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Pharmacological targeting cGAs/sTING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(spine surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina school of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAs/sTING/NF-κB ***,we found that targeting the cGAs/sTING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAs/sTING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAs/sTING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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science China Life sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie shusen Zheng Qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University school of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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A study on relationship of nitric oxide,oxidation,peroxidation,lipoperoxidation with chronic cholecystitis

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World Journal of Gastroenterology 2000年第4期6卷 501-507页

作者： Jun Fu Zhou Dong Cai You Gen Zhu Jin Lu Yang Cheng Hong Peng Yang Hai Yu The second Affiliated hospital of Medical College of Zhejiang University Hangzhou 310009ZhejiangChina the people’s hospital of jinhua city Jinhua 321000ZhejiangChina

AIM:To study relationship of injury induced by nitric oxide, oxidation, peroxidation,lipoperoxidation with chronic ***:The values of plasma nitric oxide (P-NO), plasma vitamin C (P-VC), plasma vitamin E (P-VE), plasma beta-carotene (P-beta-CAR), plasma lipoperoxides (P-LPO), erythrocyte superoxide dismutase (E-sOD), erythrocyte catalase (E-CAT), erythrocyte glutathione peroxidase (E-GsH-Px) activities and erythrocyte lipoperoxides (E-LPO) level in 77 patients with chronic cholecystitis and 80 healthy control subjects were determined, differences of the above average values between the patient group and the control group and differences of the average values between preoperative and postoperative patients were analyzed and compared, linear regression and correlation of the disease course with the above determination values as well as the stepwise regression and correlation of the course with the values were ***:Compared with the control group, the average values of P-NO, P-LPO, E-LPO were significantly increased (PsOD, E-CAT and E-GsH-Px decreased (P sis of the linear regression and correlation showed that with prolonging of the course, the values of P-NO, P-LPO and E-LPO in the patients were gradually ascended and the values of P-VC,P-VE, P-beta-CAR, E-sOD, E-CAT and E-GsH-Px descended (Psis of the stepwise regression and correlation indicated that the correlation of the course with P-NO, P-VE and P-beta-CAR values was the closest. Compared with the preoperative patients, the average values of P-NO, P-LPO and E-LPO were significantly decreased (P s of P-VC, E-sOD, E-CAT and E-GsH-Px in postoperative patients increased (P stoperative patients. But there was no significant difference in the average values of P-VE, P-beta-CAR preoperative and postoperative ***:Chronic cholec

关键词： nitric oxide oxidation peroxidation lipoperoxidation chronic cholecystitis

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Impact of cancer on mortality rates in patients with sepsis:A metaanalysis and meta-regression of current studies

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World Journal of Clinical Cases 2022年第21期10卷 7386-7396页

作者： Mei-Jiao Xiang Guo-Liang Chen Department of Comprehensive Intensive Care Unit Jinhua People’s HospitalJinhua 321000Zhejiang ProvinceChina Department of Hepatobiliary Pancreatic Gastrointestinal surgery Jinhua People's HospitalJinhua 321000Zhejiang ProvinceChina

BACKGROUND Research suggests that approximately 6%of adult patients admitted to hospitals in the United states present with sepsis and there has been a minimal change in the incidence of this condition in the last ***,patients with cancer generally have a higher incidence of sepsis due to immunosuppression caused by cancer or its *** To assess if cancer increases the mortality rates in sepsis patients by pooling evidence from contemporary *** PubMed,Embase,and Google scholar databases were searched from January 1,2001 to December 15,2021 for studies comparing outcomes of sepsis patients based on the presence of active *** data were pooled using a random-effects model,with the odds ratio(OR)and 95%confidence interval(CI)***-regression was conducted to assess the influence of confounders on mortality *** Nine studies were *** meta-analysis demonstrated a non-significant tendency towards increased risk of early mortality(OR=2.77,95%CI:0.88-8.66,I^(2)=99%)and a statistically significantly increased risk of late mortality amongst sepsis patients with cancer as compared to non-cancer sepsis patients(OR=2.46,95%CI:1.42-4.25,I^(2)=99%).Overall,cancer was found to significantly increase the risk of mortality in sepsis patients(OR=2.7,95%CI:1.07-6.84,I^(2)=99%).Metaanalysis indicated a statistically significantly increased risk of mortality in patients with solid tumors as well as hematological ***-regression indicated that an increase in the prevalence of comorbid pulmonary and renal diseases increased the risk of mortality in cancer patients with *** rates increased with an increase in the percentage of patients with urinary tract infections while an inverse relationship was seen for infections of cutaneous *** Contemporary evidence indicates that the presence of any cancer in sepsis patients significantly increases the risk of *** data sugg

