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Estrogen restores disordered lipid metabolism in visceral fat of prediabetic mice

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World Journal of diabetes 2024年第5期15卷 988-1000页

作者： Su-Huan Liu Zhao-Shui Shangguan Paiziliya Maitiaximu Zhi-Peng Li Xin-Xin Chen Can-dong Li research base of Chinese Medicine Syndrome Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina research Center for translational Medicine The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361003Fujian ProvinceChina

BACKGrOUNd Visceral obesity is increasingly prevalent among adolescents and young adults and is commonly recognized as a risk factor for type 2 ***[17β-estradiol(E2)]is known to offer protection against obesity via diverse me-chanisms,while its specific effects on visceral adipose tissue(VAT)remain to be fully *** To investigate the impact of E2 on the gene expression profile within VAT of a mouse model of *** Metabolic parameters were collected,encompassing body weight,weights of visceral and subcutaneous adipose tissues(VAT and SAT),random blood glucose levels,glucose tolerance,insulin tolerance,and overall body *** gene expression profiles of VAT were quantified utilizing the Whole Mouse Genome Oligo Microarray and subsequently analyzed through Agilent Feature Extraction *** and pathway analyses were conducted employing Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses,*** Feeding a high-fat diet(HFd)moderately increased the weights of both VAT and SAT,but this increase was mitigated by the protective effect of endogenous ***,ovariectomy(OVX)led to a significant increase in VAT weight and the VAT/SAT weight ratio,and this increase was also reversed with E2 ***,OVX diminished the expression of genes involved in lipid metabolism compared to HFd feeding alone,signaling a widespread reduction in lipid metabolic activity,which was completely counteracted by E2 *** study provides a comprehensive insight into E2's local and direct protective effects against visceral adiposity in VAT at the gene *** In conclusion,the present study demonstrated that the HFd-induced over-nutritional challenge disrupted the gene expression profile of visceral fat,leading to a universally decreased lipid metabolic status in E2 deficient mice.E2 treatment effectively reversed this condition,shedding light on the mechanistic role and thera

关键词： Estrogen Obesity,Visceral adiposity Energy metabolism Type 2 diabetes

Accelerating the Screening of Modified MA2Z4 Catalysts for Hydrogen Evolution reaction by deep Learning-based Local Geometric Analysis

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ENErGY & ENVIrONMENTAL MATErIALS 2024年第6期7卷 290-302页

作者： Zheng, Jingnan Wang, Shibin deng, Shengwei Yao, Zihao Hu, Junhua Wang, Jianguo Zhejiang Univ Technol Inst Ind Catalysis Coll Chem Engn State Key Lab Breeding Base Green Chem Synth Techn Hangzhou 310032 Peoples R China Zhengzhou Univ Sch Mat Sci & Engn Zhengzhou 450001 Peoples R China Zhengzhou Univ State Ctr Int Cooperat Designer Low Carbon & Envir Sch Mat Sci & Engn Zhengzhou 450001 Peoples R China

Machine learning (ML) integrated with density functional theory (dFT) calculations have recently been used to accelerate the design and discovery of single-atom catalysts (SACs) by establishing deep structure-activity relationships. The traditional ML models are always difficult to identify the structural differences among the single-atom systems with different modification methods, leading to the limitation of the potential application range. Aiming to the structural properties of several typical two-dimensional MA(2)Z(4)-based single-atom systems (bare MA(2)Z(4) and metal single-atom doped/supported MA(2)Z(4)), an improved crystal graph convolutional neural network (CGCNN) classification model was employed, instead of the traditional machine learning regression model, to address the challenge of incompatibility in the studied systems. The CGCNN model was optimized using crystal graph representation in which the geometric configuration was divided into active layer, surface layer, and bulk layer (ASB-GCNN). Through ML and dFT calculations, five potential single-atom hydrogen evolution reaction (HEr) catalysts were screened from chemical space of 600 MA(2)Z(4)-based materials, especially V-1/HfSn2N4(S) with high stability and activity (delta G(H*) is 0.06 eV). Further projected density of states (pdOS) analysis in combination with the wave function analysis of the SAC-H bond revealed that the SAC-dz(2) orbital coincided with the H-s orbital around the energy level of -2.50 eV, and orbital analysis confirmed the formation of sigma bonds. This study provides an efficient multistep screening design framework of metal single-atom catalyst for HEr systems with similar two-dimensional supports but different geometric configurations.

