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Benefits of heterospecific aggregation on necromass: in fluence of temperature, group density, and compositi on on fitness-related traits

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Insect Science 2021年第1期28卷 144-152页

作者： Larissa Komo Valery Hedouin Damien Charabidze CHU lille EA 7367—UTML—Unite de Taphonomie Medico-LegaleUniversity of Lille59000 LilleFrance

Necrophagous blowflies(Diptera:Calliphoridae)such as Calliphora vicina,a cold-tolerant species,and L ucilia serie ata,a warm-adapted species,are pioneer carrion・*** these two species have different temperature preferences,larvae aggregate actively and often feed simultaneously on *** hypothesis to be tested was that *** benefits from the association with *** at lower temperatures(i.e.,15℃)and that *** derives greater benefits from this association at higher temperatures(i.e.,28℃).Therefore,both species were raised at these two constant temperatures from first instars to adults under three different conditions:monospecific low-density,monospecific high-density,and heterospecific *** time until larval migration,surface area of puparia,and survival rates were determined for each *** between these fitness-related traits were found between species,temperatures,group densities,and species *** 28°C,*** larvae bred in heterospecific groups migrated significantly earlier and in higher numbers than that under same density conspecific con・ditions,with a lower mortality *** 15°C,both species benefited from high-density heterospecific associations,expressed by faster development and larger *** conclusion,necrophagous larvae benefited from heterospecific aggregations at suboptima 1 temperatures by adapting their migration time to that of the faster *** temperature changes throughout the day and over the year,the beneficiary of such a collective association also *** costs involved and deviations to the temperature-size rule highlight the complexity of the carrion ecosystem.

关键词： carrion ecology development rhythm flies forensic entomology lifehistory traits mutualism

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Neuroendocrine control of natural killer cell function through the checkpoint molecule PD-1

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Cellular & Molecular Immunology 2019年第2期16卷 109-111页

作者： Justine Devulder Anne Tsicopoulos Catherine Duez Pulmonary Immunity Institut National de la SantéEt de la Recherche MédicaleU1019F-59019 LilleFrance Institut Pasteur de lille Center for Infection and Immunity of LilleF-59019 LilleFrance CNRS UMR 8204 F-59000 LilleFrance univ lille Nord de France F-59000 LilleFrance Clinique des Maladies Respiratoires et Centre Hospitalier Régional et universitaire de lille 59037 LilleFrance

Host defense strategies encompass resistance to reduce pathogen burden,and disease tolerance to preserve host fitness.1 Immunedriven resistance mechanisms have inevitably a negative impact on host fitness and can lead to *** tolerance limit immunopathology and therefore disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen *** pathways cooperate to protect the *** pathways include metabolic and oxidative stress responses,2 and the interaction between neuroendocrine system and the immune system3 to favor resolution of inflammation and to prevent tissue damage.

关键词： damage killer inflammation

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Defensins couple dysbiosis to primary immunodeficiency in Crohn's disease

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World Journal of Gastroenterology 2011年第5期17卷 567-571页

作者： Mathias Chamaillard Rodrigue Dessein Institut Pasteur de lille Center for Infection and Immunity of LilleF-59019 LilleFrance Mathias ChamaillardRodrigue DesseinCNRSUMR 8204F-59021 LilleFrance Institut National de la Santé et de la Recherche Médicale U1019Team 7Equipe FRMF-59019 LilleFrance univ lille Nord de France F-59000 LilleFrance C.H.R.U.de lille F-59000 LilleFrance

Antimicrobial peptides,including defensins,are essential effectors in host defence and in the maintenance of immune *** studies have linked the defective expression of both α-and β-defensin to the reduced killing of certain microorganisms by the intestinal mucosa of patients suffering from ileal and colonic Crohn's disease(CD),*** recently have the events leading to defective expression of defensins in CD been further elucidated,and are discussed *** events may account for CD-associated alterations in the microbiome and may subsequently precipitate the development of granulomatous inflammatory lesions in genetically-predisposed *** also address how these discoveries may pave the way for the development of a molecular medicine aimed at restoring gut barrier function in CD.