关键词： sepsis septic shock Malignancy Immunocompromised Mortality

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Effects of sevoflurane preconditioning and postconditioning on rat myocardial stunning in ischemic reperfusion injury

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2010年第4期11卷 267-274页

作者： An-lu DAI Li-hua FAN Feng-jiang ZHANG Mei-juan YANG Jing YU Jun-kuan WANG Tao FANG Gang CHEN Li-na YU Min YAN Department of Anesthesiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Anesthesiology Lishui People's Hospital Lishui 323600 China Department of Anesthesiology Jinhua People's Hospital Jinhua 321300 China

Ischemic preconditioning and postconditioning distinctly attenuate ventricular arrhythmia after ischemia without affecting the severity of myocardial stunning. Therefore, we report the effects of sevofiurane preconditioning and postconditioning on stunned myocardium in isolated rat hearts. Isolated rat hearts were underwent 20 min of global ischemia and 40 min of reperfusion. After an equilibration period （20 min）, the hearts in the preconditioning group were exposed to sevoflurane for 5 min and next washout for 5 min before ischemia. Hearts in the sevoflurane postconditioning group underwent equilibration and ischemia, followed immediately by sevoflurane exposure for the first 5 min of reperfusion. The control group received no treatment before and after ischemia. Left ventricular pressure, heart rate, coronary flow, electrocardiogram, and tissue histology were measured as variables of ventricular function and cellular injury, respectively. There was no significant difference in the duration of reperfusion ventricular arrhythmias between control and sevoflurane preconditioning group （P=0.195）. The duration of reperfusion ventricular arrhythmias in the sevoflurane postconditioning group was significantly shorter than that in the other two groups （P〈0.05）. ＋（dPIdt）max in the sevoflurane preconditioning group at 5, 10, 15, 20, and 30 min after reperfusion was significantly higher than that in the control group （P〈0.05）, and there were no significant differences at 40 min after reperfusion among the three groups （P〉0.05）. As expected, for a 20-min general ischemia, infarct size in heart slices determined by 2,3,5-triphenyltetrazolium chloride staining among the groups was not obvious. sevofiurane postconditioning reduces reperfusion arrhythmias without affecting the severity of myocardial stunning. In contrast, sevoflurane preconditioning has no beneficial effects on reperfusion arrhythmias, but it is in favor of improving ventricular function and recovering myocardial

关键词： Inhalation anesthetics sevoflurane Postconditioning Preconditioning Ischemia-reperfusion injury Myocardial stunning

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Rectal tubular adenoma with submucosal pseudoinvasion misdiagnosed as adenocarcinoma:A case report

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World Journal of Gastrointestinal surgery 2022年第12期14卷 1418-1424页

作者： Dan Chen Ding-Fu Zhong Hong-Ying Zhang Ying Nie Dong Liu Department of Gastroenterology Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua People's HospitalJinhua 321000Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Gastroenterology Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua People's HospitalJinhua 321000Zhejiang ProvinceChina

BACKGROUND Differential diagnosis of colorectal intramucosal tumors from invasive adenocarcinoma is important in clinical practice due to the different risks of lymph node metastasis and different treatment *** phenomenon of a colorectal adenoma with part of the gland entering the submucosa is known as pseudoinvasion of the adenoma,which is a major challenge for pathological *** is essential to raise awareness of colorectal adenoma with submucosal pseudoinvasion clinically to avoid *** sUMMARY We describe a case of rectal adenoma with submucosal pseudoinvasion in a 48-year-old *** patient was admitted to jinhua people's hospital due to a change in stool habit for 5 *** performed colonoscopy,and the results suggested a submucosal bulge approximately 1.0 cm×1.0 cm in size in the rectum 8 cm from the anal verge,with red surface *** colonoscopy was also performed and a homogeneous hypoechoic mass about 0.52 cm×0.72 cm in size was seen at the lesion,protruding into the lumen with clear borders and invading the *** surgery was then performed and the pathological specimen showed a tubular adenoma with high-grade intraepithelial neoplasia(intramucosal carcinoma)involving the adenolymphatic *** addition,we performed a literature review of rectal tubular adenoma with submucosal pseudoinvasion to obtain a deeper understanding of this *** The aim of this study was to improve awareness of this lesion for clinicians and pathologists to reduce misdiagnosis.

