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Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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Nano Research 2024年第8期17卷 7436-7448页

作者： Ze Qiang Zhao Bo Zhi Chen Jia Li Gan Yun Hao Feng Ling Liang Lingyun Yu Zi Yi Wang Samin Abbaszadeh Mohammad-Ali Shahbazi Ruixing Yu Xin Dong Guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-Japan Friendship hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

Risk Factors and Syndromic Management of Sexually Transmitted Infections among Sex Workers in the Kadiolo Circle

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Advances in Infectious Diseases 2021年第2期11卷 95-103页

作者： Diarra Aminta Cissoko Yacouba Konate Issa Matchim Kouam Clemence Samake Dramane Traore Madou Daou Sounkalo support and counseling care unit for people living with hiv/aids dermatology hospital Bamako Mali Infectious and Tropical Diseases Department of the University hospital of Point G Bamako Mali Mopti Regional hospital Mopti Mali Sikasso Regional hospital Sikasso Mali

Sexually transmitted infections constitute a gateway for the human immunodeficiency virus by the presence of ulcerations and local inflammatory manifestations, thus increasing the risk of transmission. The aim of the study was to assess the sexual behavior and syndromic management of sexual infections among female sex workers in the Kadiolo circle. Material and method: This was a descriptive cross-sectional study carried out in the Kadiolo circle from January 1 to December 31, 2014. It focused on clandestine or posted sex workers, aged 15 and over. Results: We collected 465 sex workers aged 15 and 49, aged 26.6 on average and from Ivory Coast 52%, Nigeria 26.2% and Mali 9.7%. Educational attainment was higher with 2.4%. Posted sex workers represented 92.5% and housed in brothels with a stay of 6 months with 53.3%. They were single with 70.8% of cases and about 72.9% lived alone and without a spouse. The age at first sexual intercourse was between 15 - 19 years with 76.6% of cases. The number of first commercial sex was between 15 - 19 years (26%) and 20 - 24 years (45.8%). Usual condom use with regular sex partners was 22.1%. Condom use was almost compulsory at 89.7% with occasional clients or non-regular sexual partners. The average number of clients per day was five (5). The major reason for consultation was vaginal discharge 16.4% followed by abdominal pain. The human immunodeficiency virus test was not compulsory and only 86 workers or 18.5% accepted with a positive result of 11 people or 12.8% of cases. Conclusion: Sexually transmitted infections are common especially as they affect young people.

关键词： Sex Worker Kadiolo Infectious Disease

Reductive damage induced autophagy inhibition for tumor therapy

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Nano Research 2023年第4期16卷 5226-5236页

作者： Yuqian Wang Yingjian Huang Yu Fu Zhixiong Guo Da Chen Fangxian Cao Qi Ye Qiqi Duan Meng Liu Ning Wang Dan Han Chaoyi Qu Zhimin Tian Yongquan Qu Yan Zheng Department of dermatology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of dermatology the Second Affiliated HospitalSchool of MedicineXi’an Jiaotong UniversityXi’an 710004China School of Chemical Engineering and Technology Shaanxi Key Laboratory of Energy Chemical Process IntensificationXi’an Jiaotong UniversityXi’an 710049China Department of Urology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Xi’an people’s hospital(Xi’an Fourth hospital) Shaanxi Eye HospitalAffiliated Guangren HospitalSchool of MedicineXi’an Jiaotong UniversityXi’an 710004China

Numerous therapeutic anti-tumor strategies have been developed in recent ***,their therapeutic efficacy is reduced by the intrinsic protective autophagy of *** plays a key role in tumorigenesis and tumor treatment,in which the overproduction of reactive oxygen species(ROS)is recognized as the direct cause of protective *** a few molecules have been employed as autophagy inhibitors in tumor therapy to reduce protective *** them,hydroxychloroquine is the most commonly used autophagy inhibitor in clinics,but it is severely limited by its high therapeutic dose,significant toxicity,poor reversal efficacy,and nonspecific ***,we demonstrate a reductive-damage strategy to enable tumor therapy by the inhibition of protective autophagy via the catalytic scavenging of ROS using porous nanorods of ceria(PN-CeO_(2))nanozymes as autophagy *** antineoplastic effects of PN-CeO_(2)were mediated by its high reductive activity for intratumoral ROS degradation,thereby inhibiting protective autophagy and activating apoptosis by suppressing the activities of phosphatidylinositide 3-kinase/protein kinase B and p38 mitogen-activated protein kinase pathways in human cutaneous squamous cell *** investigation highlighted PN-CeO_(2)as a safe and efficient anti-tumor autophagy ***,this study presents a reductive-damage strategy as a promising anti-tumor approach that catalytically inhibits autophagy and activates the intrinsic antioxidant pathways of tumor cells and also shows its potential for the therapy of other autophagy-related diseases.