关键词： graph convolutional neural network hydrogen evolution reaction modified MA(2)Z(4) substrate single atom catalyst MONOLAYEr MACHINE

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MrN-ATM axis in the dNA damage response

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Genes & diseases 2024年第1期11卷 19-22页

作者： Zhenhai Li Wenchao Xu Feng Chen Jun Zhang Wei-Guo Zhu Guangdong Key Laboratory of Genome Instability and Human disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhenGuangdong 518055China base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines r&d Center International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay Laboratory Shenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical Engineering Shenzhen University School of MedicineShenzhenGuangdong 518055China

Etoposide is widely used for cancer chemotherapy in the ***,long-term etoposide treatment can lead to adverse effects or drug *** improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer ***,we showed Brd4,one of the main targets of BET inhibitors,was involved in dNA damage response(ddr)via the homologous recombination(Hr)repair pathway.

关键词： etoposide damage cancer

Harnessing cytokine-induced killer cells to accelerate diabetic wound healing:an approach to regulating post-traumatic inflammation

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regenerative Biomaterials 2024年第2期3卷 88-99页

作者： Yixi Yang Cheng Zhang Yuan Jiang Yijun He iawei Cai Lin Liang Zhaohuan Chen Sicheng Pan Chu Hua Keke Wu Le Wang Zhiyong Zhang translational research Centre of regenerative Medicine and 3d Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China department of Osteoarthropathy and Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface *** clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive ***,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical *** the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to *** demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory *** *** accelerateskin healing in diabetic *** results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic *** novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关键词： macrophage diabetic wound post-traumatic inflammation cytokine-induced killer cells vascularization

Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

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Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： Yan-Qiang Huang Yuan-Feng Li Yong Liu Lin-Qi Shi Guangxi Technology Innovation Cooperation base of Prevention and Control Pathogenic Microbes with drug resistance Youjiang Medical University for NationalitiesBaise533000China translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug ring-opening polymerization Biofilm eradication Cytotoxicity

recent Advances in deciphering the Mechanisms and Biological Functions of dNA demethylation

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Chinese Journal of Chemistry 2024年第6期42卷 645-651页

作者： Yang Feng Sheng-Jun Chen Bi-Feng Yuan Key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational R&D Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong510300 China School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhanHubei430071 China

5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic dNA of higher *** has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TET)-mediated oxidation of 5mC followed by thymine dNA glycosylase (TdG)-initiated base excision repair (BEr).recent findings also have identified an alternative pathway of dNA *** this pathway,TET enzymes directly oxidize 5mC to form 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC).These modified bases can undergo direct deformylation or decarboxylation,***,dNA demethylation can also occur through the deamination of 5mC and 5hmC,resulting in the production of thymine and 5-hydroxymethyluracil (5hmU),*** dNA demethylation pathways possess critical functional implications and roles in biological *** recent Advances article will focus on the studies of mechanisms and biological functions of dNA demethylation,shedding light on the reversible nature of the epigenetic modification of 5mC.

关键词： Epigenetics dNA dNA methylation 5-Methylcytosine demethylation Mechanisms Biological functions C—C bond cleavage Mass spectrometry

Novel insights on oral squamous cell carcinoma management using long non-coding rNAs

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Oncology research 2024年第10期32卷 1589-1612页

作者： SUBHAYAN SUr dIMPLE dAVrAY SOUMYA BASU SUPrIYA KHEUr JAYANTA KUMAr PAL SHUCHI NAGAr AVINASH SANAP BHIMAPPA MrUdAGI SAMIr GUPTA Cancer and translational research Centre Dr.D.Y.Patil Biotechnology and Bioinformatics InstituteDr.D.Y.Patil VidyapeethTathawadePune411033India Bioinformatics Centre Dr.D.Y.Patil Biotechnology and Bioinformatics InstituteDr.D.Y.Patil VidyapeethPune411033India department of Oral Pathology and Microbiology Dr.D.Y.Patil Dental College&HospitalDr.D.Y.Patil VidyapeethPune411018India department of Surgical Oncology Dr.D.Y.Patil Medical CollegeHospital&Research CentreDr.D.Y.Patil VidyapeethPune411018India