关键词： Crohn's disease Defensins Primary immuno-deficiencies

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Gate length dependent transport properties of in-plane core-shell nanowires with raised contacts

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Nano Research 2020年第1期13卷 61-66页

作者： Alexandre Bucamp Christophe Coinon David Troadec Sylvie Lepilliet Gilles Patriarche Xavier Wallart Ludovic Desplanque univ.lille CNRSCentrale LilleYncréa ISENUniv.Polytechnique Hauts-de-FranceUMR 8520-IEMNF-59000LilleFrance C2N-UMR 9001 CNRS UniversitéParis-Sud-UniversitéParis-Saclay91120PalaiseauFrance

Three-dimensional(3D)nanoscale crystal shaping has become essential for the precise design of advanced electronic and quantum devices based on electrically gated *** this context,Ⅲ-Ⅴ semiconductor-based nanowires with low electron effective mass and strong spin-orbit coupling are particularly investigated because of their exceptional quantum transport properties and the good electrostatic control they *** the main challenges involved in the processing of these nanodevices are(i)the management of the gate stack which requires ex-situ passivation treatment to reduce the density of traps at the oxide/semiconductor interface,(ii)the ability to get good ohmic contacts for source and drain electrodes and(iii)the scalability and reliability of the process for the fabrication of complex architectures based on nanowire *** this paper,we show that selective area molecular beam epitaxy of in-plane InGaAs/InP core-shell nanowires with raised heavily doped source and drain contacts can address these different *** characterization of the devices down to 4 K reveals the positive impact of the InP shell on the gate electrostatic control and effective electron *** comparable to the best reported values for In(Ga)As nanostructures grown on InP,this latter is severely reduced for sub-100 nm channel highlighting remaining issue to reach the ballistic regime.

关键词： molecular beam epitaxy core-shell nanowire selective area growth effective electron mobility

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Rotating instability in the vaneless diffuser of a radial flow pump

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Journal of Thermal Science 2008年第4期17卷 368-374页

作者： A.Dazin O.Coutier-Delgosha P.Dupont S.Coudert G.Caignaert G.Bois Laboratoire de Mécanique de lille(UMR CNRS 8107) Arts et Métiers ParisTech Laboratoire de Mécanique de lille Ecole Centrale de Lille Laboratoire de Mécanique de lille CNRS

The paper refers to the behavior of a vaneless diffuser of a radial flow pump in partial flow operating conditions. Some experimental data have been obtained using 2D/2C PIV and unsteady pressure measurements within the diffuser, in various operating conditions. The experimental results at the lower flow rate are compared with two-dimensional numerical calculations.

关键词： Vaneless diffuser Radial flow pump Instability Particle Image Velocimetry Pressure measurements 2D calculations.

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Numerical and experimental comparison of the vaned diffuser interaction inside the impeller velocity field of a centrifugal pump

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Science China(Technological Sciences) 2011年第2期54卷 286-294页

作者： ATIF Abdelmadjid BENMANSOUR Saad BOIS Gerard DUPONT Patrick Laboratory of Advanced Mechanics FGMGP/USTHBBP32 El Alia16111AlgerAlgeria Laboratory of Mechanics of lille ENSAM-Lille8 Bd Louis XIV59046LilleFrance Laboratory of Mechanics of lille EC-LilleBP48 Villeneuve d’Ascq59651LilleFrance

The paper refers to the analysis of interactions between the impeller and the vaned diffuser based on the air model of a radial flow *** study deals with a numerical simulation of the flow for a full 360°entire impeller and *** task is carried out closely under the design operating conditions and for one particular position of the impeller blade with respect to the diffuser *** all the results,the focus is mainly on the flow pattern at the exit part inside the impeller facing the diffuser *** results are compared to the available PIV measurements.

