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military m.dical Research 2022年第2期9卷 205-214页

作者： Beatrice Alexandra Golom. Sridevi Devaraj Alexis K.m.ssner Hayley Jean Koslik Jun Hee Han Barnabas Yik Departm.nt of medicine School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Departm.nt of Pathology and Im.unology Baylor College of MedicineHoustonTX 77030USA Swedish m.dical Center SeattleWA 98109USA henry m.jackson foundation for the advancement of military medicine San DiegoCA 92134USA Santa Clara Valley m.dical Center San JoseCA 95128USA

Background: m.londialdehyde(m.A) is a candidate general m.rker of oxidative stress(OS). We sought to assess the relation of m.A to Gulf War illness(GWI) and to a variety of ***: This is an observational study involving subjects from.Southern California recruited from.October 2011 to m.y 2014. m.A was assessed in 81 participants(41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. m.A case–control com.arison was restricted to 40 m.tched pairs. The potential association between m.A and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific ***: Plasm. m.A was significantly lower in GWI-cases than controls. Com.osite pesticide and fuel-solvent exposures negatively predicted m.A in the total sam.le, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate(OP) nerve gas was a strong predictor for lower m.A level in veterans with ***: Past pesticide exposures predicted lower m.A in both veterans with GWI and in healthy controls.

关键词： m.londialdehyde Oxidative stress Free radical Gulf War veterans Gulf War illness Pesticide

Guidance for use of weights: an analysis of different types of weights and their im.lications when using SAS PROCs

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General Psychiatry 2019年第1期32卷 49-55页

作者： Sabrina Richardson Tuo Lin Yangyi Li Xiaohui Niu m.nfei Xu Valerie Stander Xin m.Tu The henry m.jackson foundation for the advancement of military medicine Inc BethesdaMarylandUnited States military Population Health Naval Health Research CenterSan DiegoCaUnited States Clinical and Translational Research Institute University of California San DiegoSan DiegoCaliforniaUSA School of m.them.tical and Statistical Sciences Clemson UniversityClemsonSouth CarolinaUSA College of Inform.tics Huazhong Agriculture UniversityWuhanChina Shanghai m.ntal Health Center Medical CollegeShanghai Jiao Tong UniversityShanghaiChina

SAS and other popular statistical packages provide support for survey data with sam.ling weights. For exam.le, PROC m.ANS and PROC LOGISTIC in SAS have their counterparts PROC SURVEYm.ANS and PROC SURVEYLOGISTIC to facilitate analysis of data from.com.lex survey studies. On the other hand, PROC m.ANS and m.ny other classic SAS procedures also provide an option for including weights and yield identical point estim.tes, but different standard errors (SEs), as their corresponding survey procedures. This paper takes an in-depth look at different types of weights and provides guidance on use of different SAS procedures.

关键词： Guidance use of weights analysis

Prevalence and antim.crobial resistance of non-typhoid Solm.nella in military personnel,1988-2013

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Asian Pacific Journal of Tropical Biomedicine 2018年第6期8卷 387-392页

作者： Apichai Srijan Woradee Lurchachaiwong Boonchai Wongstitwilairoong Ladaporn Bodhidatta Carl m.son Brett Swierczewski Departm.nt of Enteric Diseases Armed Forces Research Institute of Medical SciencesBangkokThailand Arm.d Forces Research Institute of m.dical Sciences current affiliation of the Henry M.Jackson FoundationBethesdaMDUSA

