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Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures

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Neuroscience Bulletin 2022年第11期38卷 1347-1364页

作者： Jie Yu Yao Cheng Yaru Cui Yujie Zhai Wenshen Zhang Mengdi Zhang Wenyu Xin Jia Liang Xiaohong Pan Qiaoyun Wang Hongliu Sun School of Pharmaceutical Sciences Binzhou Medical UniversityYantai 264003China the sixth scientifc research department Shandong Institute of Nonmetallic MaterialsJinan 250031China

An increased level of reactive oxygen species is a key factor in neuronal apoptosis and epileptic *** reportedly attenuates the apoptosis and injury induced by oxidative ***,we evaluated the effects of exogenous irisin in a kainic acid(KA)-induced chronic spontaneous epilepsy rat *** results indicated that exogenous irisin significantly attenuated the KA-induced neuronal injury,learning and memory defects,and *** treatment also increased the levels of brain-derived neurotrophic factor(BDNF)and uncoupling protein 2(UCP2),which were initially reduced following KA ***,the specific inhibitor of UCP2(genipin)was administered to evaluate the possible protective mechanism of *** reduced apoptosis,neurodegeneration,and spontaneous seizures in rats treated with irisin were significantly reversed by genipin *** findings indicated that neuronal injury in KA-induced chronic epilepsy might be related to reduced levels of BDNF and ***,our results confirmed the inhibition of neuronal injury and epileptic seizures by exogenous *** protective effects of irisin may be mediated through the BDNF-mediated UCP2 *** results thus highlight irisin as a valuable therapeutic strategy against neuronal injury and epileptic seizures.

关键词： Epilepsy Seizure Irisin Genipin Neuronal injury

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

Optical and Microstructural Characterisations of Pulsed rf Magnetron Sputtered Alumina Thin Film

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Journal of Materials Science & Technology 2013年第10期29卷 929-936页

作者： I.Neelakanta Reddy V.Rajagopal Reddy N.Sridhara S.Basavaraja A.K.Sharma Arjun Dey Thermal Systems Group ISRO Satellite CentreVimanapura Post department of Physics Sri Venkateswara University Bruker India Nanotechnology Laboratory Jawaharlal Nehru Centre for Advanced Scientifc Research (JNCASR)

Alumina thin films were deposited on fused quartz and SS304 substrate by pulsed rf magnetron sputtering with both direct and reactive methods. The films were characterised by energy dispersive X-ray spectroscopy, X-ray diffraction, scanning electron microscopy, field emission scanning electron microscopy and atomic force microscopy to reveal the microstructure, surface morphology and topography of thin films. Transmittance and reflectance of alumina thin film were evaluated after deposition on the quartz substrate. Transmittance of the quartz remains almost un-altered when alumina was deposited by the reactive sputtering. A marginal decrease of ~4% in the transmittance of quartz was, however, observed after deposition of alumina by direct sputtering. Infrared emittance of the substrate also remains almost constant after deposition of thin alumina film. Further, as-deposited alumina on SS304 obtained by both direct and reactive sputtering process was amorphous in nature. However, after annealing crystalline peaks were observed.

关键词： Alumina Thin film rf magnetron sputtering Microstructure Transmittance Reflectance Infrared emissivity

A Multi-physics Methodology for Four States of Matter

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Communications on Applied Mathematics and Computation 2020年第3期2卷 487-514页

作者： Louisa Michael Stephen T.Millmore Nikolaos Nikiforakis Laboratory for scientifc Computing Cavendish LaboratoryDepartment of PhysicsUniversity of CambridgeCambridgeUK

We propose a numerical methodology for the simultaneous numerical simulation of four states of matter:gas,liquid,elastoplastic solids,and *** distinct,interacting physical processes are described by a combination of compressible,inert,and reactive forms of the Euler equations,multi-phase equations,elastoplastic equations,and resistive MHD *** of systems of equations are usually solved by coupling finite element for solid modelling and CFD models for fluid modelling or including material effects through boundary conditions rather than full material *** simultaneous solution methodology lies on the recasting of all the equations in the same,hyperbolic form allowing their solution on the same grid with the same finite volume numerical *** use a combination of sharp-and diffuse-interface methods to track or capture material interfaces,depending on the *** communication between the distinct systems of equations(i.e.,materials separated by sharp interfaces)is facilitated by means of mixed-material Riemann solvers at the boundaries of the systems,which represent physical material *** this end,we derive approximate mixed-material Riemann solvers for each pair of the above models based on characteristic *** demonstrate the applicability of the new methodology,we consider a case study,where we investigate the possibility of ignition of a combustible gas that lies over a liquid in a metal container that is struck by a plasma arc akin to a lightning *** study the effect of the metal container material and its conductivity on the ignition of the combustible gas,as well as the effects of an additional dielectric coating,the sensitivity of the gas,and differences between scenarios with sealed and pre-damaged metal surfaces.

