检索结果-南通市图书馆

Renal denervation as an option for the management of hypertension

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2014年第1期28卷 18-24页

作者： Georgina Radhini Santiapillai Albert Ferro Department of Clinical Pharmacology Cardiovascular DivisionBritish Heart Foundation Centre of Research ExcellenceKing's College London

Hypertension is a multifactorial condition which makes the development of treatment approaches difficult. The vast majority of patients are treated with lifestyle measures either alone or in combination with antihypertensive drugs, and this approach is largely successful in controlling blood pressure. However, for a subgroup of patients, control of blood pressure remains resistant to this approach and therefore the development of new strategies is im- perative. The sympathetic nervous system has been known to be implicated in hypertension for many decades, and evidence from studies in the past has revealed the benefit of reducing sympathetic nerve activity in the control of blood pressure albeit with severe side effects. Recent technological advances have allowed for specific targeting of the renal sympathetic nerves by catheter ablation. The Symplicity HTN-1 and HTN-2 trials have provided strong evidence for renal denervation giving rise to considerable blood pressure reductions in treatment-resistant hyper- tensives and, due to the high incidence of hypertension worldwide, this carries the promise of further reducing the global burden of hypertension and its attendant complications. Here we review the evidence for renal denervation in the management of hypertension.

关键词： hypertension renal denervation blood pressure

When and how does brain-derived neurotrophic factor activate Nrf2 in astrocytes and neurons？

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第5期13卷 803-804页

作者： Tetsuro Ishii Giovanni E.Mann University of Tsukuba Tsukuba Japan School of Cardiovascular Medicine and Sciences King's British Heart Foundation Centre of Excellence Faculty of Life Sciences and Medicine King's College Iondon London UK

Circadian rhythm protects neurons：Although the master clock entrains the whole body rhythm,peripheral tissues also express core clock transcription factors Clock and Bmal1,which regulate expression of clock genes including Period（Per）and Cryptochrome（Cry）*** of Per and Cry proteins repress Bmal1-and Clock-mediated transcription forming a negative feedback loop,which regulates nearly a 24 hours self-sustained rhythm including energy metabolism.

关键词： When and how does brain-derived neurotrophic factor activate Nrf2 in astrocytes and neurons NGF

Ageing and Brugada syndrome: considerations and recommendations

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2013年第1期10卷 75-81页

作者： Pieter G. Postema Hanno L Tan Arthur AM Wilde Department of Cardiology Heart Center Academic Medical Center University of Amsterdam P.O. box 22660 1100 DD Amsterdam The Netherlands Princess Al-Jawhara Al-Brahim centre of excellence in Research of Hereditary Disorders Jeddah Kingdom of Saudi Arabia

Brugada syndrome is an inherited disease associated with an increased risk of lethal ventricular arrhythmias. Such arrhythmias stem from innate disruptions in cardiac electrophysiology. Typically, such arrhythmias occur in the third or fourth decade of life. However, Brugada syndrome may also affect geriatric patients. In this paper, we focus on the ageing patientwithBrugada syndrome, and specifically, on the interaction between Brugada syndrome and the more usually acquired clinical problems that may occur with increasing age, such as the use of cardiovascular and non-cardiovascular drugs, or the need for surgery. Such common conditionsmay also disrupt cardiac electrophysiology, thereby conferring added risk for Brugada syndrome patients. We present some considerations and recommendations that may serve as guidance to address these complexities.

关键词： Aging Arrhythmias Brugada syndrome Geriatrics Risk stratification Sudden death

Somatic embryogenesis in wild relatives of cotton (Gossypium Spp.)

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第4期7卷 291-298页

作者： RAO Abdul Qayyum HUSSAIN S. Sarfraz SHAHZAD M. Saqib BOKHARI S. Yassir Abbas RAZA M. Hashim RAKHA Allah MAJEED A. SHAHID A. Ali SALEEM Zafar HUSNAIN Tayyab RIAZUDDIN S. Institution centre of excellence in Molecular Biology University of the Punjab Lahore 53700 Pakistan

Wild cotton species can contribute a valuable gene pool for agronomically desirable cultivated tetraploid cultivars. In order to exploit diploid cotton a regeneration system is required to achieve transformation based goals. The present studies aimed at optimizing the conditions for regeneration of local varieties as well as wild species of cotton. Different callus induction media were tested with varying concentrations of hormones in which sucrose was used as nutritional source. Different explants (hypo-cotyls, cotyledon, root) were used to check the regeneration of both local cotton plants and wild relatives using T & G medium, BAP medium, CIM medium, EMMS medium, and cell suspension medium. Different stages of embryogenicity such as early torpedo stage, late torpedo stage, heart stage, globular stage and cotyledonary stage were observed in wild relatives of cotton. The results of this study pave the way for establishing future transformation methods.