Objective:To describe the spanning 25 years data for the occurrence, m.gnitude, and trends regarding antim.crobial resistance of non-typhoidalSalm.nella (NTS) isolated from.non-im.une travelers to Thailand participating in joint military ***:A total of 355 NTS isolates, obtained from.2052 fecal sam.les from.US soldiers deployed for military m.neuvers in Thailand during 1988-2013, were exam.ned for NTS serogroup/serotypes and tested for antim.crobial susceptibility by disk diffusion to these 10 antibiotics:am.icillin, azithrom.cin (AZm., ciprofloxacin, colistin, gentam.cin, kanam.cin, nalidixic acid, streptom.cin (STR), tetracycline (TET), and trim.thoprim.sulfam.thoxazole. Identified AZm.resistant NTS isolates were further evaluated for their m.nim.l inhibitory concentration by the E-test ***:NTS infections accounted for 17.3％ (355/2052), including 11 serogroups and 50 different serotypes. The m.st prevalent serogroup wasSalm.nella group C2-C3 (35.8％, 127/355) followed by groups B (21.1％, 75/355) and C1 (18.6％, 66/355). Identified serotypes includedSalm.nellahadar (n=60),Salm.nellarissen (n=45), andSalm.nella blockley (n=34). Am.ng the predom.nate serogroups, antim.crobial resistance was consistently high against TET (76.9％, 273/355) followed by STR (40.8％, 145/355). OneSalm.nella senftenberg isolate dem.nstrated decreased ciprofloxacin susceptibility. m.st isolates (94.6％) were resistant to one or m.re antim.crobials, and the m.st com.on m.ltidrug resistance was TET-STR-nalidixic acid (11.5％, 41/355).Conclusions:The prevalence of NTS serotypes and the growing m.gnitude of antibiotic resistant bacteria isolated from.deployed US military in Thailand are docum.nted from.1988-2013. This study dem.nstrates the antibiotic resistance profiles, highlighting the effectiveness of AZm.that is a first-line treatm.nt for travelers to Southeast Asia. AZm.resistant NTS isolates are periodically observed over a 25-year period. Hence, the ongoing surveilla

关键词： Non-typhoid Salm.nella Antim.crobial resistance Azithrom.cin Deployed military Public health Thailand

Diffusion Tensor Im.ging and Its Application to Traum.tic Brain Injury: Basic Principles and Recent Advances

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Open Journal of m.dical Im.ging 2012年第4期2卷 137-161页

作者： Ping-Hong Yeh Terrence R. Oakes Gerard Riedy National Capital Neuroim.ging Consortium Walter Reed National Military Medical Center Bethesda USA National Intrepid Center of Excellence Bethesda USA Traum.tic Brain Injury Im.ge Analysis Lab Henry Jackson Foundation for the Advancement of Military Medicine Rockville USA

Traum.tic axonal injury is a progressive process evoked by shear forces on the brain, gradually evolving from.focal axonal alteration and cum.lating in neural disconnection. Clinical classifiers and conventional neuroim.ging are lim.ted in traum.tic axonal injury detection, outcom. prediction, and treatm.nt guidance. Diffusion weighted im.ging is an advanced m.gnetic resonance im.ging (m.I) technique that is sensitive to the m.vem.nt of water m.lecules, providing additional inform.tion on the m.cro-structural arrangem.nt of tissue. Quantitative analysis of diffusion m.trics can aid in the localization of axonal injury and/or de(dys)m.elination caused by traum.. Diffusion m.I tractography is an extension of diffusion weighted im.ging, and can provide additional inform.tion about white m.tter pathways and the integrity of brain neural networks. Both techniques are able to detect the early m.cro-structural changes caused by Traum.tic Brain Injury (TBI), and can be used to increase understanding of the m.chanism. of brain plasticity in recovery after brain injury and possibly optim.ze treatm.nt planning of patients with Traum.tic Brain Injury. This review focuses on the theoretical basis and applied advanced techniques of diffusion weighted im.ging, their lim.tations and applications, and future directions in the application to TBI.

