检索结果-南通市图书馆

Cathepsin C promotes the progression of periapical periodontitis

Science Bulletin 2020年第11期65卷 951-957,M0004页

作者： Wei Yin Ming Dong Dandan Ye Qicheng Liu Shuo Liu Chun Shi Hua Bai Qian Wang Xue Yang Lina Wang Weidong Niu The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine(Ministry of Education) School&Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Biomedical Data Science Geisel School of Medicine at Dartmouth CollegeOne Medical Center DriveLebanonNH 03756USA school of Stomatology Dalian Medical UniversityDalian 116044China Hospital of Stomatology Yiwu CityJinhua 322005China

Although the role of cathepsin C (Cat C) in inflammation is gradually being elucidated, its function in periapical periodontitis, which is one of the most common infectious diseases worldwide, has not been studied. This study evaluated a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) knock-down (KD) mice, which was constructed with a tetracycline operator, to evaluate the role of Cat C in the pathogenesis and progression of periapical periodontitis. Our results showed, for the first time, that there was a statistically significant increase in the expression of Cat C as periapical periodontitis progressed;this increase started from 1 week after surgery and reached a peak at 3 weeks after surgery, before gradually decreasing. The volume of periapical bone resorption in Cat C KD mice was significantly smaller than that in wild-type mice at 3 and 4 weeks after surgery (P<0.05). Inflammatory cell infiltration into the apical tissues of wild-type mice was also significantly higher than that of Cat C KD mice. The expression of receptor activator of nuclear factor-j B ligand (RANKL) in wild-type mice was also higher than that in Cat C KD mice. The difference in the number of osteoclasts in the apical area between the two groups was statistically significant after 2 weeks. Correlation analysis showed that there was a significant correlation between Cat C and RANKL expression (r= 0.835). Therefore, our data indicated that Cat C promoted the apical inflammation and bone destruction in mice.

关键词： Cathepsin C Receptor activator of nuclear factor-B ligand Periapical periodontitis Tartrate resistant acid phosphatase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gene expression changes in blood RNA after swimming in a chlorinated pool

引用

Journal of Environmental Sciences 2017年第8期29卷 250-261页

作者： Lucas A.Salas Laia Font-Ribera Mariona Bustamante Lauro Sumoy Joan O.Grimalt Sarah Bonnin Maria Aguilar Heidi Mattlin Manuela Hummel Anna Ferrer Manolis Kogevinas Cristina M.Villanueva ISGlobal Centre for Research in Environmental Epidemiology(CREAL)Barcelona Spain Department of Epiderniology The Geisel School of Medicine at Dartmouth Lebanon NH USA Universitat Pompeu Fabra (UPF) Barcelona Spain CIBER Epiclemiologia y Salud Publica (CIBERESP) Barcelona Spain IMIM (Hospital del Mar medical Research Institute) Barcelona Spain Genomics and Disease Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology Barcelona Spain Genomics Core Facility Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology Barcelona Spain Institute of Predictive and Personalized medicine of Cancer (IMPPC) Institut Germans Trias i Pujol (IGTP) Can Ruti Campus Badalona Spain Department of Environmental Chemistry Institute of Environmental Assessment and Water Research (CSIC) Barcelona Spain

Exposure to disinfection by-products（DBP） such as trihalomethanes（THM） in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes in blood gene expression of adult recreational swimmers after swimming in a chlorinated pool. Volunteers swam 40 min in an indoor chlorinated pool. Blood samples were drawn and four THM（chloroform,bromodichloromethane, dibromochloromethane and bromoform） were measured in exhaled breath before and after swimming. Intensity of physical activity was measured as metabolic equivalents（METs）. Gene expression in whole blood m RNA was evaluated using Illumina Human HT-12v3 Expression-Bead Chip. Linear mixed models were used to evaluate the relationship between gene expression changes and THM exposure. Thirty-seven before-after pairs were analyzed. The median increase from baseline to after swimming were： 0.7 to 2.3 for MET, and 1.4 to 7.1 μg/m^3 for exhaled total THM（sum of the four THM）.Exhaled THM increased on average 0.94 μg/m^3 per 1 MET. While 1643 probes were differentially expressed post-exposure. Of them, 189 were also associated with exhaled levels of individual/total THM or MET after False Discovery Rate. The observed associations with the exhaled THM were low to moderate（Log-fold change range：-0.17 to 0.15）. In conclusion, we identified short-term gene expression changes associated with swimming in a pool that were minor in magnitude and their biological meaning was unspecific. The high collinearity between exhaled THM levels and intensity of physical activity precluded mutually adjusted models with both covariates. These exploratory results should be validated in future studies.

