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Chinese Chemical Letters 2022年第9期33卷 4203-4207页

作者： Ying He Mengjia Liu Shun Teng Lukasz Wojtas Guangxin Gu Xiaodong Shi Department of Chemistry University of South FloridaTampaFL 33620United States Department of Materials Science Fudan UniversityShanghai 200438China

Fluorescence(FL)active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G_(8)-*** p-cyano(p-CN)and 8-anthracene(8-An)substituted guanosines were identified to give the strongest fluorescence with the formation of G_(8)-octamers(G_(8))both in solution(NMR)and solid state(X-ray).This well-defined G_(8)-octamer system has provided the first direct evidence on the self-assembled G-quadruplex fluorescence emission with aggregation-induced emission(AIE),which could be applied as the foundation for FL molecular probe design toward G-quadruplex recognition.

关键词： Self-assembly H-bonding G_(4)-quartet Fluorescence Aggregation induced emission

Mapping Tree Species Using Advanced Remote Sensing Technologies: A State-of-the-Art Review and Perspective

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Journal of Remote Sensing 2021年第1期2021卷 211-236页

作者： Ruiliang Pu School of Geosciences University of South Florida4202 E.Fowler Ave.NES 107TampaFL 33620USA

Timely and accurate information on tree species(TS)is crucial for developing strategies for sustainable management and conservation of artificial and natural *** the last four decades,advances in remote sensing technologies have made TS classification *** many studies on the topic have been conducted and their comprehensive results and novel findings have been published in the literature,it is necessary to conduct an updated review on the status,trends,potentials,and challenges and to recommend future *** review will provide an overview on various optical and light detection and ranging(LiDAR)sensors;present and assess current various techniques/methods for,and a general trend of method development in,TS classification;and identify limitations and recommend future *** this review,several concluding remarks were *** include the following:(1)A large group of studies on the topic were using high-resolution satellite,airborne multi-/hyperspectral imagery,and airborne LiDAR data.(2)A trend of“multiple”method development for the topic was observed.(3)Machine learning methods including deep learning models were demonstrated to be significant in improving TS classification accuracy.(4)Recently,unmanned aerial vehicle-(UAV-)based sensors have caught the interest of researchers and practitioners for the topic-related research and *** addition,three future directions were recommended,including refining the three categories of“multiple”methods,developing novel data fusion algorithms or processing chains,and exploring new spectral unmixing algorithms to automatically extract and map TS spectral information from satellite hyperspectral data.

关键词： directions LiDAR Remote

A Review of Empirical Research on Transformational School Leadership in China(2010-2019)

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ECNU Review of Education 2022年第1期5卷 156-184页

作者： Yanzheng Li University of South Florida 4202 E.Fowler AvenueTampaFL 33620USA

Purpose:The purpose of this literature review is to investigate the effectiveness of transformational school leadership(TSL)in Chinese K-12 settings between 2010 and *** main objective is to provide a comprehensive understanding of TSL research in China and identify the possible future research ***/Approach/Methods:Vote counting method and narrative synthesis were applied in this ***:This review found the majority of the studies were quantitative,which indicates that qualitative and mixed-method studies should be *** review also identified 12 major outcome variables,including 9 teacher-level variables,2 school-level variables,and 1 student-level ***,the effects of transformational leadership on these outcome variables were uniformly significant,including both direct and indirect *** studies should expand the scope of school-level and student-level outcome variables,but particularly student-level outcome ***/Value:This is the first systematic review on the effectiveness of TSL research in China,which included both English and Chinese studies.

关键词： China literature review transformational school leadership

The Treatment of Partial-Thickness Burns with a Hydroconductive Wound Dressing: Clinical and Mechanistic Effects

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Surgical Science 2013年第5期4卷 268-272页

作者： David J. Smith Rachel A. Karlnoski Ami Patel C. Wayne Cruse Kimberly S. Brown Martin C. Robson Department of Surgery University of South Florida Tampa USA Florida Gulf-to-Bay Anesthesiology Associates LLC Tampa USA tampa General Hospital Burn Center Tampa USA