关键词： centrifugal pump impeller vaned diffuser rotor-stator interaction

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Experimental study and modeling of hydromechanical behavior of concrete fracture

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Water Science and Engineering 2017年第2期10卷 97-106页

作者： He Yang Shou-yi Xie Jean Secq Jian-fu Shao Laboratory of Mechanics of lille University of Lille Villeneuve d'Ascq 59655 France

In this study, the hydromechanical behavior of a concrete fracture under coupled compressive and shear stresses was investigated. A special experimental device was designed to create a planar fracture in a cylindrical sample and to carry out different kinds of hydromechanical tests on the fracture. Four series of laboratory tests were performed on an ordinary concrete sample. Hydrostatic compression tests were first conducted to characterize the normal compressibility of the fracture. In the second series, direct shear tests were conducted on the fracture under different normal stresses. The maximal shear stress of the fracture was determined as a function of the normal stress. In the third series, fluid flow tests were carried out in view of characterizing the overall hydraulic conductivity of the fracture as a function of its opening and closure. Shear tests with a constant fluid pressure were finally performed to investigate the influence of fluid pressure on the deformation behavior of concrete fractures. Based on the experimental investigation, an elastoplastic model is proposed. This model takes into account the nonlinear elastic behavior of a fracture under normal compression and the plastic deformation and failure due to shear stress. The model was coupled with the classical Darcy's law to describe the fluid flow along the fracture by considering the variation of permeability with fracture aperture. Numerical results agree with experimental data from various laboratory tests.

关键词： Concrete fracture Direct shear Hydromechanical coupling Hydraulic conductivity Elastoplastic model

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Norine: A powerful resource for novel nonribosomal peptide discovery

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Synthetic and Systems Biotechnology 2016年第2期1卷 89-94页

作者： M.Pupin Q.Esmaeel A.Flissi Y.Dufresne P.Jacques V.Leclère univ lille CNRSCentrale LilleUMR 9189-CRIStAL-Centre de Recherche en Informatique Signal et Automatique de LilleF-59000 LilleFrance Inria-lille Nord Europe Villeneuve d’Ascq Cedex F-59655France univ lille INRAISAUniv ArtoisUniv Littoral Coce d’OpaleEA 7394-ICV-Institut Charles ViolletteF-59000 LilleFrance Bioindustry Unit Gembloux Agro-Bio Tech-University of LiegePassage des Déportés2Gembloux 5030Belgium

Since its first release in 2008,Norine remains the unique resource completely devoted to nonribosomal peptides(NRPs).They are very attractive microbial secondary metabolites,displaying a remarkable diversity of structure and ***(http://***/NRP)includes a database now containing more than 1160 annotated peptides and user-friendly interfaces enabling the querying of the database,through the annotations or the structure of the *** tools are associated for structural comparison of the compounds and prediction of their biological *** this paper,we start by describing the knowledgebase and the dedicated *** then present some user cases to show how useful Norine is for the discovery of novel nonribosomal peptides.

关键词： Norine Nonribosomal peptides Secondary metabolites Database

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Saccharomyces cerevisiae prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats

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World Journal of Gastroenterology 2023年第5期29卷 851-866页

作者： Caroline Valibouze Silvia Speca Caroline Dubuquoy Florian Mourey Lena M'Ba Lucil Schneider Marie Titecat Benoît Foligné Michaël Genin Christel Neut Philippe Zerbib Pierre Desreumaux Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France U1286-INFINITE-Institute for Translational Research in Inflammation Univ.LilleInsermCHU LilleLille 59000France Intestinal Biotech Development Lille 59045France Department of Research and Applications Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France ULR 2694-METRICS:Évaluation des Technologies de Santéet des Pratiques Médicales University of LilleLille University HospitalLille 59000France Department of Hepato-Gastroenterology Lille University HospitalLille 59037France

