Defensins couple dysbiosis to primary immunodeficiency in Crohn's disease

作     者：Mathias Chamaillard Rodrigue Dessein 

作者机构：Institut Pasteur de LilleCenter for Infection and Immunity of LilleF-59019 LilleFrance Mathias ChamaillardRodrigue DesseinCNRSUMR 8204F-59021 LilleFrance Institut National de la Santé et de la Recherche MédicaleU1019Team 7Equipe FRMF-59019 LilleFrance Univ Lille Nord de FranceF-59000 LilleFrance C.H.R.U.de LilleF-59000 LilleFrance 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第5期

页      面：567-571页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：免疫缺陷 防御素 TiAl基 宿主防御 肠道黏膜 分子医学 屏障功能 微生物 

摘      要：Antimicrobial peptides,including defensins,are essential effectors in host defence and in the maintenance of immune homeostasis.Clinical studies have linked the defective expression of both α-and β-defensin to the reduced killing of certain microorganisms by the intestinal mucosa of patients suffering from ileal and colonic Crohn s disease(CD),respectively.Only recently have the events leading to defective expression of defensins in CD been further elucidated,and are discussed herein.These events may account for CD-associated alterations in the microbiome and may subsequently precipitate the development of granulomatous inflammatory lesions in genetically-predisposed patients.We also address how these discoveries may pave the way for the development of a molecular medicine aimed at restoring gut barrier function in CD.