关键词： Plasma modelling Four states of matter Lightning Ignition Combustible gas Elastoplastic solids

Risk factors for chronic ankle instability after first episode of lateral ankle sprain:A retrospective analysis of 362 cases

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Journal of Sport and Health Science 2023年第5期12卷 606-612页

作者： Jieyuan Zhang Kai Yang Cheng Wang Wenqi Gu Xueqian Li Shaoling Fu Guoxun Song Jiazheng Wang Chenglin Wu Hongyi Zhu Zhongmin Shi National Center for Orthopaedics Shanghai Sixth People’s HospitalShanghai 200233China department of Orthopedic Surgery Shanghai Sixth People’s HospitalShanghai 200233China department of Radiology Shanghai Sixth People’s HospitalShanghai 200233China Institute of Clinical research National Center for OrthopaedicsShanghai Sixth People’s HospitalShanghai 200233China

Background:Chronic ankle instability(CAI) is a common sequela following an acute lateral ankle sprain(LAS).To treat an acture LAS more effectively and efficiently,it is important to identify patients at substantial risk for developing *** study identifies magnetic resonance imaging(MRI) manifestations for predicting CAI development after a first episode of LAS and explores appropriate clinical indications for ordering MRI scans for these ***:All patients with a first-episode LAS who received plain radiograph and MRI scanning within the first 2 weeks after LAS from December 1,2017 to December 1,2019 were *** were collected using the Cumberland Ankle Instability Tool at final *** and other related clinical variables,including age,sex,body mass index,and treatment were also *** and multivariable analyses were performed successively to identify risk factors for CAI after first-episode ***:A total 131 out of 362 patients with a mean follow-up of 3.0± 0.6 years(mean ± SD;2.0—4.1 years) developed CAI after first-episode *** to multivariable regression,development of CAI after first-episode LAS was associated with 5 prognostic factors:age(odds ratio(OR)=0.96,95% confidence interval(95%CI):0.93-1.00,p=0.032);body mass index(OR=1.09,95%CI:1.02-1.17,p=0.009);posterior talofibular ligament injury(OR=2.17,95%CI:1.05-4.48,p=0.035);large bone marrow lesion of the talus(OR=2.69,95%CI:1.30-5.58,p=0.008),and Grade 2 effusion of the tibiotalar joint(OR=2.61,95%CI:1.39-4.89,p=0.003).When patients had at least 1 positive clinical finding in the 10-m walk test,anterior drawer test,or inversion tilt test,they had a 90.2% sensitivity and 77.4% specificity in terms of detecting at least 1 prognostic factor by ***:MRI scanning is valuable in predicting CAI after first-episode LAS for those patients with at least 1 positive clinical finding in the10-m walk test,anterior drawer test,and inversion tilt

关键词： Chronic ankle instability Lateral ankle sprain MRI Risk factorsTagedAPTARAEnd

Observation of the Emission Spectra of an Atmospheric Pressure Radio-frequency Plasma Jet

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Plasma Science and Technology 2005年第5期7卷 3045-3047页

作者：王百荣朱文超蒲以康 Chemical Defence Institute The sixth department of research Institute of Chemical Defence department of Engineering Physics Tsinghua University Beijing 100084 China

An atmospheric pressure plasma jet （APPJ） using radio-frequency （13.56 MHz） power has been developed to produce homogeneous glow discharge at low temperature. With optical emission spectroscopy, we observed the excited species （atomic helium, atomic oxygen and metastable oxygen） generated in this APPJ and their dependence on gas composition ratio and RF power. O and O2（b1∑g^＋） are found in the effluent outside the jet by measuring the emission spectra of effluent perpendicular to the jet. An interesting phenomenon is found that there is an abnormal increase of O emission intensity （777.4 nm） between 10 mm and 40 mm away from the nozzle. This observation result is very helpful in practical operation.