BACKGROUND Postoperative recurrence(POR)after ileocecal resection(ICR)affects most Crohn's disease patients within 3-5 years after ***-invasive Escherichia coli(AIEC)typified by the LF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease *** cerevisiae CNCM I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elimination from the *** To evaluate the efficacy of CNCM I-3856 in preventing POR induced by LF82 in an HLA-B27 transgenic(TgB27)rat *** Sixty-four rats[strain F344,38 TgB27,26 control non-Tg(nTg)]underwent an ICR at the 12th wk(W12)of life and were sacrificed at the 18th wk(W18)of ***27 rats were challenged daily with oral administration of LF82(109 colony forming units(CFUs)/day(d),n=8),PBS(n=5),CNCM I-3856(109 CFUs/d,n=7)or a combination of LF82 and CNCM I-3856(n=18).nTg rats receiving LF82(n=5),PBS(n=5),CNCM I-3856(n=7)or CNCM I-3856 and LF82(n=9)under the same conditions were used as *** was analyzed using macroscopic(from 0 to 4)and histologic(from 0 to 6)*** LF82 quantifications were performed weekly for each *** LF82 and inflammatory/regulatory cytokines were quantified in biopsies at W12 and *** are expressed as the median with the interquartile *** nTg animals did not develop POR.A total of 7/8(87%)of the TgB27 rats receiving LF82 alone had POR(macroscopic score≥2),which was significantly prevented by CNCM I-3856 administration[6/18(33%)TgB27 rats,P=0.01].Macroscopic lesions were located 2 cm above the anastomosis in the TgB27 rats receiving LF82 alone and consisted of ulcerations with a score of 3.5(2-4).Seven out of 18 TgB27 rats(39%)receiving CNCM I-3856 and LF82 had no macroscopic *** to untreated TgB27 animals receiving LF82 alone,coadministration of CNCM I-3856 and LF82 significantly red

关键词： Crohn's disease Recurrence Escherichia coli Probiotic Saccharomyces cerevisiae Colorectal surgery

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Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia:testicular sperm extraction outcomes

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Asian Journal of Andrology 2019年第5期21卷 445-451页

作者： Anne-Laure Barbotin Anais Dauvergne Agathe Dumont Nassima Ramdane Valerie Mitchell Jean-Marc Rigot Florence Boitrelle Geoffroy Robin CHU lille Reproductive Biology-Spermiology-CECOS InstituteJeanne de Fla nd re HospitalF-59000 LilleFrance EA4308:Gametogenesis and Gamete Quality Lille UniversityF-59000 LilleFrance CHU lille Department of AndrologyCalmette HospitalF-59000 LilleFrance CHU lille Department of Endocrine Gynaecology and Reproductive MedicineJeanne de Flandre HospitalF-59000 LilleFrance CHU lille Department of BiostatisticsEA2694Lille UniversityF-59000 LilleFrance Fertility Unit Poissy-Saint-Germain-en-Laye General Hospital78303 PoissyFrance.

Cryptorchidism is one of the most frequent causes of nonobstructive azoospermia(NOA)in *** it is well known that spermatogenesis is more impaired in bilateral than in unilateral cryptorchidism,previous studies have only described small cohorts or inhomogeneous ***,we analyzed a cohort of 225 men with only a history of cryptorchidism as sole etiopathogenetic factor for NOA,and compared testicular sperm extraction(TESE)outcomes between men with bilateral versus unilateral *** results show no difference in follicle-stimulating hormone(FSH)levels and testicular volumes between men with a history of bilateral cryptorchidism compared to unilateral cryptorchidism(median:21.3 IU I^-1 vs 19.3 IU I^-1,P=0.306;and 7.2 ml vs 7.9 ml,P=0.543,respectively).In addition,sperm retrieval rates were similar(66.2%vs 60.0%,P=0.353).Using multivariate analysis,we have found that only a low inhibin B level(above the assay's detection limit)was positively associated with successful sperm retrieval(P<0.05).Regarding intracytoplasmic sperm injection outcomes,we found that cumulative pregnancy rate and live birth rate per cycle were not statistically different between the two groups(17.4%vs 27.8%,P=0.070;and 16.1%vs 26.4%,P=0.067,respectively).Unexpectedly,there was no significant difference in hormonal profiles(FSH,luteinizing hormone[LH],testosterone,and inhibin B levels)and TESE outcomes between unilateral versus bilateral *** suggests that a history of unilateral cryptorchidism could reflect a bilateral testicular ***,inhibin B level might be a predictor of successful TESE.

关键词： cryptorchidism in tracytoplasmic sperm in jection non obstructive azoospermia testicular sperm extraction

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