关键词： CeO_(2) reductive damage autophagy inhibitor tumor therapy reactive oxygen species

A hydrogel system containing molybdenum-based nanomaterials for wound healing

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Nano Research 2023年第4期16卷 5368-5375页

作者： Yongzhou Lu Chuanlong Jia Chengchen Gong Han Wang Qin Xiao Jinxiao Guo Dalong Ni Nan Xu Department of dermatology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Orthopaedics Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China

Wound delayed healing or non-healing has seriously affected patients’quality of life and has been a significant economic burden for public health systems *** reactive oxygen species(ROS)play important roles for impeding the process of wound ***,we report a hydrogel system containing low-valence-state molybdenum nanomaterials(Mo hydrogel)for wound healing by scavenging the detrimental *** in vitro and in vivo results demonstrate that the synthesized Mo hydrogel can accelerate wound healing,promote angiogenesis,and stimulate the expression of growth *** the molybdenum is an essential element for the survival of all organisms,such novel Mo-hydrogel has the great potential to be clinically translated for wound healing.

关键词： antioxidants wound healing hydrogel reactive oxygen species molybdenum

An outbreak of Mycobacterium marinum infection associated with handling seabass in China

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Chinese Medical Journal 2022年第21期135卷 2617-2619页

作者： Qing Zhao Fangfang Bao Zihao Mi Zhenzhen Wang Pengcheng Huai Qing Pan Zheng Pang Yaoming Li Nan Cao Xiaotong Xue Buyan Li Xuechao Chen Jinliang Wang Yanxia Cui Wenqian Chang Yuan Zhang Zhenhua Yue Yongxia Liu Zhenhua Wang Weiguo Yan Jinyong Li Hongqing Tian Xianmei Lu Guizhi Zhou Jianjun Liu Hong Liu Furen Zhang Shandong Provincial hospital for Skin Diseases&Shandong Provincial Institute of dermatology and Venereology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Shangkou hospital ShouguangShandong 262732China Shouguang people’s hospital ShouguangShandong 261000China Weifang people’s hospital WeifangShandong 261000China Shouguang hospital for Skin Diseases ShouguangShandong 261000China Weifang hospital for Skin Diseases WeifangShandong 261000China Human Genetics Genome Institute of SingaporeA∗STARRepublic of Singapore

To the Editor:Mycobacterium marinum is a nontuberculous mycobacterium that can cause opportunistic infections in humans,ranging from a single cutaneous lesion to disseminated disease.[1]It was first isolated from a fish in 1926 and identified as a cause of human infection in 1951.[1]The estimated annual incidence ranges from 0.04 to 0.27 per 100,000 persons in different *** of *** infections related to handling fish are not common,but have also been reported.

关键词： infection ed. infections

Efficient gene transfection of suspension cells by highly branched poly(β-amino ester)

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Chinese Chemical Letters 2023年第7期34卷 176-181页

作者： Delu Che Chenfei Wang Zhili Li Kaixuan Wang Shuaiwei Sun Xinyue Zhang Yi Li Zhengju Chen Lei Guo Yajing Hou Dezhong Zhou Songmei Geng Department of dermatology the Second Hospital Affiliated to Xi'an Jiaotong UniversityXi'an 710061China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an 710049China Infectious Disease Department the Second Xiangya Hospital of Central South UniversityChangsha 410011China Pooling Medical Research Institutes Hangzhou 310053China Department of Pharmacy Shaanxi Provincial People's HospitalXi'an 710068China

Suspension cells play a crucial role in many biological processes. However, compared to adherent cells, it is particularly challenging to introduce exogenous genes into suspension cells to regulate their biological functions with non-viral gene vectors, mainly due to the low cellular uptake and endosomal escape of polyplexes. Herein, to improve the interactions of polyplexes with cellular membranes, we design and synthesize highly branched poly(β-amino ester)(HPAE) via an “A2 + B4 + C2” Michael addition *** show that branching significantly increases DNA condensation of HPAE, cellular uptake and endosomal escape of HPAE/DNA polyplexes. In mast cells(MCs), HPAE exhibits up to 80-fold higher gene transfection efficiency compared to the corresponding linear poly(β-amino ester)(LPAE) and the leading commercial gene transfection reagents PEI25k, jetPEI, and Lipofectamine 3000, without causing obvious cytotoxicity. Our study establishes a reliable non-viral platform for efficient gene transfection of suspension cells.

