Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

作     者：Jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo Pan Paul K.Chu Kenneth M.C.Cheung Kelvin W.K.Yeung 

作者机构：Department of Orthopaedics and TraumatologyThe University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic TraumaDepartment of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and OrthopaedicsShanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of Materials Science and EngineeringNankai UniversityTianjinChina School of Materials Science&Engineeringthe Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsHubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Cixi Center of Biomaterials Surface EngineeringShanghai Institute of CeramicsChinese Academy of SciencesNingboChina Center for Human Tissues and Organs DegenerationShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of PhysicsDepartment of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第2期

页      面：503-519页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：This work was financially supported by the National key R&D Program of China(2018YFC1105100) Health and Medical Research Fund(19180712) Shenzhen Science and Technology Funds(JSGG20180507183242702) Hong Kong Innovation Technology Fund(ITS/287/17 and ITS/405/18) Hong Kong Research Grant Council General Research Fund(17214516) the Science and Technology Commission of Shanghai Municipality(18410760600) International Partnership Program of Chinese Academy of Sciences(GJHZ1850) National Natural Science Foundation of China(81572113) 

主　　题：Nanocomposite Magnesium ion Microenvironment 3D scaffold Bone tissue regeneration 

摘      要：The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.