Objectives: Edema in partial-thickness burn wounds can decrease tissue perfusion, increase tissue ischemia, and deepen the burn injury. We report the results of a clinical trial comparing the effectiveness of a hydro-conductive dressing to our standard burn dressing at removing edema fluid from partial-thickness burns and present the proposed mechanisms of action of the hydroconductive dressing. Methods: An internally controlled comparison of two wound dressings was performed on 10 patients with non-contiguous partial-thickness burns. Each patient served as his/her own control. One burn was treated with our standard burn dressing and the other with hydroconductive dressing. Dressings were weighed prior to application, removed at 24 and 48 hours, weighed, and new pre-weighed dressings applied. Weight gain of each dressing at 24 and 48 hours was determined. Statistics were applied using the Student’s paired T-test. The VAS pain scale was measured prior to, during, and after each dressing change. Results: At 24 hours, the hydroconductive dressing had increased 85.6% ± 29.3% in weight compared with 61.3% ± 32.7% for the control (P = 0.053). For the second 24 hour period, the respective numbers were statistically significantly different at 59.7% ± 23.4% vs. 34.2% ± 19.1% (P = 0.038). Averaging the weight gain over the two dressing periods demonstrated that the differences were highly statistically significant as the hydroconductive dressing increased in weight by 71.0% ± 20.3% compared with 44.5% ± 17.4% for the gauze dressing (P = 0.005). VAS scores revealed no statistical differences. Mechanisms of action included capillary, hydroconductive, and electrostatic actions. Conclusions: A hydroconductive dressing designed to draw off excessive wound fluid removes more wound edema fluid than standard burn gauze dressings.

关键词： Burn Wound Edema

A review and future prospects of renewable energy in the global energy system

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电工电能新技术 2008年第1期27卷 55-62页

作者： D Yogi GOSWAMI John ＆ Naida Ramil Professor Co-Director Clean Energy Research Center University of South Florida Tampa Florida 33620 USA

Global energy consumption in the last half century has rapidly increased and is expected to continue to grow over the next 50 years,however,with significant *** past increase was stimulated by relatively "cheap" fossil fuels and increased rates of industrialization in North America,Europe and Japan;yet while energy consumption in these countries continues to increase,additional factors make the picture for the next 50 years more *** additional complicating factors include China and India's rapid increase in energy use as they represent about a third of the world's population;the expected depletion of oil resources in the near future;and,the effect of human activities on global climate *** the positive side,the renewable energy(RE) technologies of wind,bio-fuels,solar thermal and photovoltaics(PV) are finally showing maturity and the ultimate promise of cost competitiveness.

关键词：可再生能源全球能源系统发展前景能源消费能源需求节能

Three-dimensional mapping and comparative analysis of the distal human corpus cavernosum and the inflatable penile prosthesis

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Asian Journal of Andrology 2013年第4期15卷 567-570,I0012页

作者： Tariq S Hakky Daniel Ferguson Philippe E Spiess Paul Bradley Tom FLue Rafael E Carrion Department of Urology University of South Florida tampa General Circle Tampa FL 33602 USA 23D3Solutions Burnaby BCV5J 5M8 Canada and Department of Urology University of Southern California San Francisco 400 Parnassus Ave San Francisco CA 94143 USA

The intricate anatomy of the corpus cavernosum in both the flaccid and tumescent state has not been fully elucidated. We report our experience using a three-dimensional （3D） scanner to reconstruct cadaveric casts and compare them with 3D images of two prototypes of penile prosthesis. Two different models of the Titan Coloplast inflatable penile prosthesis were analyzed using a 3D scanner. The first was the standard model and the second was a newer model with a rounder silicone tip. Two cadaveric phalluses were harvested using Smooth-Cast 300Q polyurethane molding. The molds were excised and scanned along side the penile prosthesis. 3D scans were completed and analyzed using Leios Mesh software, and GOM Inspect software. The 3D scans demonstrated the mean human corporal radii 2 mm from the distal tip to be 36.51 mm （36.01-37.0 mm）, which is an obtuse angle. The standard Titan penile prosthesis spherical radius at the same level was 202.52 mm, while the new silicone tip prosthesis had a radius of 139.33 mm. 3D mapping further demonstrated the trajectory of the cavernosa appeared curvilinear and the distal ends appeared blunt. The use of cadaveric cavernosal molds in combination with the 3D scanner allowed us to accurately image the corpus cavernosum for the first time. Our findings suggest that anatomically accurate corporal tips appear to be relatively blunt and that the new Titan silicone tip penile prosthesis more closely resembles the human corporal tip.

