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Spatial and temporal patterns of forest fires in the Central monte:relationships with regional climate

Ecological Processes 2024年第1期13卷 66-79页

作者： Pablo Eugenio Villagra Erica Cesca Leandro manuel Alvarez Silvia delgado Ricardo Villalba Instituto Argentino de Nivología Glaciología y ciencias Ambientales–CONICET-CCT mendoza facultad de ciencias Agrarias universidad nacional de cuyo

Background Natural and anthropogenic wildfires burn large areas of arid and semi-arid forests with significant socio-economic and environmental impacts. Fire regimes are controlled by climate, vegetation type, and anthropogenic factors such as ignition sources and human-induced disturbances. Projections of climate and land-use change suggest that these controlling factors will change, altering fire regimes in the near future. In the southern Central monte, mendoza, argentina, the factors that modulate the fire temporal and spatial variability are poorly understood. We reconstructed the fire history of southeast of mendoza from 1984 to 2023 and investigated the relationships between fire extent and climate variability at seasonal and interannual scales. Burned areas were determined using Google Earth Engine by processing Landsat 5-Tm, Landsat 7-ETm+, and Landsat 8-OLI-TIRS sensor *** The region exhibited high spatial and temporal variability in fire occurrence, being a mosaic of areas with different fire histories and recovery times. Between 1985 and 2023, fire recurrence ranged from sites unburned to sites with up to 14 fires. The occurrence of large fires was strongly favored by a combination of a year with abundant spring–early summer precipitation, which favors fuel accumulation, followed by a year of low spring–early summer precipitation. Precipitation and burnt area showed a very pronounced 6–7 year cycle, suggesting a dominant climatic control on fire *** Fire distribution in southeastern mendoza forests is not homogeneous, resulting in a mosaic of patches with different fire histories. This heterogeneity may be related to vegetation patterns and land use. The temporal variability of fires is strongly influenced by climate variability, which would promote fuel production and subsequent drying. Large fires are concentrated in periods of high interannual precipitation variability. Climate change scenarios predict an increase in tem

关键词： Fire recurrence Fire mapping Recovery time Climate Dry forest Wildfire

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Sodium-glucose cotransporter-2 inhibitors protect tissues via cellular and mitochondrial pathways:Experimental and clinical evidence

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World Journal of Experimental medicine 2024年第2期14卷 46-52页

作者： Raúl Lelio Sanz Sebastián García menéndez Felipe Inserra Leon Ferder Walter manucha department of Pathology Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendoza 5500Argentina department of Pharmacology Instituto de Medicina y Biología Experimental de CuyoCentro Científico TecnológicoMendoza 5500Argentina department of Nephrology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina department of Cardiology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina

mitochondrial dysfunction is a key driver of cardiovascular disease(CVD)in metabolic syndrome and *** dysfunction promotes the production of reactive oxygen species(ROS),which cause oxidative stress and *** II,the main mediator of the renin-angiotensin-aldosterone system,also contributes to CVD by promoting ROS *** activity of sirtuins(SIRTs),a family of proteins that regulate cellular metabolism,also worsens oxidative *** of energy production by mitochondria is a common feature of all metabolic *** SIRT levels and 5’adenosine monophosphate-activated protein kinase signaling stimulate hypoxia-inducible factor 1 beta,which promotes ***,in turn,increases autophagy and mitophagy,processes that clear cells of debris and protect against *** cotransporter-2 inhibitors(SGLT2i),a class of drugs used to treat type 2 diabetes,have a beneficial effect on these *** clinical trials have shown that SGLT2i improves cardiac function and reduces the rate of cardiovascular and renal ***2i also increase mitochondrial efficiency,reduce oxidative stress and inflammation,and strengthen *** findings suggest that SGLT2i hold great potential for the treatment of ***,they are proposed as anti-aging drugs;however,rigorous research is needed to validate these preliminary findings.

关键词： Sodium-glucose cotransporter-2 inhibitors Cardiovascular diseases Sirtuins Oxidative stress Inflammation mitochondrial dysfunction

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez maría Fernanda González Ana maría Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

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World Journal of Clinical Oncology 2024年第2期15卷 195-207页

作者： Angeles C Tecalco-Cruz Karen H medina-Abreu Enrique Oropeza-martínez Jesus Zepeda-Cervantes AleidaVázquez-macías marina macías-Silva Posgrado en ciencias Genómicas Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico facultad de medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Colegio de ciencias y Humanidades Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Instituo de Fisiología celular Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of *** deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer *** particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γ*** this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in ***,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus *** addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.

