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Gemini Dressing with Both super‑hydrophilicity and ‑hydrophobicity Pursuing Isolation of Blood Cells for Hemostasis and Wound Healing

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Advanced Fiber Materials 2023年第4期5卷 1447-1466页

作者： Qing Li Enling Hu Kun Yu Ruiqi Xie Fei Lu Bitao Lu Rong Bao Fangyin Dai Guangqian Lan state Key Laboratory of silkworm Genome Biology College of Sericulture Textile and Biomass ScienceSouthwest UniversityChongqing 400715China chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China The ninth people’s hospital of chongqing No.69 Jialing VillageBeiBei DistrictChongqing 400715China

Achieving efficient hemostasis and wound management is vital to preserve life and restore health in case of extensive hemor-rhagic skin ***,we develop a filter pump-like hierarchical porous-structure(HPs)dressing based on a non-woven substrate,konjac glucomannan(KGM)aerogel,and bi-functional microporous starch(BMs).The KGM aerogel intercalates into the non-woven network structure,forming a hydrophilic frame to stimulate the plasma permeation toward the interior in synergy with the hydrophilic pores of the *** BMs surface forms a hydrophobic matrix that fills the spaces of the KGM hydrophilic frame,contributing to the isolation and aggregation of blood cells on the surface of the HPs dressing to establish rapid *** model experiments suggest reliable HPs dressing hemostatic capacity,as it is able to stop ear artery and liver bleeding within 97.6±15.2 s and 67.8±5.4 s,***,the dressings exhibit antibacterial properties and enabled wound healing within 2 *** vitro hemolysis and cytotoxicity tests also confirm the biocompatibility of HPs *** novel“two-in-one”hemostatic dressing facilitates tissue repair of bleeding wounds over the entire recovery period,thereby providing a convenient strategy for wound management.

关键词： Hierarchical porous-structure Blood cell isolation Hemostasis Antibacterial activity Wound healing

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Magnetic field-mediated Janus particles with sustained driving capability for severe bleeding control in perforating and inflected wounds

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Bioactive Materials 2021年第12期6卷 4625-4639页

作者： Qing Li Enling Hu Kun Yu Mengxing Lu Ruiqi Xie Fei Lu Bitao Lu Rong Bao Guangqian Lan state Key Laboratory of silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China The ninth people’s hospital of chongqing No.69 Jialing VillageBeiBei DistrictChongqing400715China

severe bleeding in perforating and inflected wounds with forky cavities or fine voids encountered during prehospital treatments and surgical procedures is a complex ***,we present a novel hemostatic strategy based on magnetic field-mediated *** biphasic Janus magnetic particle(Mss@Fe2O3-T)comprised aggregates ofα-Fe2O3 nanoparticles(Fe_(2)O_(3) NPs)as the motion actuator,negatively modified microporous starch(Mss)as the base hemostatic substrate,and thrombin as the loaded hemostatic *** application,the particles were first wrapped using NaHCO_(3) and then doped with protonated tranexamic acid(TXA-NH_(3)^(+)),which ensured their high self-dispersibility in *** application,the particles promptly self-diffused in blood by bubble propulsion and travelled to deep bleeding sites against reverse rushing blood flow under magnetic *** vivo tests confirmed the superior hemostatic performance of the particles in perforating and inflected wounds(“V”-shaped femoral artery and“J”-shaped liver bleeding models).The present strategy,for the first time,extends the range of magnetically guided drug carriers to address the challenges in the hemorrhage control of perforating and inflected wounds.

关键词： Janus particle sustained driving Magnetic guidance Hemostasis Complex wound

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Microcluster colloidosomes for hemostat delivery into complex wounds:A platform inspired by the attack action of torpedoes

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Bioactive Materials 2022年第10期7卷 372-387页

作者： Bitao Lu Enling Hu Ruiqi Xie Kun Yu Fei Lu Rong Bao Chenhui Wang Guangqian Lan Fangyin Dai state Key Laboratory of silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China the ninth people’s hospital of chongqing no.69 jialing village BeiBei DistrictChongqing400715China chongqing Key Laboratory of Natural Product synthesis and Drug Research School of Pharmaceutical SciencesChongqing University55 South Daxuecheng RoadChongqing401331China

Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature,thereby causing massive blood loss and significantly increased *** by the attack action of torpedoes,we synthesized microcluster(MC)colloidosomes equipped with magnetic-mediated navigation and“blast”systems to deliver hemostats into the cavity of vase-type ***_(3)/Fe_(2)O_(3)(CF)microparticles functionalized with Arg-Gly-Asp(RGD)modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots(CDs)to form MC colloidosomes,which were loaded with thrombin and protonated tranexamic acid(TXA-NH_(3)^(+)).The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH_(3)^(+).The CO_(2) bubbles generated during disassembly produced a“blast”that propelled thrombin into the wound *** bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within~60 ***,in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC *** study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis,creating a new paradigm for combating trauma treatment.

关键词： Torpedoes-inspired Microcluster colloidosomes Magnetic guidance Disintegration Hemostasis

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