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Inhibiting effect of Endostar combined with ginsenoside Rg3 on breast cancer tumor growth in tumor-bearing mice

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 178-181页

作者： Yun Zhang Qing-Zhan Liu su-Ping Xing Jin-Ling Zhang Oncology Department No.2 Linyi People's Hospital Radiotherapy Department Linyi People's Hospital

Objective: To study the inhibiting effect of Endostar combined with ginsenoside Rg3 on breast cancer tumor growth in tumor-bearing mice. Methods: Female mice were selected as experimental animals, and breast cancer tumor-bearing mouse models were established and then divided into group A, B, C and D that respectively received saline, recombinant human endostatin, ginsenosides Rg3 and recombinant human endostatin combined with Rg3 intervention; 7 d, 14 d and 21 d after intervention, tumor tissue volume was measured; 21 d after intervention, mice were killed, tumor tissue was collected, and m RNA contents of angiogenesis molecules, invasion molecules, autophagy marker molecules and autophagy signaling pathway molecules were detected. Results: At 7 d, 14 d and 21 d after intervention, tumor tissue volume of group B, C and D was lower than that of group A, and tumor tissue volume of group D was lower than that of group B and C; m RNA contents of VEGFA, VEGFB, VEGFC, MMP2, MMP9, p62, m TOR, PI3 K, Akt, JNK and Beclin-1 in tumor tissue of group B, C and D were significantly lower than those of group A, and LC3-II/LC3-I was significantly higher than that of group A; m RNA contents of VEGFA, VEGFB, VEGFC, MMP2, MMP9, p62, m TOR, PI3 K, Akt, JNK and Beclin-1 in tumor tissue of group D were significantly lower than those of group B and C, and LC3-II/LC3-I was higher than that of group B and C. Conclusions: Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug, and it can inhibit angiogenesis and cell invasion, and enhance cell autophagy.

关键词： Breast cancer Recombinant human endostatin Ginsenoside Rg3 Autophagy

Laparoscopic and open splenectomy and azygoportal disconnection for portal hypertension

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World Journal of Gastroenterology 2009年第27期15卷 3421-3425页

作者： Xiao-Zhong Jiang shao-Yong Zhao Hong Luo Bin Huang Chang-song Wang Lei Chen You-Jiang Tao Department of General surgery No. 2 People's Hospital of Yibin City Yibin 644000 Sichuan Province China

AIM： To compare the outcomes of laparoscopic and open splenectomy and azygoportal devascularization for portal hypertension. METHODs： From June 2006 to March 2009, laparoscopic splenectomy and azygoportal disconnection （LsD） were performed on 28 patients with cirrhosis, bleeding due to portal hypertension, and secondary hypersplenism. success was achieved in 26 patients. Demographic, intraoperative, and postoperative variables of the patients were compared. REsULTs： success of laparoscopic splenectomy and azygoportal disconnection was achieved in all but two patients （7.14%） who required open splenectomy and azygoportal devascularization （OsD）. The operation time was significantly longer in patients undergoing LsD than in those undergoing OsD （235 ± 36 min vs 178 ± 47 rain, P 〈 0.05）. The estimated intraoperative blood loss was much more in patients receiving OsD than in those receiving LsD （420 ± 50 mL vs 200 ± 30 mL, P 〈 0.01）. The proportion of patients undergoing laparoscopic and open splenectomy and azygoportal disconnection who received transfusion of packed red blood cells during or after the operation was 23.08% and 38.46%, respectively （P 〈 0.05）. The time of first oral intake was faster in patients after LsD than in those after OsD （1.5 ± 0.7 d vs 3.5 ± 1.6 d, P 〈 0.05）. The hospital stay of patients after LsD was shorter than that of patients after OsD （6.5 ± 2.3 d vs 11.7 ± 4.5 d, P 〈 0.05）. The pain requiring medication was less severe in patients after LsD than in those after OsD （7.69% vs 73.08%, P 〈 0.001）. The overall complication rate was lower in patients after LsD than in those after OsD （19.23% vs 42.31%, P 〈 0.05）.CONCLUsION： Laparoscopic splenectomy and azygoportal disconnection are the feasible, effective, and safe surgical procedure, and are advantageous over minimally invasive surgery for bleeding portal hypertension and hypersplenism.