关键词： Colorectal adenoma submucosal pseudoinvasion Ultrasound endoscopy Pathological diagnosis Treatment Case report

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sevoflurane postconditioning reduces myocardial reperfusion injury in rat isolated hearts via activation of PI3K/Akt signaling and modulation of Bcl-2 family proteins

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2010年第9期11卷 661-672页

作者： Li-na YU Jing YU Feng-jiang ZHANG Mei-juan YANG Ting-ting DING Jun-kuan WANG Wei HE Tao FANG Gang CHEN Min YAN Department of Anesthesiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Anesthesiology Jinhua People's Hospital Jinhua 321300 China

sevoflurane postconditioning reduces myocardial infarct *** objective of this study was to examine the role of the phosphatidylinositol-3-kinase(PI3K)/Akt pathway in anesthetic postconditioning and to determine whether PI3K/Akt signaling modulates the expression of pro-and antiapoptotic proteins in sevoflurane *** and perfused rat hearts were prepared first,and then randomly assigned to the following groups:sham-operation(sham),ischemia/reperfusion(Con),sevoflurane postconditioning(sPC),sham plus 100 nmol/L wortmannin(sham+Wort),Con+Wort,sPC+Wort,and Con+dimethylsulphoxide(DMsO).sevoflurane postconditioning was induced by administration of sevoflurane(2.5%,v/v) for 10 min from the onset of *** ventricular developed pressure(LVDP),left ventricular end-diastolic pressure(LVEDP),maximum increase in rate of LVDP(+dP/dt),maximum decrease in rate of LVDP(?dP/dt),heart rate(HR),and coronary flow(CF) were measured at baseline,R30 min(30 min of reperfusion),R60 min,R90 min,and R120 *** kinase(CK) and lactate dehydrogenase(LDH) were measured after 5 min and 10 min *** size was determined by triphenyltetrazolium chloride staining at the end of *** Akt and phosphorylated Akt(phospho-Akt),Bax,Bcl-2,Bad,and phospho-Bad were determined by Western blot *** of variance(ANOVA) and student-Newman-Keuls' test were used to investigate the significance of differences between *** LVDP,±dP/dt,and CF were higher and LVEDP was lower in the sPC group than in the Con group at all points of reperfusion(PsPC group had significantly reduced CK and LDH release and decreased infarct size compared with the Con group [(22.9±8)% vs.(42.4±9.4)%,respectively;PsPC group also had increased the expression of phospho-Akt,Bcl-2,and phospho-Bad,and decreased the expression of *** abolished the cardioprotection of sevoflurane *** postconditioning may prot

关键词： sevoflurane Postconditioning Cardioprotection Akt Bcl-2 Bad

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Predicting liver metastasis of gastrointestinal tract cancer by diffusion-weighted imaging of apparent diffusion coefficient values

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World Journal of Gastroenterology 2016年第10期22卷 3031-3037页

作者： De-Xian Zheng shu-Chun Meng Qing-Jun Liu Chuan-Ting Li Xi-Dan shang Yu-seng Zhu Tian-Jun Bai shi-Ming Xu Department of Radiology Second People’s Hospital of Liaocheng City Department of Radiology Third People’s Hospital of Liaocheng city Medical Imaging Institute of shandong Province Shandong Provincial Hospital Department of Gastroenterology Second People’s Hospital of Liaocheng city Department of Radiology People’s Hospital of Liaocheng city

AIM: To determine if efficacy of chemotherapy on liver metastasis of gastrointestinal tract cancer can be predicted by apparent diffusion coefficient(ADC) values of diffusion-weighted imaging(DWI). METHODs: In total, 86 patients with liver metastasis of gastrointestinal tract cancer(156 metastatic lesions) diagnosed in our hospital were included in this study. The maximum diameters of these tumors were compared with each other before treatment, 2 wk after treatment, and 12 wk after treatment. selected patients were classified as the effective group and the ineffective group, depending on the maximum diameter of the tumor after 12 wk of treatment; and the ADC values at different treatment times between the two groups were compared. spearman rank correlation was used to analyze the relationship between ADC value and tumor diameter. Receiver operating characteristic curve(ROC curve) was used to analyze the ADC values before treatment to predict the patient's sensitivity and specificity degree of efficacy to the chemotherapy. REsULTs: There was no difference in age between the two groups and in maximum tumor diameter before treatment and 2 wk after treatment. However, after 12 wk of treatment, maximum tumor diameter in the effective group was significantly lower than that in the ineffective group(P s in the ineffective group were significantly higher than those in the effective group(P s no difference in ADC values between the effective and ineffective groups after 2 and 12 wk of treatment. However, ADC values were significantly higher after 2 and 12 wk of treatment compared to before treatment in the effective group(P spearman rank correlation analysis showed that ADC value before treatment and the reduced percentage of the maximum tumor diameter after 12 wk of treatment were negatively correlated, while the increase in the percentage of the ADC value 12 wk after treatment and the decrease in the percentage

