Gemini Dressing with Both Super‑hydrophilicity and ‑hydrophobicity Pursuing Isolation of Blood Cells for Hemostasis and Wound Healing

作     者：Qing Li Enling Hu Kun Yu Ruiqi Xie Fei Lu Bitao Lu Rong Bao Fangyin Dai Guangqian Lan 

作者机构：State Key Laboratory of Silkworm Genome BiologyCollege of Sericulture Textile and Biomass ScienceSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern TextileChongqing 400715China The Ninth People’s Hospital of ChongqingNo.69 Jialing VillageBeiBei DistrictChongqing 400715China 

出 版 物：《Advanced Fiber Materials》 (先进纤维材料（英文）)

年 卷 期：2023年第5卷第4期

页      面：1447-1466页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China(No.52103096) Natural Science Foundation of Chongqing,China(Nos.cstb2022nscq-msx0555 and cstc2020jcyj-msxmX0024) Fundamental Research Funds for Central Universities(Nos.SWU-XDPY22010,XDJK2019AC003,and XDJK2020B017) 

主　　题：Hierarchical porous-structure Blood cell isolation Hemostasis Antibacterial activity Wound healing 

摘      要：Achieving efficient hemostasis and wound management is vital to preserve life and restore health in case of extensive hemor-rhagic skin ***,we develop a filter pump-like hierarchical porous-structure(HPS)dressing based on a non-woven substrate,konjac glucomannan(KGM)aerogel,and bi-functional microporous starch(BMS).The KGM aerogel intercalates into the non-woven network structure,forming a hydrophilic frame to stimulate the plasma permeation toward the interior in synergy with the hydrophilic pores of the *** BMS surface forms a hydrophobic matrix that fills the spaces of the KGM hydrophilic frame,contributing to the isolation and aggregation of blood cells on the surface of the HPS dressing to establish rapid *** model experiments suggest reliable HPS dressing hemostatic capacity,as it is able to stop ear artery and liver bleeding within 97.6±15.2 s and 67.8±5.4 s,***,the dressings exhibit antibacterial properties and enabled wound healing within 2 *** vitro hemolysis and cytotoxicity tests also confirm the biocompatibility of HPS *** novel“two-in-onehemostatic dressing facilitates tissue repair of bleeding wounds over the entire recovery period,thereby providing a convenient strategy for wound management.