Impact of cancer on mortality rates in patients with sepsis:A metaanalysis and meta-regression of current studies

作     者：Mei-Jiao Xiang Guo-Liang Chen 

作者机构：Department of Comprehensive Intensive Care UnitJinhua People’s HospitalJinhua 321000Zhejiang ProvinceChina Department of Hepatobiliary Pancreatic Gastrointestinal SurgeryJinhua People's HospitalJinhua 321000Zhejiang ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第21期

页      面：7386-7396页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Sepsis Septic shock Malignancy Immunocompromised Mortality 

摘      要：BACKGROUND Research suggests that approximately 6%of adult patients admitted to hospitals in the United States present with sepsis and there has been a minimal change in the incidence of this condition in the last ***,patients with cancer generally have a higher incidence of sepsis due to immunosuppression caused by cancer or its *** To assess if cancer increases the mortality rates in sepsis patients by pooling evidence from contemporary *** PubMed,Embase,and Google Scholar databases were searched from January 1,2001 to December 15,2021 for studies comparing outcomes of sepsis patients based on the presence of active *** data were pooled using a random-effects model,with the odds ratio(OR)and 95%confidence interval(CI)***-regression was conducted to assess the influence of confounders on mortality *** Nine studies were *** meta-analysis demonstrated a non-significant tendency towards increased risk of early mortality(OR=2.77,95%CI:0.88-8.66,I^(2)=99%)and a statistically significantly increased risk of late mortality amongst sepsis patients with cancer as compared to non-cancer sepsis patients(OR=2.46,95%CI:1.42-4.25,I^(2)=99%).Overall,cancer was found to significantly increase the risk of mortality in sepsis patients(OR=2.7,95%CI:1.07-6.84,I^(2)=99%).Metaanalysis indicated a statistically significantly increased risk of mortality in patients with solid tumors as well as hematological ***-regression indicated that an increase in the prevalence of comorbid pulmonary and renal diseases increased the risk of mortality in cancer patients with *** rates increased with an increase in the percentage of patients with urinary tract infections while an inverse relationship was seen for infections of cutaneous *** Contemporary evidence indicates that the presence of any cancer in sepsis patients significantly increases the risk of *** data sugg