关键词： corpus cavernosum penile prosthesis three-dimensional analysis

Stem cell-derived extracellular vesicles as potential mechanism for repair of microvascular damage within and outside of the central nervous system in amyotrophic lateral sclerosis:perspective schema

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Neural Regeneration Research 2021年第4期16卷 680-681页

作者： Svitlana Garbuzova-Davis Cesario V.Borlongan Center of Excellence for Aging&Brain Repair Department of Neurosurgery and Brain RepairUniversity of South FloridaMorsani College of MedicineTampaFLUSA Department of Molecular Pharmacology and Physiology Department of Pathology and Cell BiologyUniversity of South FloridaMorsani College of MedicineTampaFLUSA

Microvascular alterations within and outside the central nervous system(CNS)in amyotrophic lateral sclerosis(ALS):ALS is a fatal neurodegenerative disease leading to paralysis and eventual death within 3 to 5 years of diagnosis due to respiratory *** pathogenic intrinsic and extrinsic effectors are involved in the diffuse motor neuron ***,impairment of neurovascular unit components in the brain and spinal cord in ALS patients and in animal models of disease was noted and points to vascular pathology being a key factor in the recognition of ALS as a neurovascular disease(Garbuzova-Davis et al.,2011).

关键词： damage alterations diagnosis

Hypo-endemic onchocerciasis hotspots: defining areas of high risk through micro-mapping and environmental delineation

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Infectious Diseases of Poverty 2015年第1期4卷 283-289页

作者： Louise A.Kelly-Hope Thomas R.Unnasch Michelle C.Stanton David H.Molyneux Liverpool School of Tropical Medicine Pembroke PlaceLiverpool L35QAUK University of South Florida TampaFloridaUSA

Background:Onchocerciasis(river blindness)caused by the parasite Onchocercavolvulus and transmitted by riverine Simulium spp.(Black flies)is targeted for elimination in *** is a significant change in strategy from the‘control’of meso-and hyper-endemic areas through mass drug administration(MDA)with Mectizan®(ivermectin),to the‘elimination’in all endemic areas where a range of interventions may be *** most significant challenges of elimination in low transmission or hypo-endemic areas are ***,there are vast remote areas where the focality of low transmission is relatively ***,the treatment with ivermectin increases the risk of serious adverse events(SAEs)in individuals with high parasitaemias of Loa loa,a filarial parasite widespread in Central and West Africa,which causes Tropical eye worm and transmitted by Chrysops spp.(Deer flies).Discussion:We therefore propose novel mapping approaches using remote sensing satellite and modelled environmental data to be used in combination with rapid field surveys to help resolve the problems of targeting the expansion of onchocerciasis elimination activities in *** co-endemic ***,we demonstrate that micro-stratification overlap mapping(MOM)of available onchocerciasis and loiasis prevalence maps can be used to identify 12 key high risk areas,where low *** high *** transmission overlap,which we define as“hypo-endemic hotspots”.Second we show that integrated micro-mapping of prevalence data,and the use of environmental data to delineate riverine and forest risk factors associated with Simulium *** Chrysops *** habitats can further help to define target intervention areas *** hotspots within hotspots,to help avoid the risk of ***:These mapping examples demonstrate the value of bringing prevalence,entomological and ecological information together to develop maps for planned implementation and targeted *** is critical as better ma

关键词： Onchocerciasis River blindness Loa loa Loiasis Severe adverse events Mapping Elimination Environment Africa

Minimally invasive image-guided therapy of primary and metastatic pancreatic cancer

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World Journal of Gastroenterology 2021年第27期27卷 4322-4341页

作者： Andras Bibok Dae Won Kim Mokenge Malafa Bela Kis Department of Diagnostic Imaging and Interventional Radiology H.Lee Moffitt Cancer CenterTampaFL 33612United States Department of Transplantation&Surgery Radiology UnitSemmelweis UniversityBudapest 1085Hungary Department of Gastrointestinal Oncology H.Lee Moffitt Cancer CenterTampaFL 33612United States

