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Central role of myeloid MCPIP1 in protecting against LPSinduced inflammation and lung injury

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Signal Transduction and Targeted Therapy 2017年第1期2卷 18-32页

作者： Yong Li Xuan Huang Shengping Huang Hui He Tianhua Lei Fatma Saaoud Xiao-Qiang Yu Ari Melnick Anil Kumar Christopher J Papasian Daping Fan Mingui Fu Department of Biomedical Science and Shock/trauma Research Center School of MedicineUniversity of Missouri-Kansas CityKansas CityMissouriMOUSA Institute of Translational Medicine Nanchang UniversityNanchangJiangxiP.R.China Department of Cell Biology and Anatomy University of South Carolina School of MedicineColumbiaSCUSA Division of Molecular Biology and Biochemistry School of Biological SciencesUniversity of Missouri-Kansas CityKansas CityMissouriMOUSA Division of Hematology and Medical Oncology Weill Cornell Medical CollegeNew YorkNYUSA Division of Pharmacology and Toxicology School of PharmacyUniversity of Missouri-Kansas CityKansas CityMissouriMOUSA

Although systemic inflammatory responses attributable to infection may lead to significant lung injury,the precise molecular mechanisms leading to lung damage are poorly understood and therapeutic options remain ***,we show that myeloid monocyte chemotactic protein-inducible protein 1(MCPIP1)plays a central role in protecting against LPS-induced inflammation and lung ***-specific MCPIP1 knockout mice developed spontaneous inflammatory syndromes,but at a late age compared to global MCPIP1 knockout ***,mice with a myeloid-specific deletion of MCPIP1 were extremely sensitive to LPS-induced lung injury due to overproduction of proinflammatory cytokines and *** identified C/EBPβand C/EBPδ,two critical transcriptional factors that drive cytokine production and lung injury,as targets of MCPIP1 *** administration caused MCPIP1 protein degradation in the *** inhibition of MALT1,a paracaspase that cleaves MCPIP1,by MI-2 selectively increased the MCPIP1 protein levels in macrophages and in the ***,administration of MI-2 protected mice from LPS-induced inflammation,lung injury and ***,these results indicate that myeloid MCPIP1 is central in controlling LPS-induced inflammation and lung *** inhibition of MALT1 protease activity may be a good strategy to treat inflammatory diseases by enhancing MCPIP1 expression in myeloid cells.

关键词： inflammation myeloid lung

Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive Materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo Pan Paul K.Chu Kenneth M.C.Cheung Kelvin W.K.Yeung Department of Orthopaedics and traumatology The University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of Materials Science and Engineering Nankai UniversityTianjinChina School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite Magnesium ion Microenvironment 3D scaffold Bone tissue regeneration

Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization

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Burns & trauma 2021年第1期9卷 299-310页

作者： Zengjun Yang Xiaohong Hu Lina Zhou Yaxiong He Xiaorong Zhang Jiacai Yang Zhenyu Ju Yih-Cherng Liou Han-Ming Shen Gaoxing Luo Michael R.Hamblin Weifeng He Rui Yin Department of Dermatology Southwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China State Key Laboratory of trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Chongqing Key Laboratory for Disease Proteomics No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Department of Endocrinology Southwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityNo.601 Huangpu StreetTianhe DistrictGuangzhouGuangdong Province510632China Department of Biological Sciences National University of Singapore14 Science Drive 4117543Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of Singapore14 Science Drive 4117543Singapore Wellman Center for Photomedicine Massachusetts General HospitalHarvard Medical School40 Blossom StreetBostonMA02114USA Laser Research Centre Faculty of Health ScienceUniversity of JohannesburgDoornfontein 202817011 South Africa

