Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures
作者机构：School of Pharmaceutical SciencesBinzhou Medical UniversityYantai 264003China The Sixth Scientifc Research DepartmentShandong Institute of Nonmetallic MaterialsJinan 250031China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2022年第38卷第11期
页 面：1347-1364页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：the National Natural Science Foundation of China(81573412 and 81803546) Key Research and Development Plan of Shandong Province(2018GSF121004) Yantai Science and Technology Development Plan(2019xdhz098)
主 题：Epilepsy Seizure Irisin Genipin Neuronal injury
摘 要：An increased level of reactive oxygen species is a key factor in neuronal apoptosis and epileptic *** reportedly attenuates the apoptosis and injury induced by oxidative ***,we evaluated the effects of exogenous irisin in a kainic acid(KA)-induced chronic spontaneous epilepsy rat *** results indicated that exogenous irisin significantly attenuated the KA-induced neuronal injury,learning and memory defects,and *** treatment also increased the levels of brain-derived neurotrophic factor(BDNF)and uncoupling protein 2(UCP2),which were initially reduced following KA ***,the specific inhibitor of UCP2(genipin)was administered to evaluate the possible protective mechanism of *** reduced apoptosis,neurodegeneration,and spontaneous seizures in rats treated with irisin were significantly reversed by genipin *** findings indicated that neuronal injury in KA-induced chronic epilepsy might be related to reduced levels of BDNF and ***,our results confirmed the inhibition of neuronal injury and epileptic seizures by exogenous *** protective effects of irisin may be mediated through the BDNF-mediated UCP2 *** results thus highlight irisin as a valuable therapeutic strategy against neuronal injury and epileptic seizures.
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