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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research center of stem cells Translational Medicine ShanghaiChina National center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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Progress of clinical therapies for dry age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 157-166页

作者： Rhianna Rubner Kang V.Li M.Valeria Canto-Soler cellSight Ocular stem cell and Regeneration Research Program Department of OphthalmologySue Anschutz-Rodgers Eye CenterUniversity of Colorado School of MedicineAuroraCO 80045USA

Dry age-related macular degeneration(AMD)is a progressive blinding disease that currently affects millions of people worldwide with no successful treatment *** research efforts are currently underway to develop therapies aimed at slowing the progression of this disease or,more notably,reversing *** the therapies which have reached clinical trial for treatment of dry AMD were reviewed.A thorough search of Pub Med,Embase,and *** has led to a comprehensive collection of the most recent strategies being *** review also endeavors to assess the status and future directions of therapeutics for this debilitating condition.

关键词： dry age-related macular degeneration age-related macular degeneration drug therapy

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Correction to:Efficient derivation of extended pluripotent stem cells from NOD-scid II2rg^-/-mice

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Protein & cell 2019年第1期10卷 154-155页

作者： Yaqin Du Ting Wang Jun Xu Chaoran Zhao Haibo Li Yao Fu Yaxing Xu Liangfu Xie Jingru Zhao Weifeng Yang Ming Yin Jinhua Wen Hongkui Deng Peking University stem cell Research center Department of Cell BiologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program College of Life SciencesPeking UniversityBeijing 100871China The MOE Key Laboratory of cell Proliferation and Differentiation College of Life SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Beijing Vitalstar Biotechnology Beijing 100012China

Figure *** of NOD-scid II2rg^-1-extended pluripotent stem cells.(A)Schematic of two approaches used for generating NOD-scid II2rg^-1-extended pluripotent stem cells:de novo derivation from blastocysts(upper panels)and chemical reprogramming from embryonic fibroblasts(lower panels).(B)Phase-contrast images of de novo derived outgrowth and EPS colonies for 17 passages in LCDM *** bars,100 pm.(C)qRT-PCR analysis of XEN marker genes expression during the chemical induction process(day 16).Error bars indicate SEM(n=2).(D)Co-immunostaining of XEN marker genes during the chemical induction process(day 16).Upper panels:GATA6 and SALL4;lower panels:SOX17 and *** bars,100 pm.

关键词： Generation LCDM Error

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Understanding the“SMART”features of hematopoietic stem cells and beyond

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Science China(Life Sciences) 2021年第12期64卷 2030-2044页

作者： Shiru Yuan Guohuan Sun Yawen Zhang Fang Dong Hui Cheng Tao Cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China center for stem cell Medicine Chinese Academy of Medical SciencesTianjin 300020China department of stem cell&Regenerative Medicine Peking Union Medical CollegeTianjin 300020China

Since the huge success of bone marrow transplantation technology in clinical practice,hematopoietic stem cells(HSCs)have become the gold standard for defining the properties of adult stem cells(ASCs).Here,we describe the“self-renewal,multilineage differentiation,apoptosis,rest,and trafficking”or“SMART”model,which has been developed based on data derived from studies of HSCs as the most well-characterized stem cell *** the potential therapeutic applications of ASCs,we delineate the key characteristics of HSCs using this model and speculate on the physiological relevance of stem cells identified in other *** strides are being made in understanding the biology of ASCs,and efforts are now underway to develop safe and effective ASC-based therapies in this emerging area.

关键词： stem cell biology adult stem cells hematopoietic stem cells

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The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling

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Bone Research 2022年第3期10卷 536-547页

作者： Jinlong Suo Sihai Zou Jinghui Wang Yujiao Han Lingli Zhang Chenchen Lv Bo Jiang Qian Ren Long Chen Lele Yang Ping Ji Xianyou Zheng Ping Hu Weiguo Zou department of Orthopedic Surgery and Institute of Microsurgery on Extremities Shanghai Jiaotong University Affiliated Sixth People’s Hospital200233 ShanghaiChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher EducationStomatological Hospital of Chongqing Medical University401147 ChongqingChina State Key Laboratory of cell biology Shanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell SciencesChinese Academy of SciencesUniversity of Chinese Academy of Sciences200031 ShanghaiChina Guangzhou Laboratory No.9 XingDaoHuan RoadGuanghzou International Bio lsland510005 GuangzhouChina Colorectal Cancer center/department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghaiChina Institute for stem cell and Regeneration Chinese Academy of Sciences100101 BeijingChina Bio-Research Innovation center Shanghai Institute of Biochemistry and Cell BiologySuzhouChina

Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ ***-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging.