Background:Epidermal stem cells(EpSCs)that reside in cutaneous hair follicles and the basal layer of the epidermis are indispensable for wound healing and skin *** is known about the effects of photochemical activation on EpSC differentiation,proliferation and migration during wound *** present study aimed to determine the effects of photodynamic therapy(PDT)on wound healing in vivo and in ***:We created mouse full-thickness skin resection models and applied 5-aminolevulinic acid(ALA)for PDT to the wound *** healing was analysed by gross evaluation and haematoxylin–eosin staining in *** cultured EpSCs,protein expression was measured using flow cytometry and *** migration was examined using a scratch model;apoptosis and differentiation were measured using flow ***:PDT accelerated wound closure by enhancing EpSC differentiation,proliferation and migration,thereby promoting re-epithelialization and *** inhibited inflammatory infiltration and expression of proinflammatory cytokines,whereas the secretion of growth factors was greater than in other *** proportion of transient amplifying cells was significantly greater in vivo and in vitro in the PDT *** migration was markedly enhanced after ALAinduced ***:Topical ALA-induced PDT stimulates wound healing by enhancing re-epithelialization,promoting angiogenesis as well as modulating skin *** work provides a preliminary theoretical foundation for the clinical administration of topical ALA-induced PDT in skin wound healing.

关键词： Photodynamic therapy wound healing 5-aminolevulinic acid Re-epithelialization Epidermal stem cells Transient amplifying cells

创伤CT在创伤室与影像科的成本效能的对比效应试验

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国际医学放射学杂志 2013年第2期 186-186页

作者： T.P. Saltzherr J.C. Goslings F.C. Bakker L.F.M. Beenen M. Olff K. Meijssen 赵芳 trauma Unit Department of Surgery Academic Medical Center Meibergdreef 91105 AZ Amsterdam the Netherlands

目的确定创伤室CT与影像科CT的成本效能。方法随机对照研究纳入需在一楼创伤中心检查的成人病人。介入组所在医院,CT设备放置于创伤室,而对照组所在医院将CT设备置于影像科。计算程序化的住院,诊断,疗程的直接、间接医疗成本。结果根据... 详细信息

目的确定创伤室CT与影像科CT的成本效能。方法随机对照研究纳入需在一楼创伤中心检查的成人病人。介入组所在医院,CT设备放置于创伤室,而对照组所在医院将CT设备置于影像科。计算程序化的住院,诊断,疗程的直接、间接医疗成本。结果根据有可比性的人口特征,对1124例病人进行随机分组。介入组的非程序化住院时间平均为322.5d(95%CI:314～331d),对照组为320.7d(95%CI:312.1～329.2d)。介入组与对照组住院每天的平均诊疗成本分别为554和468欧元。介入组与对照组平均总成本分别为16002欧元(95%CI:13075～18929欧元)和16635欧元(95%CI:13528～19743欧元)(P=0.77)。结论研究显示,对于给创伤病人带来健康经济成本方案方面,CT设备放置于创伤室并不比放置于影像科有明显的优势或不足。要点①CT检查对于创伤病人越来越重要。②急诊科可以设有CT设备或使用影像科的CT设备。③CT成本效能不受CT放置场所的影响。④CT放置的场所不影响非程序化住院存活时间。⑤CT放置的最佳场所需进一步评估。

关键词：创伤 CT 成本效能创伤室 RCT

Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation

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Bioactive Materials 2022年第3期7卷 491-507页

作者： Yijun He Wenhao Wang Shaozhang Lin Yixi Yang Lizhi Song Yihan Jing Lihao Chen Zaopeng He Wei Li Ao Xiong Kelvin W.K.Yeung Qi Zhao Yuan Jiang Zijie Li Guoxian Pei Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Hand and Foot Surgery&Plastic Surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityFoshan528315PR China Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhen518036PR China National&Local Joint Engineering Research Center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen518036PR China Department of Orthopaedics and traumatology The University of Hong KongPokfulamHong Kong999077PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China The Third Affiliated Hospital of Southern University of Science and Technology Southern University of Science and TechnologyShenzhen518055PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Medical Technology and Related Equipment Research for Spinal Injury Treatment City Key LaboratoryThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China

