Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

作     者：Rick Xing Ze Lu Milica Radisic 

作者机构：Institute of Biomedical EngineeringUniversity of TorontoTorontoONCanada Department of Chemical Engineering and Applied ChemistryUniversity of TorontoTorontoONCanada Toronto General Research InstituteUniversity Health NetworkTorontoONCanada The Heart and Stroke/Richard Lewar Centre of ExcellenceTorontoONCanada 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第9期

页      面：2801-2819页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：Our work funded by the Canadian Institutes of Health Research Foundation Grant FDN-167274 Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant(RGPIN 326982-10) NSERC-CIHR Collaborative Health Research Grant(CHRP 493737-16) MR is supported by Killam Fellowship and Canada Research Chair.R.X.Z.L.was supported by Alexander Graham Bell Canada Graduate Scholarship-Doctoral Award(PGS-D) 

主　　题：Organ-on-a-chip Toxicity Nanoparticles 

摘      要：Despite showing a great promise in the field of nanomedicine,nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental *** those nanoparticles are generated through intentional or unintentional means,the constant exposure to nanomaterials can inevitably lead to unintended consequences based on epidemiological data,yet the current understanding of nanotoxicity is insufficient relative to the rate of their emission in the environment and the lack of predictive platforms that mimic the human *** calls for a development of more physiologically relevant models,which permit the comprehensive and systematic examination of toxic properties of *** the advancement in microfabrication techniques,scientists have shifted their focus on the development of an engineered system that acts as an intermediate between a well-plate system and animal models,known as *** ability of organ-on-a-chip models to recapitulate in vivo like microenvironment and responses offers a new avenue for nanotoxicological *** this review,we aim to provide overview of assessing potential risks of nanoparticle exposure using organ-on-a-chip systems and their potential to delineate biological mechanisms of epidemiological findings.