关键词： Trihalomethanes Disinfection by-products Gene expression Swimming pools Metabolic rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gene signatures associated with genomic aberrations predict prognosis in neuroblastoma

引用

Cancer Communications 2020年第2期40卷 105-118页

作者： Xiaoyan He Chao Qin Yanding Zhao Lin Zou Hui Zhao Chao Cheng Center for Clinical Molecular medicine Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of PediatricsChildren’s Hospital of Chongqing Medical UniversityChongqing 400014P.R.China Beijing Key Lab of Traffic Data Analysis and Mining School of Computer and Information TechnologyBeijing Jiaotong UniversityBeijing 100044P.R.China Department of Biomedical Data Science Geisel School of Medicine at DartmouthLebanonNH 03766USA school of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077P.R.China Department of medicine Baylor College of MedicineHoustonTX 77030USA Institute for Clinical and Translational Research Baylor College of MedicineHoustonTX 77030USA

Background:Neuroblastoma(NB)is a heterogeneous disease with respect to genomic abnormalities and clinical *** recent advances in our understanding of the association between the genetic aberrations and clinical features,it remains one of the major challenges to predict prognosis and stratify patients for determining personalized therapy in this *** aim of this study was to develop an effective prognosis prediction model for NB ***:We integrated diverse computational analyses to define gene signatures that reflect MYCN activity and chromosomal aberrations including deletion of chromosome 1p(Chr1p_del)and chromosome 11q(Chr11q_del)as well as chromosome 11q whole loss(Chr11q_wls).We evaluated the prognostic and predictive values of these signatures in seven NB gene expression datasets(the number of samples ranges from 94 to 498,with a total of 2120)generated from both RNA sequencing and microarray ***:MYCN signature was a more effective prognostic marker than MYCN amplification status and MYCN ***,the Chr1p_del score was more prognostic than Chr1p *** activity scores of MYCN,Chr1p_del and Chr11q_del were associated with poor prognosis,while the Chr11q_wls score was linked to good *** integrated the activity scores of MYCN,Chr1p_del,Chr11q_del,and Chr11q_wls and clinical variables into an integrative prognostic model,which displayed significant performance over the clinical variables or each genomic aberration ***:Our integrative gene signature model shows a significantly improved forecast performance with prognostic and predictive information,and thereby can be served as a biomarker to stratify NB patients for prognosis evaluation and surveillance programs.

关键词： chromosome aberration gene expression profile MYCN gene neuroblastoma prognosis survival analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Social Activity Patterns Drive High Rates of Latent Tuberculosis Infection among Adolescents in Urban Tanzania<br/>—Latent TB Infection in Adolescents, Tanzania

引用

Journal of Tuberculosis Research 2018年第1期6卷 81-95页

作者： Isaac I. Maro Keiko Nakamura Kaoruko Seino Kisali Pallangyo Patricia Munseri Mecky Matee Charles Fordham von Reyn Department of Global Health Entrepreneurship Tokyo Medical and Dental University Tokyo Japan Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania Department of Internal medicine Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania Department of Microbiology and Immunology School of Medicine Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania geisel school of medicine at dartmouth Hanover NH USA

SETTING: Dar es Salaam, Tanzania. OBJECTIVE: To determine the prevalence of latent tuberculosis (TB) infection (LTBI) among adolescents in a country with a high TB burden, and examine risks of LTBI according to their social activity patterns. METHODS: A cross-sectional study nested within a phase 2b randomised, placebo controlled, double blind study and consisted of 824 adolescents, 13 - 15 years old who had received Bacillus Calmette-Guérin (BCG) vaccine, were attending public secondary schools and had no evidence of active tuberculosis (TB). Anthropometric measurements were obtained, a questionnaire administered, and phlebotomy performed for a T spot interferon-γ?release assay (IGRA) to detect LTBI. RESULTS: Among 824 subjects, 149 (18%) had a positive IGRA. After adjusting for the influence of household socioeconomic status, history of TB contact, living environment and nutritional status, LTBI risk was higher in subjects with than without regular informal encounters with traditional alcoholic beverage drinkers (AOR, 6.37 [1.84 - 22.00]). Other significant factors for LTBI risk included contact with TB patient at school (AOR, 3.34 [1.14 - 9.80]), and living close to a health facility, as was observed among those from houses within a 10 - 30-minute walking distance to the nearest health facility, who were less likely to be IGRA-positive than those who were living within a 10-minute walking distance (AOR, 0.30 [95%CI, 0.13 - 0.69]). CONCLUSION: This IGRA study revealed a high prevalence of LTBI among adolescents in Dar es Salaam, Tanzania with prior BCG immunization. Informal social encounters were identified as independent risk factors for LTBI, along with a history of contact with TB patients, living environment characteristics and household socioeconomic status. Efforts focusing on risk of MTB transmission in adolescents at informal social gatherings will improve interventions to reduce LTBI in this population and consequently the subsequent risk of developing a