关键词： Liver cirrhosis Portal hypertension Hypersplenism Laparoscopy Devascularization

Dynamic interaction nursing intervention on functional rehabilitation and self-care ability of patients after aneurysm surgery

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World Journal of Clinical Cases 2022年第15期10卷 4827-4835页

作者： Yan-E Xie Wei-Cheng Huang Yu-Ping Li Jia-Huan Deng Jian-Ting Huang The First Neurological Department Central People’s Hospital of Huizhou CityHuizhou 516001Guangdong ProvinceChina

BACKGROUND Nursing practices based on the dynamic interaction model have been shown to be superior to generic nursing ***,whether this model is effective in patients recovering from intracranial aneurysm surgery is not well *** To investigate the effect of nursing based on a dynamic interaction model on functional rehabilitation of patients after aneurysm *** A total of 86 cases in our hospital with intracranial aneurysm from April 2019 to April 2021,were selected and divided into the study group and the control group,with 43 patients in each *** control group received routine nursing,and the research group received nursing intervention based on a dynamic interaction *** daily living ability(activities of daily living,ADL),cognitive function(simple Intelligent Mental state scale,MMsE),quality of life(Generic Quality of Life Inventory-74,GQOL-74),self-care ability(Exercise of self-Care Agency scale),incidence of complications,and nursing satisfaction were recorded before and after *** Before intervention,ADL(52.09±6.44),MMsE(18.03±4.11),and GQOL-74(53.68±4.34)scores in the study group were not significantly different from those in the control group(ADL:50.97±7.32,MMsE:17.59±3.82,GQOL-74:55.06±3.98)(P>0.05).After intervention,ADL(86.12±5.07),MMsE(26.64±2.66),and GQOL-74(83.13±5.67)scores in the study group were higher than those in the control group(ADL:79.81±6.35,MMsE:24.51±3.00,and GQOL-74:77.96±6.27)(Pself-concept(17.46±4.44),self-care skills(25.22±4.20),self-care knowledge(22.35±4.74),and self-care responsibility(15.06±3.29)scores in the study group was similar to those in the control group(self-concept:16.89±5.53,self-care skills:24.59±4.46,self-care knowledge:21.80±3.61,and self-care responsibility:14.83±3.11)(P>0.05).After the intervention,self-concept(26.01±3.18),self-care skills(37.68±6.05),self-care knowledge(45.56±5.83),and self-care responsibility(22.01±3.77)scores in

关键词： Aneurysm Dynamic interaction model Functional rehabilitation self-care ability

In situ Deposition of Drug and Gene Nanoparticles on a Patterned supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

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Nano-Micro Letters 2024年第1期16卷 341-359页

作者： Jiawei Kang Yaping Li Yating Qin Zhongming Huang Yifan Wu Long sun Cong Wang Wei Wang Gang Feng Yiying Qi Department of Orthopaedic surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou City 310009Zhejiang ProvincePeople’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China ZJU-Hangzhou Global scientific and Technological Innovation Center Hangzhou 311215ZhejiangPeople’s Republic of China The Affiliated Nanhua hospital Orthopedic Research CentreHengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanPeople’s Republic of China Department of Radiology Jining No.1 People’s HospitalJining Medical UniversityJining 272000ShandongPeople’s Republic of China

The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage *** multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense ***,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their *** hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural *** resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and *** vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GsK-3β/β-catenin pathways,*** vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral *** biomaterial delivery approach represents a significant toward improved osteochondral repair.