The potential translation of bio-inert polymer scaffolds as bone substitutes is limited by the lack of neovascularization upon implantation and subsequently diminished ingrowth of host bone,most likely resulted from the inability to replicate appropriate endogenous crosstalk between *** umbilical vein endothelial cell-derived decellularized extracellular matrix(HdECM),which contains a collection of angiocrine biomolecules,has recently been demonstrated to mediate endothelial cells(ECs)-osteoprogenitors(OPs)*** employed the HdECM to create a PCL(polycaprolactone)/fibrin/HdECM(PFE)hybrid *** hypothesized PFE scaffold could reconstitute a bio-instructive microenvironment that reintroduces the crosstalk,resulting in vascularized bone *** implantation in a rat femoral bone defect,the PFE scaffold demonstrated early vascular infiltration and enhanced bone regeneration by microangiography(μ-AG)and micro-computational tomography(μ-CT).Based on the immunofluorescence studies,PFE mediated the endogenous angiogenesis and osteogenesis with a substantial number of type H vessels and *** addition,superior osseointegration was observed by a direct host bone-PCL interface,which was likely attributed to the formation of type H *** bio-instructive microenvironment created by our innovative PFE scaffold made possible superior osseointegration and type H vessel-related bone *** could become an alternative solution of improving the osseointegration of bone substitutes with the help of induced type H vessels,which could compensate for the inherent biological inertness of synthetic polymers.

关键词： Cell-derived decellularized extracellular matrix Microenvironment Vascularized bone regeneration Type H vessels Osseointegration

Orbital Floor Fractures: Epidemiological, Clinical and Therapeutical Study at Sylvanus Olympio University Teaching Hospital in Loméabout 51 Cases

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Open Journal of Stomatology 2021年第9期11卷 373-386页

作者： Saliou Adam Hamza Dolès Sama Yao Messanvi Akpoto Haréfétéguéna Bissa Palakina Agoda Winga Foma Essobozou Plaoudézina Pegbessou Bathokédéou Amana Essohanam Boko Eyawèlohn Kpemissi Department of Stomatology and Maxillofacial Surgery Sylvanus Olympio University Teaching Hospital of Lomé Togo Department of ENT Sylvanus Olympio University Teaching Hospital of Lomé Togo Department of Anesthesia and Intensive care Sylvanus Olympio University Togo Military Medical Department Sylvanus Olympio University Teaching Hospital of Lomé Togo Department of Stomatology Campus University Teaching Hospital of Lomé Togo Department of ENT Campus University Teaching Hospital of Lomé Togo

Introduction: Orbital floor fractures are a significant pathology among maxillofacial injuries. They can cause oculomotor, sensory, and sometimes esthetic disorders. The goal of this study was to determine the epidemiological profile of orbital floor fractures and show their clinical and therapeutic approach in Lomé. Patients and method: This was a descriptive retrospective study of orbital floor fractures collected in the ENT and maxillofacial surgery department of Sylvanus Olympio University Hospital in Lomé over 8 years (January 1, 2011 to December 31, 2018). Results: We reviewed 63 cases of orbital floor fractures out of 552 cases of facial trauma. According to the inclusion and non-inclusion criteria, we retained 51 cases. The hospital frequency of orbital floor fractures was 9.24% of facial fractures. The average age of the patients was 35 ± 10.34 years. Males were predominant (ratio = 7.5). The main etiology was road accidents (92.16%). Ophthalmological signs were dominated by vertical diplopia (31.37%), limited eye movement (25.49%), and enophthalmia (29.41%). The sensory sign was dominated by suborbital hypoesthesia (13.73%). Surgical treatment was performed in 86.27% of patients. The average intervention time was 17.84 ± 12.69 days after the trauma. The main approach was the subciliary route (65.91%). The surgical procedures consisted of muscle and fat removal (20.45%) and orbital floor repair by mesh plate (50%). The average length of hospitalization was 9.63 ± 5.23 days. Surgical site infection was the main postoperative complication observed in 3.92% of patients. The main sequelae were diplopia (4.55%), suborbital hypoesthesia (4.55%), and enophthalmos (4.55%). Conclusion: Orbital floor fractures are mainly due to road accidents. Management must be multidisciplinary and adequate in order to avoid irreversible functional and/or morphological sequelae. Their prevention consists of effecti

关键词： Orbital Floor Fracture Diplopia Facial Bone Road Accidents Lomé (Togo)

Can we predict which patients with community-acquired pneumonia are likely to have positive blood cultures？

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World Journal of Emergency Medicine 2011年第4期2卷 272-278页

