When and how does brain-derived neurotrophic factor activate Nrf2 in astrocytes and neurons？

作     者：Tetsuro Ishii Giovanni E.Mann 

作者机构：University of Tsukuba Tsukuba Japan School of Cardiovascular Medicine and Sciences King's British Heart Foundation Centre of Excellence Faculty of Life Sciences and Medicine King's College Iondon London UK 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第5期

页      面：803-804页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：support of JSPS KAKENHI Grant Number 21500386 (TI) British Heart Foundation (GEM, FS/15/31298 FS/16/67/32548) 

主　　题：When and how does brain-derived neurotrophic factor activate Nrf2 in astrocytes and neurons NGF 

摘      要：Circadian rhythm protects neurons：Although the master clock entrains the whole body rhythm,peripheral tissues also express core clock transcription factors Clock and Bmal1,which regulate expression of clock genes including Period（Per）and Cryptochrome（Cry）*** of Per and Cry proteins repress Bmal1-and Clock-mediated transcription forming a negative feedback loop,which regulates nearly a 24 hours self-sustained rhythm including energy metabolism.