Lower blood malondialdehyde is associated with past pesticide exposure:findings in Gulf War illness and healthy controls

作     者：Beatrice Alexandra Golomb Sridevi Devaraj Alexis K.Messner Hayley Jean Koslik Jun Hee Han Barnabas Yik Beatrice Alexandra Golomb;Sridevi Devaraj;Alexis K.Messner;Hayley Jean Koslik;Jun Hee Han;Barnabas Yik

作者机构：Department of MedicineSchool of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Department of Pathology and ImmunologyBaylor College of MedicineHoustonTX 77030USA Swedish Medical CenterSeattleWA 98109USA Henry M.Jackson Foundation for the Advancement of Military MedicineSan DiegoCA 92134USA Santa Clara Valley Medical CenterSan JoseCA 95128USA 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2022年第9卷第2期

页      面：205-214页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

基　　金：funded by the Depar tment of Defense Congressionally Directed Medical Research Program (GW093063) 

主　　题：Malondialdehyde Oxidative stress Free radical Gulf War veterans Gulf War illness Pesticide 

摘      要：Background: Malondialdehyde(MDA) is a candidate general marker of oxidative stress(OS). We sought to assess the relation of MDA to Gulf War illness(GWI) and to a variety of ***: This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants(41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. MDA case–control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific ***: Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate(OP) nerve gas was a strong predictor for lower MDA level in veterans with ***: Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.