Magnetic field-mediated Janus particles with sustained driving capability for severe bleeding control in perforating and inflected wounds

作     者：Qing Li Enling Hu Kun Yu Mengxing Lu Ruiqi Xie Fei Lu Bitao Lu Rong Bao Guangqian Lan 

作者机构：State Key Laboratory of Silkworm Genome BiologyCollege of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern TextileChongqing400715China The Ninth People’s Hospital of ChongqingNo.69 Jialing VillageBeiBei DistrictChongqing400715China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第12期

页      面：4625-4639页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：This work was supported by the National Natural Science Foundation of China(No.51703185,51803170,and 51803171) the Fundamental Research Funds for the Central Universities(nos.XDJK2019AC003 and XDJK2020B017) 

主　　题：Janus particle Sustained driving Magnetic guidance Hemostasis Complex wound 

摘      要：Severe bleeding in perforating and inflected wounds with forky cavities or fine voids encountered during prehospital treatments and surgical procedures is a complex ***,we present a novel hemostatic strategy based on magnetic field-mediated *** biphasic Janus magnetic particle(MSS@Fe2O3-T)comprised aggregates ofα-Fe2O3 nanoparticles(Fe_(2)O_(3) NPs)as the motion actuator,negatively modified microporous starch(MSS)as the base hemostatic substrate,and thrombin as the loaded hemostatic *** application,the particles were first wrapped using NaHCO_(3) and then doped with protonated tranexamic acid(TXA-NH_(3)^(+)),which ensured their high self-dispersibility in *** application,the particles promptly self-diffused in blood by bubble propulsion and travelled to deep bleeding sites against reverse rushing blood flow under magnetic *** vivo tests confirmed the superior hemostatic performance of the particles in perforating and inflected wounds(“V-shaped femoral artery and“J-shaped liver bleeding models).The present strategy,for the first time,extends the range of magnetically guided drug carriers to address the challenges in the hemorrhage control of perforating and inflected wounds.