作者： Samuel George Campbell R. Andrew McIvor Vincent Joanis David Graydon Urquhar Department of Emergency Medicine Charles V Keating Emergency and Trauma Centre 1796 Summer St Halifax NovaScotia B3H3A7 Canada (Campbell SG Urquhart DG) T2127 Firestone Institute for Respiratory Health St. Joseph′sHealth Care Hamilton Hamilton ON. L8N 4A6 Canada (McIvor RA) Foothills Medical Centre 1403 - 29th Street N.W.University of Calgary Calgary Alberta Canada (Joanis V)

BACKGROUND： Blood cultures （BC ） are commonly ordered during the initial assessment ofpatients with community-acquired pneumonia （CAP）, yet their yield remains low. Selective use of BCwould allow the opportunity to save healthcare resources and avoid patient discomfort. The studywas to determine what demographic and clinical factors predict a greater likelihood of a positiveblood culture result in patients diagnosed with ***： A structured retrospective systematic chart audit was performed to comparerelevant demographic and clinical details of patients admitted with CAP, in whom blood culture resultswere positive, with those of age, sex, and date-matched control patients in whom blood cultureresults were ***： On univariate analysis, eight variables were associated with a positive BC *** logistic regression analysis, however, the only variables statistically significantly associatedwith a positive BC were WBC less than 4.5 x 109/L [likelihood ratio （LR）： 7.75, 95% CI=2.89-30.39], creatinine 〉106 !mol/L （LR： 3.15, 95%CI=1.71-5.80）, serum glucose〈6.1 mmol/L （LR： 2.46,95%CI=1.14-5.32）, and temperature 〉 38 °C （LR： 2.25, 95% CI =1.21-4.20）. A patient with all of thesevariables had a LR of having a positive BC of 135.53 （95% CI=25.28-726.8） compared to patientswith none of these ***： Certain clinical variables in patients with CAP admitted to hospitals doappear to be associated with a higher probability of a positive yield of BC, with combinations of thesevariables increasing this likelihood. We have identified a subgroup of CAP patients in whom bloodcultures are more likely to be useful.

关键词： Community-acquired pneumonia Blood cultures

股骨颈疝窝的CT评价:患病率、特征及其与股骨髋臼撞击综合征的形态学危险因素之间的可能关系

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国际医学放射学杂志 2008年第A6期31卷 512-512页

作者： S.Panzer P.Augat U.Esch 段小慧 Department of Radiology Trauma Center Murnau Prof.-Kntscher-Strasse 8 82418 Murnau Germany.

本研究的目的是评价CT上出现股骨颈疝窝(her-niation pits,HPs)与凸轮型及钳型股骨髋臼撞击综合征(femoroacetabular impingement,FAI)

关键词：螺旋CT 髋关节股骨颈骨性关节炎

Corrigendum to“Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway”[***.5(2020)334-347]

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Bioactive Materials 2021年第8期6卷 2643-2645页

作者： Xu Cui Yadong Zhang Jianyun Wang Chengcheng Huang Yudong Wang Hongsheng Yang Wenlong Liu Ting Wang Deping Wang Guocheng Wang Changshun Ruan Dafu Chen William W.Lu Wenhai Huang Mohamed N.Rahaman Haobo Pan Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055PR China Schools of Materials Science and Engineering Tongji UniversityShanghai201804PR China Department of Orthopaedics Shanghai Fengxian Central HospitalSouth Campus of the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai201499PR China Department of Orthopaedics Fengxian Central Hospital Affiliated to Southern Medical UniversityShanghai201499PR China Shenzhen Healthemes Biotechnology Co.Ltd Shenzhen518102PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic trauma Department of OrthopaedicsThe University of Hong Kong-Shenzhen HospitalUniversity of Hong KongShenzhen518053PR China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing100035PR China Department of Orthopaedics and traumatology The University of Hong KongRoom 907Lab Block21 Sassoon RoadHong KongChina Department of Materials Science and Engineering Missouri University of Science and TechnologyMO65409-0340USA

The authors regret that the printed version of the above article contained a number of errors which were not identified during the proofing *** correct and final version *** authors would like to apologies for any inconvenience *** authors regret:1.“…and the underlying molecular mechanism of this simulation is yet to be determined”,Page 335,needs to be corrected to“and the underlying molecular mechanism of this stimulation is yet to be determined”.

关键词： silicate corrected stimulation