关键词： Chemotherapy Liver metastatic tumor Magnetic resonance imaging Gastrointestinal tract cancer

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Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences

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World Journal of Gastroenterology 2015年第3期21卷 944-952页

作者： Ya-Nan Gong You-Ming Li Ning-Min Yang Hong-Zhang Li Feng Guo Lang Lin Qun-Ying Wang Jia-Kun Zhang Zi-Zhong Ji Ji-Bo Mao Jun-Liang Mao Zheng-Chao shi Wu-Heng Tang Xin-Jian Zhu Wei shao Xiao-Feng Zhang Xing-Hua Wang Yue-Feng Tong Mi-Zu Jiang Guang-Lan Chen Zhi-Yong Wang Hui-Min Tu Guo-Fa Jiang Jian-sheng Wu Xu-Peng Chen Qiu-Long Ding Hong Ouyang Feng-Zhe Jin Yan-Li Xu Jian-Zhong Zhang state Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated hospital College of MedicineZhejiang University Zhiyuan Medical Inspection Institute Co. Ltd. sanmen people’s hospital The First people’s hospital of Xiaoshan District The First people’s hospital of Cangnan jinhua Municipal Central hospital The First people’s hospital of Pingyang The First hospital of Jiaxing Zhoushan hospital The First people’s hospital of Wenling Rui’an people’s hospital Maternal and Child Health hospital of Zhoushan city shangyu people’s hospital people’s hospital of Putuo District Zhoushan Hangzhou First people’s hospital Qingtian people’s hospital The First people’s hospital of Yongkang The Children’s hospital Zhejiang University school of Medicine Lishui people’s hospital The Affiliated hospital of Hangzhou Normal University Wuxi No.4 hospital Affiliated to suzhou University jinhua Wenrong hospital The First Affiliated hospital of Wenzhou Medical College Yueqing people’s hospital Tiantai people’s hospital Lin’an people’s hospital Rui’an city TCM hospital Medical College of Hebei University of Engineering

AIM:To evaluate the efficacy of centralized culture and possible influencing ***:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(***) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal *** mucosal biopsies were taken from the antrum for *** biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 *** culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 *** additional 5736 biopsies from ***-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory ***:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the ***-positive quality control *** the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport *** contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P sportation,the average natural temperature increased from 4.67 to 29.14℃,while the positive culture rate declined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUsION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter *** samples.

关键词： Centralized isolation Helicobacter pylori Influenc

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Early endoscopic management of an infected acute necrotic collection misdiagnosed as a pancreatic pseudocyst: A case report

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World Journal of Gastrointestinal surgery 2024年第2期16卷 609-615页

作者： Hong-Ying Zhang Chen-Cong He Department of Gastroenterology Jinhua People's HospitalJinhua 321000Zhejiang ProvinceChina Department of General Medicine Jinhua Guangfu HospitalJinhua 321001Zhejiang ProvinceChina

BACKGROUND Infected acute necrotic collection(ANC)is a fatal complication of acute pancre-atitis with substantial morbidity and *** plays an exceedingly important role as the first step in invasive intervention for infected necrosis;however,there is great controversy about the optimal drainage time,and better treatment should be *** sUMMARY We report the case of a 43-year-old man who was admitted to the hospital with severe intake reduction due to early satiety 2 wk after treatment for acute pancre-atitis;conservative treatment was ineffective,and a pancreatic pseudocyst was suspected on contrast-enhanced computed tomography(CT).Endoscopic ultra-sonography(EUs)suggested hyperechoic necrotic tissue within the cyst *** wall was not completely mature,and the culture of the puncture fluid was positive for A-haemolytic ***,the final diagnosis of ANC in-fection was *** necrotic collection was not walled off and contained many solid components;therefore,the patient underwent EUs-guided aspiration and *** weeks after the collection was completely encapsulated,pancreatic duct stent drainage via endoscopic retrograde cholangiopancreatography(ERCP)was performed,and the patient was subsequently successfully *** repeat CT,the pancreatic cysts had almost disappeared during the 6-month fo-llow-up period after *** Early EUs-guided aspiration and lavage combined with late ERCP catheter drainage may be effective methods for intervention in infected ANCs.

关键词： Infected acute necrotic collection Pancreatic pseudocyst Endoscopic ultrasonography Endoscopic retrograde cholangiopancreatography Endoscopic ultrasound-guided fine-needle aspiration Case report

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