关键词： Interferon-gamma IFNGR1 JAK1 Antiviral Anti-tumor Lung adenocarcinoma

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Sex-dependent resilience to extreme drought events: implications for climate change adaptation of a South American endangered tree species

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Ecological Processes 2024年第2期 48-60页

作者： Sergio Piraino martín Ariel Hadad yanina Antonia Ribas-Fernández Fidel Alejandro Roig Laboratorio de dendrocronología e Historia Ambiental (IANIGLA CONICET ) facultad de ciencias Agrarias Universidad Nacional de Cuyo Laboratorio de dendrocronología de Zonas áridas (CIGEOBIO CONICET ) Gabinete de Geología Ambiental (INGEO UNSJ) Hémera Centro de Observación de la Tierra Facultad de Ciencias Universidad Mayor

Background Recent changes in climatic trends are resulting in an increased frequency and intensity of extreme events, with unknown effect on ecosystem dynamics in the near future. Extreme drought episodes are recognized as disturbance factors capable of modifying forest dynamics and tree growth. Within this context, dioecious tree species may be impacted by climatic extremes, affecting male/female proportions and, consequently, reproductive processes and species persistence. Therefore, there is an urgent need for species-specific assessments of growth tolerance to extreme dry spells in dioecious tree species, to establish effective conservation strategies for these particular natural resources. Araucaria araucana(araucaria), an endangered dioecious Patagonian tree species, has recently undergone decay and mortality episodes in response to increasing dry climatic conditions. While sex-dependent tolerance to extreme drought episodes has been assessed in the species' humid distribution range, there is still a lack of information on the gender-based resilience of trees growing in the drier environments of the species' *** We reconstructed, through dendrochronological methods, the sex-dependent response of 105 araucaria individuals(55 female and 50 male trees) to five regional extreme dry spells employing a set of different indices. Resistance, recovery period, and average growth reduction of standardized tree-ring growth were examined, analysing the effect of biotic(sex, pre-drought stem tree growth) and abiotic(local climatic conditions before, during, and after extreme climatic episodes) factors on tree *** Sex influences only the species resistance to climatic disturbance, with male individuals showing lower tolerance to extreme drought events. Pre-drought radial growth rates and local meteorological conditions preceding, during, and following extreme dry spells strongly modulated araucaria radial growth resilience regardless of tree s

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Exocytosis,endocytosis and recycling of secretory vesicles in neuroendocrine cells,and its regulation by cortical actin

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BIOCELL 2022年第8期46卷 1867-1873页

作者： ANA m.CÁRdeNAS I.GALLO FERNANDO D.mARENGO Centro Interdisciplinario de Neurociencia de Valparaíso Facultad de CienciasUniversidad de ValparaísoValparaíso2360102Chile Instituto de Fisiología Biología Molecular y NeurocienciasCONICET.Departamento de Fisiología y Biología Molecular y CelularFacultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires1428Argentina

The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to *** dynamic network of cortical filaments,together with motor myosin partners,adjusts the plasmalemma tension,organizes membrane protein microdomains,remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis,endocytosis and recycling of secretory *** this review,we discuss how these mechanisms work in secretory cells.

关键词： Cortical actin Neuroendocrine cell Chromaffin cell Exocytosis Endocytosis

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Leishmaniasis in the Argentine Republic: Temporal and geographical distribution from 2013 to 2017

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Asian Pacific Journal of Tropical medicine 2019年第7期12卷 300-305页

作者： Germanómaría J Salomón maría C Neira Gisela Lozano Esteban mackern-Oberti Juan P Cargnelutti Diego E Consejo nacional de Investigaciones Científicas y Técnicas Centro Científico y Tecnológico de MendozaInstituto de Medicina y Biología Experimental de CuyoMendozaArgentina universidad nacional de cuyo Facultad de Ciencias Médicasárea de ParasitologíaMendozaArgentina universidad Juan Agustín maza Facultad de Ciencias Veterinarias y AmbientalesCentro de Investigación en Parasitología RegionalMendozaArgentina universidad nacional de cuyo Facultad de Ciencias MédicasInstituto de FisiologíaMendozaArgentina

Objective: To assess the temporal and geographical distribution of confirmed cases of cutaneous, mucocutaneous and visceral leishmaniasis in the Argentine Republic from 2013 to 2017. methods: A retrospective study was carried out using data collected from the Integrated Surveillance Bulletin database of the National System of Health Surveillance. Confirmed cases of cutaneous, mucocutaneous and visceral leishmaniasis up to the 52 nd epidemiological week of each year was included. Results: In the 5 years period, 1 295 confirmed leishmaniasis cases were reported in the Argentine Republic. One thousand twenty-eight(1 028) cases corresponded to cutaneous leishmaniasis(87.10%), being the most common type of leishmaniasis. mucocutaneous leishmaniasis was in the second place in the country with 115 cases reported, mostly in the Northwest and Northeast regions. A total of 52 individuals with visceral leishmaniasis were identified and misiones Province was the most affected. Conclusions: It is important to analyze the temporal and geographical distribution of leishmaniasis in order to provide an adequate management and surveillance.