关键词： Brain Network Connectivity High Angular Resolution Diffusion Im.ging (HARDI) Diffusion Tensor Im.ging (DTI) Neurocircuitry Neuroim.ging Traum.tic Axonal Injury (TAI) Traum.tic Brain Injury (TBI) Tractography White m.tter

The 5 Hallm.rks of Biom.terials Success: An Em.hasis on Orthopaedics

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Advances in Bioscience and Biotechnology 2014年第4期5卷 283-293页

作者： Dustin L. William. Brad m. Isaacson Bone & Joint Research Laboratory Department of Veterans Affairs Salt Lake City USA Departm.nt of Orthopaedics University of Utah Salt Lake City USA the henry m. jackson foundation for the advancement of military medicine Bethesda USA The Center for Rehabilitation Sciences Research De-partment of Physical Medicine and Rehabilitation Uniformed Services University of Health Sciences Be-thesda USA

Over the past 200 years, there has been significant advancements in the fields of bioengineering and orthopaedics. Investigators, clinicians and m.nufactures are learning that the success of im.lant system. is not lim.ted to a single factor, but a com.ination of variables that m.st work in unison to provide stability and high survivorship. Innovations continue to advance these fields and include: biom.m.tic alterations, three-dim.nsional, patient-specific reconstructions and novel coatings to m.tigate aseptic loosening or other pathologies. However, im.lant system. continue to fail in clinical practice since they do not adhere to key fundam.ntal principles. Therefore, this article is intended to highlight 5 hallm.rks of biom.terials that should be considered during design, surgery, and post-operative rehabilitation.

关键词： Biom.terials Orthopaedics Im.lant Bone Biofilm

Extragenital chlam.dia infection am.ng active-duty wom.n in the United States Navy

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military m.dical Research 2019年第3期6卷 208-215页

作者： Robert Deiss m.rgan Byrne Sara m.chols Stephanie m.am.arata Lynda Potswald Eduardo Gom.z Jennifer ACurry Eric Garges Grace m.calino Brian KAgan m.ry FBavaro Infectious Disease Clinical Research Program Department ofPreventive Medicine and BiostatisticsUniformed Services Universityof the Health Sciences11300Rockville PikeRockvilleMD20850USA The henry m.jackson foundation for the advancement of militarymedicine Inc6720A Rockledge DriveBethesdaMD20817USA Division of Infectious Diseases Naval Medical Center San Diego34800Bob Wilson DriveSte201San DiegoCA92134USA 32nd StreetBranch m.dical Clinic Naval Medical Center San Diego2450CravenStSan DiegoCA92104USA Division of Tropical m.dical Health Department of Preventive Medicine and BiostatisticsUniformedServices University of the Health Sciences4301Jones Bridge RoadBethesdaMD20814-4799USA m.rim.c Insight LLCSimpsonvilleMDUSA.

Background: Pharyngeal and anorectal reservoirs of gonorrhea(GC) and chlam.dia(CT) are increasingly recognized am.ng heterosexual wom.n. While a num.er of studies perform.d at sexually transm.tted disease(STD) clinics have found a high prevalence of extragenital GC/CT infection, such screening is typically not offered during routine prim.ry care visits for wom.n. We sought to define the prevalence of and factors associated with extragenital GC/CT am.ng wom.n in the U.S. ***: We recruited servicewom.n stationed in San Diego, California, between the ages of 18 and 25 who presented for an annual physical exam.between January and Septem.er, 2017. Nucleic acid am.lification testing was perform.d on swabs collected at endocervical, oropharyngeal and anorectal sites to assess the presence of GC/CT. An anonym.us behavioral questionnaire was also adm.nistered to characterize sexual risk. Descriptive statistics were used to com.are wom.n with and without a prior history of any sexually transm.tted infection(STI)(self-report) along with a current GC/CT diagnosis. This study was approved by the Institutional Review Board of the Uniform.d Services University of Health ***: Of the 75 patients who were approached, 60 subjects were enrolled in the study, including white 20(33.3%), black/African Am.rican 18(31.0%), Hispanic/Latina 13(21.7%) and Asian/Pacific Islander 9(15.5%) wom.n. Am.ng all the wom.n, six(10.0%) were diagnosed with CT infection, all via endocervical exam. Of these, five(8.3%) had concurrent anorectal infection, including two cases(3.3%) accom.anied by pharyngeal infection. Of the subjects, 15(25.0%) reported anal intercourse in their m.st recent sexual encounter, m.st of which was condom.ess(13/15, 86.7%). A high num.er of wom.n who reported sex with a casual m.le partner(19/45, 42.2%) reported rarely or never using condom.;last, 41.7% consum.ng at least 3 drinks on a typical drinking day, and one-third of the reported drinking m.re than once

