B cell infiltration is highly associated with prognosis and an immune-infiltrated tumor microenvironment in neuroblastoma
作者机构：Department of Molecular and Systems BiologyDartmouth CollegeHanoverNH 03755USA Department of Biomedical Data ScienceGeisel School of Medicine at DartmouthLebanonNH 03756USA Department of MedicineBaylor College of MedicineHoustonTX 77030USA Dan L Duncan Comprehensive Cancer CenterBaylor College of MedicineHoustonTX 77030USA The Institute for Clinical and Translational ResearchBaylor College of MedicineHouston TX77030USA.
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2021年第7卷第1期
页 面：466-477页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the Cancer Prevention Research Institute of Texas(CPRIT)(RR180061 to Cheng C) the National Cancer Institute of the National Institutes of Health(1R21CA227996 to Cheng C) the T32 training grant of the National Institutes of Health(T32 AI007363 to Schaafsma E).Cheng C is a CPRIT Scholar in Cancer Research
主 题：Neuroblastoma immune cell infiltration prognosis MYCN amplification B cells
摘 要：Aim:Neuroblastoma is the most common extracranial solid tumor in *** advances in immunotherapy Approaches,including in neuroblastoma,have shown the important role of the immune system in mounting an effective anti-tumor *** this study,we aimed to provide a comprehensive investigation of immune cell infiltration in neuroblastoma utilizing a large number of gene expression ***:We inferred immune cell infiltration using an established immune inference method and evaluated the association between immune cell abundance and patient prognosis as well as common chromosomal abnormalities found in *** addition,we evaluated co-infiltration patterns among distinct immune cell ***:The infiltration of naïve B cells,NK cells,and CD8+T cells was associated with improved patient ***ïve B cells were the most consistent indicator of prognosis and associated with an active immune tumor *** with high B cell infiltration showed high co-infiltration of other immune cell types and the enrichment of immune-related *** presence of high B cell infiltration was associated with both recurrence-free and overall survival,even after adjusting for clinical ***:In this study,we have provided a comprehensive evaluation of immune cell infiltration in neuroblastoma using gene expression *** propose an important role for B cells in the neuroblastoma tumor microenvironment and suggest that B cells can be used as a prognostic biomarker to predict recurrence-free and overall survival independently of currently utilized prognostic variables.
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