关键词： Dar es Salaam Social Factors IGRA T Spot Adolescents BCG DAR 901

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pancreatic cancer survival trends in the US from 2001 to 2014:a CONCORD-3 study

引用

Cancer Communications 2023年第1期43卷 87-99页

作者： Maja Nikšić Pamela Minicozzi Hannah K Weir Heather Zimmerman Maria J Schymura Judith R Rees Michel P Coleman Claudia Allemani 无 Cancer Survival Group Department of Non-Communicable Disease EpidemiologyLondon School of Hygiene&Tropical MedicineKeppel StreetLondon WC1E 7HTUK Centre for Health Services Studies University of KentCanterbury CT27NFUK Division of Cancer Prevention and Control Centers for Disease Control and PreventionAtlantaGA 30333USA Montana Central Tumor Registry Chronic Disease Prevention and Health Promotion BureauPO Box 2029511400 BroadwayHelenaMT 59620-2951USA Bureau of Cancer Epidemiology New York State Cancer RegistryNew York State Department of Health150 BroadwayAlbanyNY 12204-2719USA New Hampshire State Cancer Registry Norris Cotton Cancer Centerand Department of EpidemiologyGeisel School of MedicineDartmouth CollegeDartmouth-Hitchcock Medical CenterOne Medical Center DriveLebanonNH 03756USA Cancer Division University College London Hospitals NHS Foundation Trust250 Euston RoadLondon NW12PGUK US CONCORDWorking Group

Background:Survival from pancreatic cancer is low *** the US,the 5-year relative survival has been slightly higher for women,whites and younger patients than for their counterparts,and differences in age and stage at diagnosis[Corrections added Nov 16,2022,after first online publication:a new affiliation is added to Maja Nikšić]may contribute to this *** aimed to examine trends in survival by race,stage,age and sex for adults(15-99 years)diagnosed with pancreatic cancer in the ***:This population-based study included 399,427 adults registered with pancreatic cancer in 41 US state cancer registries during 2001-2014,with followup to December 31,*** estimated age-specific and age-standardized net survival at 1 and 5 ***:Overall,12.3%of patients were blacks,and 84.2%were *** 9.5%of patients were diagnosed with localized disease,but 50.5%were diagnosed at an advanced stage;slightly more among blacks,mainly among *** substantial changes were seen over time(2001-2003,2004-2008,2009-2014).In general,1-year net survival was higher in whites than in blacks(26.1%vs.22.1%during 2001-2003,35.1%vs.31.4%during 2009-2014).This difference was particularly evident among patients with localized disease(49.6%in whites vs.44.6%in blacks during 2001-2003,60.1%vs.55.3%during 2009-2014).The survival gap between blacks and whites with localized disease was persistent at 5 years after diagnosis,and it widened over time(from 24.0%vs.21.3%during 2001-2003 to 39.7%vs.31.0%during 2009-2014).The survival gap was wider among men than among ***:Gaps in 1-and 5-year survival between blacks and whites were persistent throughout 2001-2014,especially for patients diagnosed with a localized tumor,for which surgery is currently the only treatment modality with the potential for cure.

关键词： pancreatic cancer race/ethnicity stage net survival population-based cancer registries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