关键词： Cotton Callus Somatic embryogenic Wild species Cell suspension culture

Gastric emptying, postprandial blood pressure, glycaemia and splanchnic flow in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第20期22卷 4860-4867页

作者： Laurence G Trahair Thomas E Kimber Katerina Flabouris Michael Horowitz Karen L Jones Discipline of Medicine The University of Adelaide NHMRC centre of Research excellence in Translating Nutritional Science to Good Health The University of Adelaide Neurology Unit Royal Adelaide Hospital

AIM: To determine gastric emptying, blood pressure, mesenteric artery blood flow, and blood glucose responses to oral glucose in Parkinson’s ***: Twenty-one subjects (13 M, 8 F; age 64.2 ± 1.6 years) with mild to moderate Parkinson’s disease (Hoehn and Yahr score 1.4 ± 0.1, duration of known disease 6.3 ± 0.9 years) consumed a 75 g glucose drink, labelled with 20 MBq 99mTc-calcium phytate. Gastric emptying was quantified with scintigraphy, blood pressure and heart rate with an automated device, superior mesenteric artery blood flow by Doppler ultrasonography and blood glucose by glucometer for 180 min. Autonomic nerve function was evaluated with cardiovascular reflex tests and upper gastrointestinal symptoms by ***: The mean gastric half-emptying time was 106 ± 9.1 min, gastric emptying was abnormally delayed in 3 subjects (14%). Systolic and diastolic blood pressure fell (P heart rate or mesenteric artery blood flow with gastric emptying. Gastric emptying was related to the score for autonomic nerve function (R = 0.55, P < 0.01). There was an inverse relationship between the blood glucose at t = 30 min (R = -0.52, P < 0.05), while the blood glucose at t = 180 min was related directly (R = 0.49, P < 0.05), with gastric ***: In mild to moderate Parkinson’s disease, gastric emptying is related to autonomic dysfunction and a determinant of the glycaemic response to oral glucose.

关键词： Gastric emptying Hypotension Parkinson’ s disease Blood pressure Glucose

Gender and tachycardia： independent modulation of platelet reactivity in patients with atrial fibrillation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2016年第3期13卷 202-208页

作者： Nathan EK Procter Jocasta Ball Doan TM Ngo Jeffrey S Isenberg Elaine M Hylek Yuliy Y Chirkov Simon Stewart John D Horowitz Basil Hetzel Institute for Translational Research Queen Elizabeth Hospital University of Adelaide Adelaide Australia National Health and Medical Research Council(HMRC) Centre of Research Excellence to Reduce Inequality in Heart Disease Mary MacKillop Institutefor Health Research Australian Catholic University Melbourne Australia heart Lung Blood and Vascular Medicine Institute Division of Pulmonary Allergy and Critical Care Medicine Department University of Pittsburgh Pitts-burgh Pennsylvania USA Department of Medicine Boston University School of Medicine Boston Massachusetts USA

Background Female patients with atrial fibrillation （AF） experience increased risk of thromboembolism compared to males, an observation that is reflected by its inclusion in the CHA2DS2VASc score. New onset AF （often associated with tachycardia） also confers upon patients increased thromboembolic risk. The mechanisms underlying this risk are uncertain, but new onset AF is associated with profound impairment of platelet nitric oxide （NO） signalling. Given that cardiovascular responses to catecholamines are gender-dependent, and that the presence of tachycardia in new onset AF may represent a response to catecholaminergic stimulation, we explored the potential impact of gender and tachycardia on platelet aggregation and NO signalling. Methods Interactions were sought in 87 AF patients between the extent of adenosine diphosphate （ADP）-induced platelet aggregation, the anti-aggregatory effects of the NO donor, sodium nitroprusside, gender, and admission heart rate. The potential impact of platelet expression of thioredoxin-interacting protein （Txnip） was also evaluated. Results Analysis ofcovariance confLrmed the presence of physiological antagonism between platelet ADP and NO responses [F （1, 74） = 12.212, P 〈 0.01 ], while female sex correlated with impaired NO responses independent of platelet aggregability [F （2, 74） = 8.313, P 〈 0.01]. Admission heart rate correlated directly with platelet aggregation （r = 0.235, P 〈 0.05）, and inversely with NO response （r = -0.331, P 〈 0.01）. Txnip expression varied neither with gender nor with heart rate. Conclusions These results indicate, that gender and heart rate are independent determinants of platelet fimction. Prospective studies of the putative benefit of reversal of tachycardia on restoration of normal platelet function are therefore a priority.