关键词： Leishmaniasis Epidemiology Argentine Republic Temporal distribution Geographical distribution

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Platelet rich plasma(PRP)induces autophagy in osteoblast precursor 3T3-L1

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BIOCELL 2018年第1期42卷 13-16页

作者： SERGIO ANDRES CARmINATI mARÍA CAROLINA BARBOSA CLAUDIO mARCELO FAdeR universidad nacional de cuyo Facultad de OdontologíaMendozaArgentina Consejo nacional de Investigaciones Científicas y Técnicas(CONICET).Instituto de Histología y Embriología(IHEm) Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendozaArgentina

Autophagy is an essential cellular homeostatic mechanism by which intracellular components are delivered into the lysosomes for degradation and *** has been related with a diversity of pathological or physiological dentary processes such as bone remodeling,skeletal aging,osteoclastogenesis,osteoblastogenesis and different types of oral ***-rich plasma(PRP),isolated from autologous blood,is a plasma preparation containing a higher concentration of platelets which contains numerous different growth factors and cytokines that activate several cellular signaling *** purpose of this study is to investigate the effect of PRP on autophagy stimulation in both osteoblast precursor 3T3-L1 and non-related osteoblastic *** results showed that PRP can increase the number of autophagic structures in 3T3-L1 and HeLa(cervical cancer cells)***,we have determined by Western blot a rise in the lipidated form of the autophagic protein LC3(***3-II)upon PRP *** together,our results suggest that PRP is able to induce a strongly autophagy response in osteoblast precursor and,to a lesser extent,in non-related osteoblastic cells,suggesting that PRP could be a potential therapeutic tool for some autophagy-related diseases associated with bone homeostasis.

关键词： Autophagy 3T3-L1 Platelet rich plasma Odontology

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Adipose-derived mesenchymal stem/stromal cells:from the lab bench to the basic concepts for clinical translation

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BIOCELL 2018年第3期42卷 67-77页

作者： yesica Romina FRONTINI-LóPEZ Aldana Daniela GOJANOVICH Diego mASONE Diego martín BUSTOS marina UHART Laboratorio de Integración de Señles celulares.IHEm-CONICET Universidad Nacional de Cuyo MendozaArgentina facultad de Ingeniería Universidad Nacional de CuyoMendozaArgentina facultad de ciencias Exactas y Naturales Universidad Nacional de CuyoMendozaArgentina

In the last years,much work has shown that the most effective repair system of the body is represented by stem cells,which are defined as undifferentiated precursors that own unlimited or prolonged self-renewal ability,which also have the potential to transform themselves into various cell types through *** tissues that form the body contain many different types of somatic cells,along with stem cells that are called‘mesenchymal stem(or stromal)cells’(mSC).In certain circumstances,some of these mSC migrate to injured tissues to replace dead cells or to undergo differentiation to repair *** discovery of mSC has been an important step in regenerative medicine because of their high ***,the finding of a method to isolate mSC from adipose tissue,so called‘adipose-derived mesenchymal stem cells’(ASC),which share similar differentiation capabilities and isolation yield that is greater than other mSC,and less bioethical concerns compared to embryonic stem cells,have created self-praised publicity to procure almost any treatment with ***,we review the current techniques for isolation,culture and differentiation of human ASC(hASC),and describe them in *** also compile some advantages of the hASC over other stem cells,and provide some concepts that could help finding strategies to promote their therapeutic efficiency.

关键词： hASC Tissue regeneration Cell therapy

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Trypanosoma cruzi invasion in non-phagocytic cells:an ultrastructural study

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BIOCELL 2018年第3期42卷 105-108页

作者： Juan Agustín CUETO Emile SANTOS BARRIAS Wanderley de SOUZA Patricia Silvia ROmANO IHEm Universidad Nacional de CuyoCONICETLaboratorio de Biología de Tripanosoma cruzi y de la célula hospedadoraMendozaArgentina universidad nacional de cuyo.facultad de ciencias médicas.área de biología celular y molecular.mendoza.argentina universidad nacional de cuyo.facultad de ciencias médicas.Instituto de Fisiología.mendoza.argentina Laboratório de Ultraestrutura celular Hertha meyer Instituto de Biofísica Carlos Chagas FilhoCentro de Ciência da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto nacional de Ciência e Tecnologia em biologia Estrutural e Bioimagens e Centro nacional de Bioimagens-CENABIO Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto nacional de metrologia Qualidade e Tecnologia-InmetroRio de JaneiroBrazil

Trypanosoma cruzi is the causative agent of Chagas *** parasite requires the intracellular niche in order to proliferate and disseminate the *** invasion,*** resides temporarily in an acidic vacuole which is lysed by a not well-understood *** electron microscopy was used to describe the process of *** escape from the parasitophorous vacuole over the *** HeLa(non-professional phagocytic cells)as host cell,we observed that recently internalized parasites reside in a membrane-bounded vacuole.A few hours later,the first sign of vacuole disruption appeared as membrane *** observation was followed by a progressive vacuole swelling as evidenced by an electron-lucent halo between the parasite and the vacuole ***,the vacuole membrane remnants reorganized as small vesicles that eventually disappeared from the vicinity of the ***,parasites reach the host cell cytosol where replication takes *** thorough ultrastructural description of this process set the base for a comprehensive understanding of the parasite-host cell interaction and,thus open the possibility of new therapeutic intervention strategies.

关键词： Parasitophorous vacuole Pathogen Parasites Chagas disease Infectious diseases

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