INTEGRATION OF A LONGITUDINAL CURRICULUM IN medical ACUPUNCTURE WITH RESIDENCY TRAINING IN FAMILY medicine

引用

Journal of Integrative medicine 2014年第3期 314-315页

作者： Richard Hobbs Maine-dartmouth Family medicine Residency

Objective: To demonstrate that a residency-based model for training physicians in acupuncture is feasible and results in competence, as measured by the certification process of the American Board of medical ***: The Maine-dartmouth Family medicine Residency, which is affiliated with the geisel school of medicine at dartmouth College, has for the past five years required all residents to participate in a 300-hour integrative medicine curriculum, as part of a pilot project developed at the University of Arizona Integrative medicine *** the beginning, an introduction to medical acupuncture has been offered as an approved elective in the integrative medicine *** 2010, a three-year, elective, longitudinal curriculum in medical acupuncture was developed and approved by the Curriculum Committee of the residency *** curriculum was also presented to the American Board of medical Acupuncture and was accepted as an alternative route for satisfying board *** of the Mainedartmouth longitudinal curriculum include:(a) principles oftraditional Chinese medicine;(b) development of skills in point location, needling, cupping and moxibustion;(c) modern paradigms, including electroacupuncture, French energetics, neuroanatomical approaches, balance methods and microsystems;(d) classical diagnostic methods;(e) reiterative instruction in differentiation of syndromes and treatment planning;(f) Chinese dietary therapy, Tuina, Qigong and other treatment modalities;(g) clinical ***: In 2013, the first resident to complete the program passed the certification examination of the American Board of medical ***: Benefits of acupuncture training during residency include:(a) a reiterative process as opposed to linear learning;(b) enhanced opportunities for supervised clinical practice as part of acupuncture training;(c) preparation for seamless integration of acupuncture into a primary care practice.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Sessile serrated adenomas in the proximal colon are likely to be flat,large and occur in smokers

引用

World Journal of Gastroenterology 2013年第32期19卷 5271-5277页

作者： Tarun Rustagi Priya Rangasamy Matthew Myers Melinda Sanders Haleh Vaziri George Y Wu John W Birk Petr Protiva Joseph C Anderson Section of Digestive Diseases Department of Internal MedicineYale University School of MedicineNew HavenCT 06520United States Department of Gastroenterology University of Connecticut Health CenterFarmingtonCT 06032United States Department of Pathology University of Connecticut Health CenterFarmingtonCT 06063United States Department of Gastroenterology VA West HavenYale School of MedicineNew HavenCT 06520United States Department of Gastroenterology VA Medical CenterWindsorVT 05009United States the geisel school of medicine at dartmouth medical HanoverNH 03755United States

AIM:To examine the epidemiology and the morphology of the proximal sessile serrated adenomas(SSAs).METHODS:We conducted a retrospective study to identify patients with SSAs using a university-based hospital pathology database query from January 2007to April *** collected included:age,gender,ethnicity,body mass index,diabetes,smoking,family history of colorectal cancer,aspirin,and statin *** collected data on morphology of SSAs including site(proximal or distal),size,and endoscopic appearance(flat or protuberant).We also compared proximal SSAs to proximal tubular adenomas detected during same time ***:One hundred and twenty patients with SSAs were identified:61%were distal and 39%were proximal *** SSAs were more likely to be flat than distal(100%vs 78%respectively;P=0.0001).Proximal SSAs were more likely to occur in smokers(OR=2.63;95%CI:1.17-5.90;P=0.02)and in patients with family history of colorectal cancer(OR=4.72;95%CI:1.43-15.55;P=0.01)compared to *** SSAs were statistically more likely to be≥6 mm in size(OR=2.94;P=0.008),and also more likely to be large(≥1 cm)(OR=4.55;P=0.0005)compared to the distal *** were more likely to have proximal(P=0.02),flat(P=0.01)and large(P=0.007)SSAs compared to *** to proximal tubular adenomas,proximal SSAs were more likely to be large and occur in ***:Proximal SSAs which accounted for two-fifths of all SSAs were more likely to present as flat lesions,larger SSAs,and were more likely to occur in smokers and in patients with family history of colorectal *** data has implications for colorectal cancer screening.

关键词： Proximal Sessile Serrated Adenoma Colonoscopy Colorectal cancer Smoking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The virtual peripheral nerve academy:education for the identification and treatment of peripheral nerve disorders

引用

Plastic and Aesthetic Research 2022年第1期9卷 707-715页

作者： Erica B.Lee Allison Podsednik Kimberly Khoo Amal Cheema Raysa Cabrejo Chen Shen Joseph Rosen A.Lee Dellon Department of Plastic and Reconstructive Surgery Johns Hopkins School of MedicineMD 89011USA Department of Plastic and Reconstructive Surgery The University of Texas Rio Grande ValleyEdinburgTX 78539USA Department of Plastic and Reconstructive Surgery Geisel School of Medicine at DartmouthHanoverNH 03755USA

