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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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Thermally activated delayed fluorescence enhanced by macrocyclization

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Science China Chemistry 2025年

作者： Shuo Li Chenghao Zhu Lijun Mao Xin Zhang Zecong Ye Chunju Li Da Ma School of Pharmaceutical and Chemical Engineering & Institute for Advanced studies Taizhou University School of Chemical Engineering and Light Industry Guangdong University of Technology tianjin Key Laboratory of Structure and Performance for Functional Molecules Tianjin Normal University

Thermally activated delayed fluorescence (TADF) depends on reverse intersystem crossing (RISC) from the lowest triplet to the singlet excited state. Here, a macrocyclization strategy is developed to achieve TADF emission by promoting RISC. 5-(9Hcarbazol-9-yl) isophthalonitrile, a fluorescent molecule, is coupled with 1,4-dimethoxybenzene by methylene bridges to form a macrocycle with TADF emission. Experimental results and theoretical calculation indicate that the macrocyclization strategy contributes to RISC promotion and suppression of nonradiative decay, resulting in effective TADF emission transformed from prompt fluorescence. Three TADF luminophores are cyclized with the same strategy, and an enhanced TADF emission of up to3.8 folds is observed. The marriage of macrocycle chemistry and luminescent materials will provide new guidelines for designing efficient TADF materials.

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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of tianjin univ.rsity of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong univ.rsity NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Realization of Interpersonal Function of Euphemism from Perspective of Fuzzy Linguistics

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学术界 2015年第8期 288-293页

作者： Feng Donglin Department of College foreign Languages studies tianjin univ.rsity of Commerce Tianjin 300134

Euphemisms are widely employed in every aspect of social life. The analysis is made on the realization of interpersonal function of euphemism as a fuzzy language on the basis of discussion on the relationship between euphemism and fuzzy linguistics. It is hoped that the analysis can enrich and perfect the current research on euphemism so that the readers can have a general picture of euphemism and employ euphemisms more precisely and properly in communication. By so doing,the communication can be smoother and the objective of communication can be better achieved.

关键词：语言学模糊社会生活通信

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Contour representation based on wedgelet

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Journal of Systems Engineering and Electronics 2006年第2期17卷 251-257页

作者： Liu Zeyi~1, Sun Ziqiang~ 2,3 , Xu Ling~2 & Peng Xiang~ 4,5 1. Dept. of Mathematics of Science Coll., Shenzhen univ., Shenzhen 518060, P.R. China 2. Dept. of Mathematics of Science Coll., tianjin univ., tianjin 300072, P.R. Ch ina 3.tianjin foreign studies univ., tianjin 300204, P.R. China 4. Inst. of Optoelectronics, Shenzhen univ., Shenzhen 518060, P.R. China 5. National Lab of Precision Measurement Technology and Instrumentation, tianjin 300072, P.R. China Dept. of Mathematics of Science Coll. Shenzhen Univ. Shenzhen 518060 P. R. China Dept. of Mathematics of Science Coll. Tianjin Univ. Tianjin 300072 P. R. China tianjin foreign studies univ. Tianjin 300204 P. R. China Inst. of Optoelectronics Shenzhen Univ. Shenzhen 518060 P. R. China National Lab of Precision Measurement Technology and Instrumentation Tianjin 300072 P. R. China

Aiming at the shortcomings of the existing wedgelet compression arithmetics, a novel contour-representing algorithm based on wedgelets is presented in this paper. Firstly the input image is binarized and the most optimized wedgelets are found by means of quadtree framework. Then the contours are reconstructed by applying the wedgelets, the data volume is compressed, and the shortcomings of the contour representation based on normal wavelet are ameliorated, the better effect for the visualization is obtained, too.

关键词： wedgelet binarization quadtree.

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Light Emitting Diode Based on Tb(AcAc)_(3)Phen

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Chinese Physics Letters 1997年第1期14卷 71-73页

作者： CHEN Li-chun WANG Xiang-jun ZHANG Ruo-hua DENG Zhen-bo YAO Jian-quan Jennifer Carter Institute of Laser and Photonics Tianjin UniversityTianjin 300072 Institute of Material Physics Tianjin Institute of TechnologyTianjin 300191 Departmetn of Chemistry Nankai UniversityTianjin 300071 Department of Physics Fudan UniversityShanghai 200433 Department of foreign studies Tianjin Institute of TechnologyTianjin 300191

A diode with Tb(AcAc)_(3)Phen as the emitting layer and PPV,Alq_(3) as the hole and electron transporting layers was *** emission of the diode had the unique line spectrum of pure Tb^(3+).The injected electron and hol... 详细信息

关键词： Phen pure spectrum

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A Creative Computing Approach to Film-story Creation:A Proposed Theoretical Framework

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International Journal of Automation and computing 2020年第5期17卷 678-690页

作者： Hong-Wei Liu Hong-Rui Liu Hong-Ji Yang En-Ze Yu tianjin foreign studies univ.rsity Tianjin 300204China San Jose State univ.rsity San Jose 95192USA univ.rsity of Leicester Leicester LE17RHEngland South China Business College Guangdong University of Foreign StudiesGuangzhou 510545China

The film industry is currently witnessing a severe shortage of good stories and a decline in storytelling ***,creative computing has been employed successfully in the humanities,especially in the fields of *** the similarities between the process of film-story creation and that of creative computing,we propose a theoretical framework across the two domains,where the exploratory,the combinational and the transformational rules are jointly utilized to generate new ideas and provide potential options in film-story *** framework consists of a film knowledge library,a creative computing system,an evaluation model and an output *** combination of creative computing and film story creation not only helps to produce novel storylines,shorten the creation cycle,and speed up film industry,but also contributes to the novelty and specificity of interdisciplinary studies.

关键词： Creative computing film-story creation creativity rules automatic generation human-like scriptwriting

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On the Construction of Knowledge Ecology Models in the Strategic Change from Traditional Enterprises to Innovative Enterprises from the Perspective of Combination Innovation

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学术界 2015年第7期 282-286页

作者： Liu Yan Li Yuntao International School of Commerce tianjin foreign studies univ.rsity Tianjin 300204 School of Commerce tianjin univ.rsity of Commerce Tianjin 300134

The paper expounds the extensive ecological process of knowledge creation in the strategic change from traditional enterprises to innovative enterprises from the perspective of integrating innovation,analyzes the systematic integration process of the three links including knowledge preparation,knowledge production and knowledge diffusion in the two different change paths of integrated innovation and digestive absorption innovation,and establishes the knowledge ecology models in different paths.

关键词：传统企业知识创造创新型生态模式生态学模型生态过程集成过程知识扩散

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Optimization of CZTSSe thin film solar cell performance using PbS back surface field layer

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Optoelectronics Letters 2025年

作者： WENJING LUO ZHIJIAN BAI YUMING XUE LUOXIN WANG YANHONG DING HONGLI DAI tianjin Key Laboratory of Film Electronic & Communication Devices， School of Electronics Information Engineering， tianjin univ.rsity of Technology School of Materials Science and Engineering ，Jilin univ.rsity

CZTSSe is an Earth-abundant， environmentally friendly， and low-cost material， with a current record power conversion efficiency of 14.9%， This result is well below the prediction of the Shockley-Queisser limit. To improve the performance of solar cells， a layer of PbS (BSF) was added to the CZTSSe， which was simulated using the SCAPS-1D software. The optimal photovoltaic performance of AZO/ZnO/CdS/CZTSSe/PbS/Mo was studied by changing the parameters of the CZTSSe absorption layer and PbS layer. studies have shown that the efficiency can be increased to 20.86% after using PbS.

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