The 5 Hallmarks of Biomaterials Success: An Emphasis on Orthopaedics

作     者：Dustin L. Williams Brad M. Isaacson 

作者机构：Bone & Joint Research Laboratory Department of Veterans Affairs Salt Lake City USA Department of Orthopaedics University of Utah Salt Lake City USA The Henry M. Jackson Foundation for the Advancement of Military Medicine Bethesda USA The Center for Rehabilitation Sciences Research De-partment of Physical Medicine and Rehabilitation Uniformed Services University of Health Sciences Be-thesda USA 

出 版 物：《Advances in Bioscience and Biotechnology》 (生命科学与技术进展（英文）)

年 卷 期：2014年第5卷第4期

页      面：283-293页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Biomaterials Orthopaedics Implant Bone Biofilm 

摘      要：Over the past 200 years, there has been significant advancements in the fields of bioengineering and orthopaedics. Investigators, clinicians and manufactures are learning that the success of implant systems is not limited to a single factor, but a combination of variables that must work in unison to provide stability and high survivorship. Innovations continue to advance these fields and include: biomimetic alterations, three-dimensional, patient-specific reconstructions and novel coatings to mitigate aseptic loosening or other pathologies. However, implant systems continue to fail in clinical practice since they do not adhere to key fundamental principles. Therefore, this article is intended to highlight 5 hallmarks of biomaterials that should be considered during design, surgery, and post-operative rehabilitation.