关键词： adipocyte osteoporosis inhibiting

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Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene editing

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Journal of Genetics and Genomics 2017年第9期44卷 461-463页

作者： Leixin Wei Xiukun Wang Suming Yang Wen Yuan Jinsong Li department of Orthopaedic Surgery Changzheng Hospital The Second Military Medical University State Key Laboratory of cell biology Shanghai Key Laboratory of Molecular Andrology CAS Center for Excellence in Molecular Cell Science Institute of Biochemistry and Cell Biology Chinese Academy of SciencesUniversity of Chinese Academy of Sciences department of Orthopaedic Surgery Changzheng Hospital The Second Military Medical University

Generation of mouse models carrying a defined point mutation,especially disease-related point mutations,is of considerable interest for research in biology and *** standard method based on embryonic stem cell（ESC）-m... 详细信息

关键词： ESC AG Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene editing

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Anti-aging based on stem cell therapy:A scoping review

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World Journal of Experimental Medicine 2024年第3期14卷 57-63页

作者： Nassar El Assaad Alain Chebly Rawad Salame Robert Achkar Nour Bou Atme Khalil Akouch Paul Rafoul Colette Hanna Samer Abou Zeid Marwan Ghosn Charbel Khalil Faculty of Medicine Saint Joseph UniversityBeirut 961Lebanon Centre Jacques Loiselet for Medical Genetics and Genomics(CGGM) Faculty of MedicineSaint Joseph UniversityBeirut 961Lebanon Higher Institute of Public Health Saint Joseph UniversityBeirut 961Lebanon stem cell Therapy Lab Reviva Regenerative Medicine CenterBeirut 961Lebanon Poz Pozan University of Medical Sciences Pozan 034Poland department of Epidemiology and Biostatistics Faculty of Public HealthLebanese UniversityBeirut 961Lebanon School of Medicine Lebanese American UniversityBeirut 961Lebanon Bone Marrow Transplant Unit Burjeel Medical CityAbu Dhabi 999041United Arab Emirates

stem cells are present in the tissues and organs and remain in a quiescent and undifferentiated state until it is physiologically necessary to produce new descendant *** to their multipotency property,mesenchymal stem cells have attracted considerable attention worldwide due to their immunomodulation and therapeutic function in tissue *** cells secrete components such as paracrine factors,extracellular vesicles,and exosomes which have been shown to have anti-inflammatory,anti-aging,reconstruction and wound healing potentials in many in vitro and in vivo *** pluripotency and immunomodulatory features of stem cells could potentially be an effective tool in cell therapy and tissue *** affects the capacity for self-renewal and differentiation of stem cells,decreasing the potential for regeneration and the loss of optimal functions in organisms over *** progress in the field of cellular therapy and regenerative medicine has facilitated the evolution of particular guidelines and quality control approaches,which eventually lead to clinical *** therapy could potentially be one of the most promising therapies to control aging due to the fact that single stem cell transplantation can regenerate or substitute the injured *** understand the involvement of stem cells not only in tissue maintenance and disease but also in the control of aging it is important to know and identify their properties,functions,and regulation in vivo,which are addressed in this review.