关键词： Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a

Investigation of one-lung ventilation postoperative cognitive dysfunction and regional cerebral oxygen saturation relations

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2015年第12期16卷 1042-1048页

作者： Xi-ming LI Feng LI Zhong-kai LIU Ming-tao sHAO Department of Anesthesiology Linyi City People's Hospital Human Resource Department Linyi City People's Hospital Department of Emergency surgery Linyi City People's Hospital

Objective： To explore the relationship of postoperative cognitive dysfunction （POCD） in one-lung ventilation （OLV） patients and regional cerebral oxygen saturation （rsO2）. Methods： Twenty-nine male and twenty-one female cases of OLV received thoracic surgery, with American standards Association （AsA） physical status being at Grades Ⅰ-Ⅲ. Neuropsychological tests were performed on the day before operation and 7 d after operation, and there was an intraoperative continuous monitoring of rsO2. The values of rsO2 before anesthesia induction （t1）, at the beginning of OLV （t2）, and at the time of OLV 30 min （t3）, OLV 60 min （t4）, the end of OLV （t5）, and the end of surgery （t6） were recorded. The intraoperative average of rsO2 （ rsO2 ）, the intraoperative minimum value of rsO2 （rsO2, rn=n）, and the reduced maximum percentage of rsO2 （rsO2, %max） when compared with the baseline value were calculated. The volume of blood loss, urine output, and the amount of fluid infusion was recorded. Results： A total of 14 patients （28%） in the 50 cases suffered from POCD. The values of mini-mental state examination （MMsE）, the digit span and the digit symbol on the 7th day after the operation for POCD in OLV patients were found to be significantly lower than those before the operation （P〈0.05）. The values of MMsE and vocabulary fluency scores were significantly lower than those in the non-POCD group （P〈0.05）. The values of rsO2 in the POCD group of OLV patients at t2 and t3 and the values of rsO2 in the non-POCD group at t2 were found to be significantly higher than those at tl （P〈0.05）. The values of rsO2, %max in the POCD group were significantly higher than those in the non-POCD group （P〈0.05）. When the value of rsO2, %max is more than 10.1%, it may act as an early warning index for cognitive function changes, Conclusions： POCD after OLV may be associated with a decline in rsO2.

关键词： One-lung ventilation Postoperative cognitive dysfunction Regional cerebral oxygen saturation

Remote ischemic postconditioning protects against gastric mucosal lesions in rats

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World Journal of Gastroenterology 2014年第28期20卷 9519-9527页

作者： Tao Wang Ye-Ting Zhou Xin-Nian Chen An-Xiang Zhu Bo-Hua Wu Department of Anesthesiology Shuyang People’s Hospital Department of General surgery Shuyang People’s Hospital Institute of Pathophysiology School of Basic Medical SciencesLanzhou University Department of Pharmacy Shuyang People’s Hospital

AIM: To investigate the protective effects of remote ischemic postconditioning (RIP) against limb ischemia-reperfusion (IR)-induced gastric mucosal injury.

关键词： Remote ischemic postconditioning Limb ischemia-reperfusion Gastric ischemia Protection Rat

Cold atmospheric-pressure air plasma treatment of C6 glioma cells:effects of reactive oxygen species in the medium produced by the plasma on cell death

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Plasma science and Technology 2017年第2期19卷 63-68页

作者： Yuyang WANG Cheng CHENG Peng GAO shaopeng LI Jie sHEN Yan LAN Yongqiang YU Paul K CHU The first Affiliated hospital of Anhui Medical University Hefei 230032People's Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China Department of Physics and Materials science City University of Hong KongTatChee AvenueKowloonHong KongPeople's Republic of China

An atmospheric-pressure air plasma is employed to treat C6 glioma cells in vitro. To elucidate on the mechanism causing cell death and role of reactive species （Rs） in the medium produced by the plasma, the concentration of the long-lived Rs such as hydrogen peroxide, nitrate, and ozone in the plasma-treated liquid （phosphate-buffered saline solution） is measured. When vitamin C is added to the medium as a ROs quencher, the viability of C6 glioma cells after the plasma treatment is different from that without vitamin C. The results demonstrate that reactive oxygen species （ROs） such as H2O2, and O3 constitute the main factors for inactivation of C6 glioma cells and the reactive nitrogen species （RNs） may only play an auxiliary role in cell death.

