensitive analyses such as D^0→ K^＋π^- where we had the first evidence of charm mixing, the measurement of the ratio of lifetimes of the decays D^0→ K^K^ and D^0→π^＋π^- relative to D^0→ K^-π^＋, the time dependent Dalitz plot analysis of D^0→K^＋π^-π^0. New limits on CP-violating time-integrated asymmetries in Do→ K^＋K^- and D^0→π^＋π^- are also discussed. The analyses presented are based on 384 fb^-1 data collected with the BABAR detector at the PEP-II asymmetric B Factory.

关键词： charm mixing flavor oscillations D^0 mesons BABAR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ritt's theorem and the Heins map in hyperbolic complex manifolds

引用

Science China Mathematics 2005年第z1期48卷 238-243页

作者： Marco Abate Filippo Bracci dipartimento di Matematica università di pisa Largo Pontecorvo 556127 PisaItalyDipartimento di Matematica Università di Roma "Tor Vergata"Via della Ricerca Scientifica00133 RomaItaly

Let X be a Kobayashi hyperbolic complex manifold, and assume that X does not contain compact complex submanifolds of positive dimension (e.g., X Stein). We shall prove the following generalization of Ritt's theorem: every holomorphic self-map f: X →X such that f(X) is relatively compact in X has a unique fixed point τ(f) ∈ X, which is attracting. Furthermore, we shall prove that τ(f) depends holomorphically on f in a suitable sense, generalizing results by Heins, Joseph-Kwack and the second author.

关键词： holomorphic self-map, fixed point, Wolff point, Ritt's theorem, Heins map, Stein manifold.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On the Regularity of Shear Thickening Viscous Fluids

引用

Chinese Annals of Mathematics,Series B 2009年第3期30卷 273-280页

作者： Francesca CRISPO dipartimento di Matematica Applicata "U.dini" Università di PisaVia Buonarroti 1/c56127 PisaItaly.

The aim of this note is to improve the regularity results obtained by H. Beirao da Veiga in 2008 for a class of p-fluid flows in a cubic domain. The key idea is exploiting the better regularity of solutions in the tan... 详细信息

关键词： Non-Newtonian fluids Shear dependent viscosity Boundary regularity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：