Millions of people around the globe suffer peripheral nerve injuries caused by trauma and medical ***,medical school curricula are profoundly deficient in peripheral nerve *** lack of knowledge within the healthcare profession may cause inadequate patient *** developed the Virtual Peripheral Nerve Academy(VPNA)as a reusable virtual learning environment to provide medical students with detailed education on the peripheral nervous system(PNS).Students are introduced to the PNS through virtual 3D rendering of the human body,wherein they visualize individual nerves through dissection and observe normal motor and sensory function associated with each *** structures that are absent from traditional texts are included in this visualization,ranging from the innervation of joints to the normal anatomic variation required for differential diagnosis of pain after an *** modules on peripheral nerve disorders allow students to observe pathophysiological mechanisms,associated symptomatology,and appropriate *** are briefed on a patient clinical case,then interact with a patient avatar to learn the appropriate diagnostics,including physical exam maneuvers and electrodiagnostic *** modules on peripheral nerve surgeries detail surgical *** VPNA data and analytics dashboards allow medical students and course instructors to assess skill improvement and identify specific learning *** built-in learner management system and availability on both computer-based and virtual reality platforms facilitate integration into any existing medical school ***,this immersive technology enables every medical student to learn about the peripheral nervous system and gain competency in treating real-life nerve pathologies.

关键词： Virtual reality peripheral nervous system nerve surgical education medical education simulation plastic surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

患者参与医疗卫生服务共建:质量改善的关键

引用

英国医学杂志中文版 2019年第10期22卷 594-597页

作者： Paul Batalden 史黎炜(译) 赵羽西(译) 肖月(审校) dartmouth Institute for Health Policy and Clinical Practice Geisel Medical SchoolDartmouth CollegeNew Hampshire 国家卫生健康委卫生发展研究中心

仅仅关注医疗卫生的服务或产品特性的分析,往往会忽视医患关系这个核心要素。Paul Batalden分享了十年来的研究结果,提出优化提升卫生体系绩效的建议。临床医生治疗患者时都曾有过“心有余而力不足”之感1.卫生体系往往存在一些不尽如... 详细信息

仅仅关注医疗卫生的服务或产品特性的分析,往往会忽视医患关系这个核心要素。Paul Batalden分享了十年来的研究结果,提出优化提升卫生体系绩效的建议。临床医生治疗患者时都曾有过“心有余而力不足”之感1.卫生体系往往存在一些不尽如人意之处,由于行政工作压力的增加,占用了医生较多的临床工作时间,从而影响了患者健康结果。

关键词：医患关系临床医生卫生体系患者参与医疗卫生质量改善产品特性优化提升

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

B cell infiltration is highly associated with prognosis and an immune-infiltrated tumor microenvironment in neuroblastoma

引用

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 466-477页

作者： Evelien Schaafsma Chongming Jiang Chao Cheng Department of Molecular and Systems Biology Dartmouth CollegeHanoverNH 03755USA Department of Biomedical Data Science Geisel School of Medicine at DartmouthLebanonNH 03756USA Department of medicine Baylor College of MedicineHoustonTX 77030USA Dan L Duncan Comprehensive Cancer Center Baylor College of MedicineHoustonTX 77030USA The Institute for Clinical and Translational Research Baylor College of MedicineHouston TX77030USA.

Aim:Neuroblastoma is the most common extracranial solid tumor in *** advances in immunotherapy Approaches,including in neuroblastoma,have shown the important role of the immune system in mounting an effective anti-tumor *** this study,we aimed to provide a comprehensive investigation of immune cell infiltration in neuroblastoma utilizing a large number of gene expression ***:We inferred immune cell infiltration using an established immune inference method and evaluated the association between immune cell abundance and patient prognosis as well as common chromosomal abnormalities found in *** addition,we evaluated co-infiltration patterns among distinct immune cell ***:The infiltration of naïve B cells,NK cells,and CD8+T cells was associated with improved patient ***ïve B cells were the most consistent indicator of prognosis and associated with an active immune tumor *** with high B cell infiltration showed high co-infiltration of other immune cell types and the enrichment of immune-related *** presence of high B cell infiltration was associated with both recurrence-free and overall survival,even after adjusting for clinical ***:In this study,we have provided a comprehensive evaluation of immune cell infiltration in neuroblastoma using gene expression *** propose an important role for B cells in the neuroblastoma tumor microenvironment and suggest that B cells can be used as a prognostic biomarker to predict recurrence-free and overall survival independently of currently utilized prognostic variables.

关键词： Neuroblastoma immune cell infiltration prognosis MYCN amplification B cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：