关键词： Non-viral vector Highly branched poly(β-amino ester) Gene transfection High transfection efficiency Suspension cells Mast cells

Multiplexed Profiling of Extracellular Vesicles for Biomarker Development

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Nano-Micro Letters 2022年第1期14卷 59-94页

作者： Cheng Jiang Ying Fu Guozhen Liu Bowen Shu Jason Davis George K.Tofaris Nuffield Department of Clinical Neurosciences New Biochemistry BuildingUniversity of OxfordOxford OX13QUUK Department of Chemistry University of OxfordOxford OX13QZUK School of Life and Health Sciences The Chinese University of Hong KongShenzhen 518172People’s Republic of China dermatology hospital Southern Medical UniversityGuangzhou 510091People’s Republic of China Kavli Institute for Nanoscience Discovery New Biochemistry BuildingUniversity of OxfordOxfordUK

Extracellular vesicles(EVs)are cell-derived membranous particles that play a crucial role in molecular trafficking,intercellular transport and the egress of unwanted *** have been implicated in many diseases including cancer and *** are detected in all bodily fluids,and their protein and nucleic acid content offers a means of assessing the status of the cells from which they *** such,they provide opportunities in biomarker discovery for diagnosis,prognosis or the stratification of diseases as well as an objective monitoring of *** simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application,and multiplexing platforms have evolved with the potential to achieve ***,we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis,with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power,throughput and consistency.

关键词： Multiplexed profiling Extracellular vesicles Exosomes Liquid biopsy Point-of-care Biomarker

Post-traumatic stress disorder status in a rescue group after the Wenchuan earthquake relief

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Neural Regeneration Research 2013年第20期8卷 1898-1906页

作者： Junhua Huang Qunying Liu Jinliang Li Xuejiang Li Jin You Liang Zhang Changfu Tian Rongsheng Luan Department of Epidemiology Huaxi Public Health School of Sichuan University Yunnan General hospital of the Chinese people's Armed Police Forces Department of Psychological counseling Yunnan General Hospital of the Chinese People's Armed Police Forces Department of Psychological counseling Sichuan General Hospital of the Chinese People's Armed Police Forces Department of Infectious Diseases First Affiliated Hospital of Kunming Medical College Kunming Center for Disease Control Scientific Research and Experimental Center Kunming Medical College

Previous studies have suggested that the incidence of post-traumatic stress disorder in earthquake rescue workers is relatively high. Risk factors for this disorder include demographic characteristics, earthquake-related high-risk factors, risk factors in the rescue process, personality, social support and coping style. This study examined the current status of a unit of 1 040 rescue workers who participated in earthquake relief for the Wenchuan earthquake that occurred on May 12th, 2008. Post-traumatic stress disorder was diagnosed primarily using the Clinician-Administered Post-traumatic Stress Disorder Scale during structured interviews. Univariate and multivariate sta-tistical analyses were used to examine major risk factors that contributed to the incidence of post-traumatic stress disorder. Results revealed that the incidence of this disorder in the rescue group was 5.96%. The impact factors in univariate analysis included death of family members, contact with corpses or witnessing of the deceased or seriously injured, near-death experience, severe injury or mental trauma in the rescue process and working at the epicenter of the earthquake. Correlation analysis suggested that post-traumatic stress disorder was positively correlated with psychotic and neurotic personalities, negative coping and low social support. Impact factors in mul-tivariate logistic regression analysis included near-death experience, severe injury or mental trauma, working in the epicenter of the rescue, neurotic personality, negative coping and low social support, among which low social support had the largest odds ratio of 20.42. Findings showed that the oc-currence of post-traumatic stress disorder was the result of the interaction of multiple factors.

关键词： neural regeneration post-traumatic stress disorder incidence Wenchuan earthquake rescue groups influencing factor coping style personality social support cross-sectional investigation risk factors neuroregeneration

Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders

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Cellular & Molecular Immunology 2020年第1期17卷 64-75页

作者： Ling Chen Zhu Shen Department of dermatology Daping HospitalArmy Medical UniversityChongqing 400042China Department of dermatology Institute of Dermatology and VenereologySichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China

The skin is the largest organ of the *** establishment of immunological memory in the skin is a crucial component of the adaptive immune *** naive T cells are activated by antigen-presenting cells,a small fraction of them differentiate into precursor memory T *** precursor cells ultimately develop into several subsets of memory T cells,including central memory T(TCM)cells,effector memory T(TEM)cells,and tissue resident memory T(TRM)*** cells have a unique transcriptional profile,and their most striking characteristics are their long-term survival(longevity)and low migration in peripheral tissues,including the *** physiological conditions,TRM cells that reside in the skin can respond rapidly to pathogenic ***,there is emerging evidence to support the vital role of TRM cells in the recurrence of chronic inflammatory skin disorders,including psoriasis,vitiligo,and fixed drug eruption,under pathological or uncontrolled *** and characterizing the mechanisms that are involved in skin TRM cells will help provide promising strategies for reducing the frequency and magnitude of skin inflammation ***,we discuss recent insights into the generation,homing,retention,and survival of TRM cells and share our perspectives on the biological characteristics of TRM cells in the recurrence of inflammatory skin disorders.

关键词： Tissue-resident Memory T cells Skin inflammatory disorders Recurrence Psoriasis