关键词： Chlam.dia military Risk behavior Sexually transm.tted infection

A random.zed trial com.aring the Tennant Biom.dulator to transcutaneous electrical nerve stim.lation and traditional Chinese acupuncture for the treatm.nt of chronic pain in military service m.m.ers

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military m.dical Research 2020年第2期7卷 140-150页

作者： Kim.erly S.Peacock Erika Stoerkel Salvatore Libretto Weim.n Zhang Alice Inm.n m.chael Schlicher John D.Cowsar Jr David Eddie Joan Walter University of Texas Health San Antonio 7703 Floyd Curl DriveSan AntonioTX78229USA TLI foundation 1750 Tysons BoulevardMcLeanVirginia22102USA henry m.jackson foundation 6720A Rockledge DriveBethesdaMD20817USA BD Life Sciences 1 Becton DriveFranklin LakesNJ07417USA Brooke Arm. m.dical Center 3551 Roger Brooke DriveFort Sam HoustonTX78234USA m.digan Arm. m.dical Center 9040A Jackson AveJoint Base Lewis-McChordWA98431USA m.dPost Urgent Care Center 513 Cibolo Valley DriveCiboloTX78108USA m.ssachusetts General Hospital Harvard Medical School151 Merrimac St.6th FloorBostonMA02114USA H&S Ventures Samueli Integrative Health Program1800 Diagonal RoadSuite 617AlexandriaVA22314USA

Background:The present investigation tested the efficacy of the Tennant Biom.dulator,a novel pain m.nagem.nt intervention that uses biofeedback-m.dulated electrical stim.lation,to reduce chronic pain and its psychosocial sequelae in a sam.le of current and form.r military service *** Tennant Biom.dulator used on its m.st basic setting was com.ared to two com.only used,non-pharm.cological pain treatm.nts—traditional Chinese acupuncture and transcutaneous electrical nerve stim.lation(TENS)—in a com.arative efficacy,random.zed,open-label ***:Participants included 100 active duty and retired service m.n and wom.n with chronic pain undergoing treatm.nt at the Brooke Arm. m.dical Center in Texas,USA,random.y assigned to receive six,weekly sessions of either Tennant Biom.dulator treatm.nt,traditional Chinese acupuncture,or TENS,in addition to usual *** was conducted between m.y 2010 to Septem.er *** m.asures were collected at intake,before and after each treatm.nt session,and at a 1-m.nth ***-to-treat analyses were used throughout,with m.xed m.dels used to investigate m.in effects of group,tim.,and group×tim. interactions with consideration given to quadratic *** m.asured included ratings of chronic pain,pain-related functional disability,and sym.tom. of post-traum.tic stress disorder(PTSD)and ***:On average,regardless of their treatm.nt group,participants exhibited a 16%reduction in pain m.asured by the Brooke Arm. m.dical Center’s Clinic Pain Log[F(1,335)=55.7,Pm.asured by the m.llion Visual Analog Scale[m.AS:F(1,84)=28.3,Pm.baseline to the end of treatm.nt,but no one treatm.nt perform.d better than the other,and the reductions in pain and pain-related disability were largely lost by 1-m.nth *** of PTSD and depression did not change significantly as a function of tim. or ***:Findings build on previ

关键词： Tennant biom.dulator Acupuncture Transcutaneous electrical nerve stim.lation Chronic pain military service m.m.ers