关键词： atmospheric pressure air plasma reactive species cell death

Rare cause of cerebral venous sinus thrombosis:spontaneous intracranial hypotension syndrome:A case report

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World Journal of Clinical Cases 2023年第19期11卷 4677-4683页

作者： Pan Huang Department of Neurology People’s Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina

BACKGROUND spontaneous intracranial hypotension syndrome is a relatively uncommon neurological disorder of unknown etiology with a good *** venous sinus thrombosis is a specific type of cerebrovascular disease caused by multiple etiologies of cerebral venous sinus or vein thrombosis that obstructs cerebral venous return and is associated with impaired cerebrospinal fluid absorption;this entity is rarely seen *** intracranial hypotension syndrome is one of the causes of cerebral venous sinus thrombosis,and the probability of their combined occurrence is only 1%-2%.As such,it is easily overlooked clinically,thus increasing the difficulty of diagnosis and *** sUMMARY A 29-year-old young woman presented with postural *** puncture suggested a pressure of 50 mmH2O(normal 80 mmH2O-180 mmH2O),and magnetic resonance imaging cerebral venography suggested thrombosis of the supratentorial *** findings were considered indicative of cerebral venous sinus thrombosis due to spontaneous intracranial hypotension syndrome after ruling out immunological causes,tumor,infection,abnormal coagulation mechanism,and hypercoagulable state,*** was treated with rehydration and low-molecular heparin anticoagulation for 15 d,and follow-up magnetic resonance imaging cerebral venography suggested resolution of the *** patient had complete improvement of her headache *** spontaneous intracranial hypotension syndrome is one of the rare causes of cerebral venous sinus thrombosis,which is frequently misdiagnosed or missed and deserves consideration by clinicians during differential *** should be avoided in such patients,and early rehydration and anticoagulation therapy are effective treatment options.

关键词： spontaneous intracranial hypotension Cerebral venous sinus Thrombosis Rehydration Anticoagulation Case report

Epidemic Japanese B encephalitis combined with contactinassociated protein-like 2 antibody-positive autoimmune encephalitis:A case report

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World Journal of Clinical Cases 2023年第6期11卷 1379-1384页

作者： Pan Huang Department of Neurology People’s Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina

BACKGROUND It is not uncommon to develop viral *** Japanese B encephalitis infection combined with contactin-associated protein-like 2(CAsPR-2)antibody-positive autoimmune encephalitis has not been reported at *** clinical work,we need to consider more *** sUMMARY A 32-year-old male worker presented with headache,fever and call-unresponsive *** cranial magnetic resonance image showed symmetrical abnormal signals in bilateral medial temporal lobe,bilateral thalamus and basal *** lumbar puncture showed that cerebrospinal fluid protein and cell count increased *** encephalitis was considered,and the patient's consciousness still increased rapidly after antiviral *** detection of Cerebrospinal fluid Japanese B encephalitis virus Polymerase Chain Reaction positive,serum autoimmune encephalitis antibody showed CAsPR-2 antibody positive(1:320),the patient's condition gradually improved after plasma exchange treatment.3 mo later,the serum CAsPR-2 antibody was negative and the patient's condition was *** This article reports the world’s first case of Epidemic Japanese B encephalitis infection combined with CAsPR-2 antibody-positive autoimmune encephalitis,with a view to raising awareness.

关键词： Epidemic Japanese B encephalitis Contactin-associated protein-like 2 antibody Autoimmune encephalitis