关键词： Atrial fibrillation Gender heart rate Nitric oxide Platelet aggregation

Timing and mode of intervention for patients with left sided valvular heart disease:an individualized approach

在线全文

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2018年第3期1卷 118-128页

作者： Hannah McConkey Zhengang Zhao S.Redwood M.Chen B.D.Prendergast King’s College London British heart Foundation centre of excellence The Rayne InstituteSt.Thomas’Hospital CampusLondonUnited Kingdomand the Department of CardiologyGuy’s and St.Thomas’NHS Foundation TrustLondonUnited Kingdom Department of Cardiology West China HospitalSichuan University

Left sided valvular heart disease poses major impact on life and *** therapy merely palliates chronic severe valve disease and once symptoms or haemodynamic sequelae appear,life expectancy is markedly *** this article,we review the mechanisms of valve pathology,latest evidence in the quest for pharmacological options,means by which to predict deterioration,and standard and novel treatment options.

关键词： markedly sided patients

MSCs derived extracellular vesicles as a therapeutic paragon for neurodegenerative disorders:A viewpoint

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第6期46卷 1435-1438页

作者： YASHVI SHARMA SHARDA RAY SUJATA MOHANTY Stem Cell Facility(DBT-centre of excellence for Stem Cell Research) All India Institute of Medical SciencesNew DelhiIndia Jawaharlal Nehru Medical College KarnatakaIndia

Neurodegenerative disorders are a vicious woe to the public health and *** in their underlying causes,lack of effective biomarkers for their early detection,existence of only supportive therapy,and their ever rising incidence creates an unmatched need for targeted *** Stem Cells(MSCs)have found to be promising candidates for regenerative and remedial therapy in neurodegenerative disorders,however several biological risks and practical issues impede in their translational *** from MSCs are certain Extracellular Vesicles(EVs),which aid in the paracrine action of MSCs and have lately gained the scientific interest for their implacability in diverse set *** cargo is of utmost importance and is being explored in various different diseases like heart diseases,neuronal diseases,respiratory diseases and hepatic *** thereby hold the position of a likely prospective remedial candidate for therapy against neurodegenerative disorders.

关键词： Mesenchymal stem cells Extracellular vesicles Neurodegenerative disorders Cell-free therapy Regeneration

Functional role of anion channels in cardiac diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第3期26卷 265-278页

作者： LuisLHLIU NathanBOZEAT ZMaggieHUANG SunnyYXIANG LindaYE JosephRHUME Center of Biomedical Research excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA

In comparison to cation (K+,Na+,and Ca2+) channels,much less is currentlyknown about the functional role of anion （Cl-） channels in cardiovascular physiol-ogy and *** the past 15 years,various types of Cl-currentshave been recorded in cardiac cells from different species including *** Cl-channels described to date may be encoded by five different Cl-chan-nel genes:the PKA- and PKC-activated cystic fibrosis tansmembrane conduc-tance regulator （CFTR）,the volume-regulated CLC-2 and CIC-3,and the Ca2+-activated CLCA or *** studies using multiple approaches toexamine the functional role of Cl-channels in the context of health and diseasehave demonstrated that Cl-channels might contribute to:1) arrhythmogenesis inmyocardial injury;2) cardiac ischemic preconditioning;and 3) the adaptive re-modeling of the heart during myocardial hypertrophy and heart ***,anion channels represent very attractive novel targets for therapeutic approachesto the treatment of heart *** evidence suggests that Cl-channels,like cation channels,might function as a multiprotein complex or functional *** the post-genome era,the emergence of functional proteomics has necessitateda new paradigm shift to the structural and functional assessment of integrated Cl-channel multiprotein complexes in the heart,which could provide new insight intoour understanding of the underlying mechanisms responsible for heart diseaseand protection.

关键词： anion channel cardiovascular system physiology heart disease blood pressure