关键词： low temperature plasma atmospheric pressure plasma jet optical emissionspectroscopy

Role of combined propofol and sufentanil anesthesia in endoscopic injection sclerotherapy for esophageal varices

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World Journal of Gastroenterology 2017年第44期23卷 7875-7880页

作者： Yang Yu Sheng-Lin Qi Yong Zhang department of Anesthesiology the Sixth People’s Hospital of Dalian Endoscopy Center the Sixth People’s Hospital of Dalian President Office the Sixth People’s Hospital of Dalian

AIM To investigate the efficacy and safety of a combination of sufentanil and propofol injection in patients undergoing endoscopic injection sclerotherapy(EIS) for esophageal varices(EVs). METHODS Patients with severe EVs who underwent EIS with sufentanil and propofol anesthesia between April 2016 and July 2016 at our hospital were reviewed. Although EIS and sequential therapy were performed under endotracheal intubation, we only evaluated the efficacy and safety of anesthesia for the first EIS procedure. Patients were intravenously treated with 0.5-1 μg/kg sufentanil. Anesthesia was induced with 1-2 mg/kg propofol and maintained using 2-5 mg/kg per hour of propofol. Information, regarding age, sex, weight, American Association of Anesthesiologists(ASA) physical status, Child-Turcotte-Pugh(CTP) classification, indications, preanesthetic problems, endoscopic procedure, successful completion of the procedure, anesthesia time, recovery time, and anesthetic agents, was recorded. Adverse events, including hypotension, hypertension, bradycardia, and hypoxia, were also *** Propofol and sufentanil anesthesia was provided in 182 procedures involving 140 men and 42 women aged 56.1± 11.7 years(range, 25-83 years). The patients weighed 71.4 ± 10.7 kg(range, 45-95 kg) and had ASA physical status classifications of Ⅱ(79 patients) or Ⅲ(103 patients). Ninety-five patients had a CTP classification of A and 87 had a CTP classification of B. Intravenous anesthesia was successful in all cases. The mean anesthesia time was 33.1 ± 5.8 min. The mean recovery time was 12.3 ± 3.7 min. Hypotension occurred in two patients(1.1%, 2/182). No patient showed hypertension during the endoscopic therapy procedure. Bradycardia occurred in one patient(0.5%, 1/182), and hypoxia occurred in one patient(0.5%, 1/182). All complications were easily treated with no adverse sequelae. All endoscopic procedures were completed *** The combined use of propofol and sufentanil injecti

关键词： Endoscopic injection Esophageal varices Propofol Sclerotherapy Sufentanil

Application of metabolomics in clinical and laboratory gastrointestinal oncology

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 536-549页

作者： Peng Gao Xin Huang Xue-Yan Fang Hui Zheng Shu-Ling Cai Ai-Jun Sun Liang Zhao Yong Zhang department ofClinical Laboratory Dalian Sixth People's HospitalDalian 116031Liaoning ProvinceChina department of Internal Medicine Dalian Sixth People's HospitalDalian 116031Liaoning ProvinceChina department of Nursing Dalian Sixth People's HospitalDalian 116031Liaoning ProvinceChina Clinical research Center Dalian Sixth People's HospitalDalian 116031Liaoning ProvinceChina department of Surgery Dalian Sixth People's HospitalDalian 116031Liaoning ProvinceChina

Metabolites are versatile bioactive *** are not only the substrates and/or the products of enzymatic reactions but also act as the regulators in the systemic *** is a high-throughput analytical strategy to qualify or quantify as many metabolites as possible in the *** is an indispensable part of systems *** leading techniques in this field are mainly based on mass spectrometry and nuclear magnetic resonance *** metabolomic analysis has gained wide use in bioscience *** the tumor research arena,metabolomics can be employed to identify biomarkers for prediction,diagnosis,and *** effect evaluation and personalized medicine decision-making can also benefit from metabolomic analysis of patient biofluid or biopsy *** cell-level studies can help in disease *** this review,the basic features and principles of varied metabolomic analysis are *** value of metabolomics in clinical and laboratory gastrointestinal cancer studies is discussed,especially for mass spectrometry ***,combined use of metabolomics and other tools to solve problems in cancer practice is briefly *** summary,metabolomics paves a new way to explore cancerous diseases in the light of small molecules.

关键词： Metabolomics Biomarker Mass spectrometry Metabolite Gastrointestinal cancer Diagnosis