关键词： Mesenchymal stem cell Anti-aging Telomerase Regenerative medicine stem cell therapy

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Long-term outcome of stem cell transplantation with and without anti-tumor necrotic factor therapy in perianal fistula with Crohn’s disease

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World Journal of stem cells 2024年第3期16卷 257-266页

作者： Min Young Park Yong Sik Yoon Jae Ha Park Jong Lyul Lee Chang Sik Yu Division of Colon and Rectal Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722South Korea Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND stem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease(CD).Anti-tumor necrotic factor(TNF)therapy combined with drainage procedure is effective as ***,previous studies are limited to proving whether the combination treatment of biologics and stem cell transplantation improves the effect of fistula *** This study aimed to evaluate the long-term outcomes of stem cell transplantation and compare Crohn’s perianal fistula(CPF)closure rates after stem cell transplantation with and without anti-TNF therapy,and to identify the factors affecting CPF closure and *** The patients with CD who underwent stem cell transplantation for treating perianal fistula in our institution between Jun 2014 and December 2022 were *** data were compared according to anti-TNF therapy and CPF *** A total of 65 patients were *** median age of females was 26 years(range:21-31)and that of males was 29(44.6%).The mean follow-up duration was 65.88±32.65 months,and complete closure was observed in 50(76.9%)*** closure rates were similar after stem cell transplantation with and without anti-TNF therapy(66.7%vs 81.6%at 3 year,P=0.098).The patients with fistula closure had short fistulous tract and infrequent proctitis and anorectal stricture(P=0.027,0.002,and 0.008,respectively).Clinical factors such as complexity,number of fistulas,presence of concurrent abscess,and medication were not significant for *** cumulative 1-,2-,and 3-year closure rates were 66.2%,73.8%,and 75.4%,*** Anti-TNF therapy does not increase CPF closure rates in patients with stem cell ***,both refractory and non-refractory CPF have similar closure rates after additional anti-TNF *** tract length,proctitis,and anal stricture are risk factors for non-closure in patients with CPF after stem cell transplantation.

关键词： Crohn’s disease Anus Fistula stem cell transplantation Tumor necrosis factor-alpha inhibitors Infliximab

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Alternative splicing: An important mechanism in stem cell biology

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World Journal of stem cells 2015年第1期7卷 1-10页

作者： Kenian Chen Xiaojing Dai Jiaqian Wu The Vivian L Smith department of Neurosurgery The Center for Stem Cell and Regenerative Medicine University of Texas Medical School at HoustonHouston TX 77030 United States

Alternative splicing(AS) is an essential mechanism in post-transcriptional regulation and leads to protein diversity. It has been shown that AS is prevalent in metazoan genomes, and the splicing pattern is dynamically regulated in different tissues and cell types, including embryonic stem cells. These observations suggest that AS may play critical roles in stem cell biology. Since embryonic stem cells and induced pluripotent stem cells have the ability to give rise to alltypes of cells and tissues, they hold the promise of future cell-based therapy. Many efforts have been devoted to understanding the mechanisms underlying stem cell selfrenewal and differentiation. However, most of the studies focused on the expression of a core set of transcription factors and regulatory RNAs. The role of AS in stem cell differentiation was not clear. Recent advances in highthroughput technologies have all owed the profiling of dynamic splicing patterns and cis-motifs that are responsible for AS at a genome-wide scale, and provided novel insights in a number of studies. In this review, we discuss some recent findings involving AS and stem cells. An emerging picture from these findings is that AS is integrated in the transcriptional and post-transcriptional networks and together they control pluripotency maintenance and differentiation of stem cells.

关键词： Alternative splicing stem cell Pluripotency Differentiation Splicing factor

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Site-directed RNA editing(SDRE):Off-target effects and their countermeasures

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Journal of Genetics and Genomics 2019年第11期46卷 531-535页

作者： Shaoshuai Mao Yajing Liu Shisheng Huang Xingxu Huang Tian Chi School of Life Sciences and Technology ShanghaiTech UniversityShanghai201210China CAS center for Excellence in Molecular cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China department of Immunobiology Yale University School of MedicineNew HavenCT 06520USA

Site-directed RNA editing(SDRE)is invaluable to basic research and clinical applications and has emerged as a new frontier in genome *** past few years have witnessed a surge of interest in SDRE,with SDRE tools emerging at a breathtaking ***,off-target effects of SDRE remain a tough problem,which constitutes a major hurdle to their clinical *** we discuss the diverse strategies for combating off-target editing,drawing lessons from the published studies as well as our ongoing ***,SDRE is still at its infancy,with significant challenges and exciting opportunities ahead.

关键词： Gene editing RNA editing Cas13 Off-target Specificity

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