Pancreatic cancer is a challenging malignancy with limited treatment options and poor life *** only curative option is surgical resection,but only 15%-20%of patients are resectable at presentation because more than 50%of patients has distant metastasis at diagnosis and the rest of them has locally advanced pancreatic cancer(LAPC).The standard of care first line treatment for LAPC patients is chemotherapy with or without radiation *** developments in minimally invasive ablative techniques may add to the treatment armamentarium of *** are increasing number of studies evaluating these novel ablative techniques,including radiofrequency ablation,microwave ablation,cryoablation and irreversible *** studies which included pancreatic tumor ablation,demonstrated improved overall survival in LAPC ***,the exact protocols are yet to set up to which stage of the treatment algorithm ablative techniques can be added and in what kind of treatment *** with metastatic pancreatic cancer has dismal prognosis with 5-year survival is only 3%.The most common metastatic site is the liver as 90%of pancreatic cancer patients develop liver *** is the primary treatment option for patients with metastatic pancreatic ***,when the tumor is not responding to chemotherapy or severe drug toxicity develops,locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease progression and improve survival in selected *** the last decade new therapeutic options arose with the advancement of minimally invasive technologies to treat pancreatic cancer *** new therapies have been a topic of increasing interest due to the severe prognostic implications of locally advanced and metastatic pancreatic cancer and the low comorbid risk of these *** review summarizes new ablative options for patients with LAPC and percutaneous liver-directed th

关键词： Pancreatic neoplasms Interventional radiology Ablation techniques Electroporation Radiofrequency ablation Therapeutic embolization

GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis

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Translational Neurodegeneration 2018年第1期7卷 322-345页

作者： William R.Swindell Krzysztof Bojanowski Mark S.Kindy Raymond M.W.Chau Dorothy Ko Heritage College of Osteopathic Medicine Ohio UniversityAthensOHUSA Sunny BioDiscovery IncSanta PaulaCAUSA Department of Pharmaceutical Sciences College of PharmacyUniversity of South FloridaTampaFLUSA James A.Haley VAMC TampaFLUSA Genervon Biopharmaceuticals LLC PasadenaCAUSA

Background:Amyotrophic lateral sclerosis(ALS)is currently an incurable disease without highly effective pharmacological *** peptide drug GM604(GM6 or Alirinetide)was developed as a candidate ALS therapy,which has demonstrated safety and good drug-like properties with a favorable pharmacokinetic ***6 is hypothesized to bolster neuron survival through the multi-target regulation of developmental pathways,but mechanisms of action are not fully ***:This study used RNA-seq to evaluate transcriptome responses in SH-SY5Y neuroblastoma cells following GM6 treatment(6,24 and 48 h).Results:We identified 2867 protein-coding genes with expression significantly altered by GM6(FDR<0.10).Early(6 h)responses included up-regulation of Notch and hedgehog signaling components,with increased expression of developmental genes mediating neurogenesis and axon *** GM6 treatment(24 and 48 h)altered the expression of genes contributing to cell adhesion and the extracellular ***6 further down-regulated the expression of genes associated with mitochondria,inflammatory responses,mRNA processing and chromatin ***6-increased genes were located near GC-rich motifs interacting with C2H2 zinc finger transcription factors,whereas GM6-decreased genes were located near AT-rich motifs associated with helix-turn-helix homeodomain *** motifs interacted with a diverse network of transcription factors encoded by GM6-regulated genes(STAT3,HOXD11,HES7,GLI1).We identified 77 ALS-associated genes with expression significantly altered by GM6 treatment(FDR<0.10),which were known to function in neurogenesis,axon guidance and the intrinsic apoptosis ***:Our findings support the hypothesis that GM6 acts through developmental-stage pathways to influence neuron *** expression responses were consistent with neurotrophic effects,ECM modulation,and activation of the Notch and hedgehog neurodevelopmental *** multif

关键词： Alzheimer’s disease Amyotrophic lateral sclerosis Extracellular matrix,Hedgehog Huntington’s disease Neurodegenerative disease Notch,Parkinson’s disease RNA-seq Transcriptome