Oral squamous cell carcinoma(OSCC)is one of the most prevalent forms of head and neck squamous cell carcinomas(HNSCC)with a poor overall survival rate(about 50%),particularly in cases of ***-based cancer biomarkers are a relatively advanced concept,and non-coding rNAs currently have shown promising roles in the detection and treatment of various *** review underlines the function of long non-coding rNAs(lncrNAs)in the OSCC and its subsequent clinical ***,a class of non-coding rNAs,are larger than 200 nucleotides and resemble mrNA in numerous ***,unlike mrNA,lncrNA regulates multiple druggable and non-druggable signaling molecules through simultaneous interaction with dNA,rNA,proteins,or microrNAs depending on concentration and localization in *** of oncogenic lncrNAs and downregulation of tumor suppressor lncrNAs are evident in OSCC tissues and body fluids such as blood and saliva indicating their potential as valuable *** inhibition of candidate oncogenic lncrNAs or overexpression of tumor suppressor lncrNAs showed potential therapeutic roles in in-vivo animal *** types of lncrNAs that are expressed differentially in OSCC tissue and bodily fluids have been systematically documented with specificity and *** review thoroughly discusses the biological functions of such lncrNAs in OSCC cell survival,proliferation,invasion,migration,metastasis,angiogenesis,metabolism,epigenetic modification,tumor immune microenvironment,and drug ***,we addressed the diagnostic and therapeutic importance of lncrNAs in OSCC pre-clinical and clinical systems,providing details on ongoing research and outlining potential future directions for advancements in this *** essence,this review could be a valuable resource by offering comprehensive and current insights into lncrNAs in OSCC for researchers in fundamental and clinical domains.

关键词： Oral squamous cell carcinoma(OSCC) Head and neck cancer Non-coding rNA Long non-coding rNA(lncrNA) Cancer diagnosis

Value of multiple models of diffusion-weighted imaging to predict hepatic lymph node metastases in colorectal liver metastases patients

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World Journal of Gastroenterology 2024年第4期30卷 308-317页

作者： Hai-Bin Zhu Bo Zhao Xiao-Ting Li Xiao-Yan Zhang Qian Yao Ying-Shi Sun Key Laboratory of Carcinogenesis and translational research(Ministry of Education/Beijing) Department of RadiologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and translational research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGrOUNd About 10%-31% of colorectal liver metastases(CrLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindication for liver *** to now,there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CrLM,except for pathology examination of lymph node after *** To compare the ability of mono-exponential,bi-exponential,and stretchedexponential diffusion-weighted imaging(dWI)models in distinguishing between benign and malignant hepatic lymph nodes in patients with CrLM who received neoadjuvant chemotherapy prior to *** In this retrospective study,97 CrLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging,including dWI with ten b values before and after *** parameters,such as the apparent diffusion coefficient from the mono-exponential model,and the true diffusion coefficient,the pseudo-diffusion coefficient,and the perfusion fraction derived from the intravoxel incoherent motion model,along with distributed diffusion coefficient(ddC)andαfrom the stretched-exponential model(SEM),were *** parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups.A nomogram was constructed to predict the hepatic lymph node *** reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation *** Multivariate analysis revealed that the pre-treatment ddC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes.A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CrLM patients,with an area under the curve of ***,parameters from SEM sho

关键词： Colorectal cancer Individualized treatment diffusion magnetic resonance imaging Intravoxel incoherent motion Liver

Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell rNA-sequencing and spatial transcriptomics

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Protein & Cell 2024年第7期15卷 530-546页

作者： Tao Chen Yiliang Xu Xiaocui Xu Jianzhang Wang Zhiruo Qiu Yayuan Yu Xiaohong Jiang Wanqi Shao dandan Bai Mingzhu Wang Shuyan Mei Tao Cheng Li Wu Shaorong Gao Xuan Che department of Obstetrics and Gynecology Affiliated Women and Children Hospital of Jiaxing UniversityJiaxing 314000China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Key Laboratory of Animal Bioengineering and disease Prevention of Shandong Province College of Animal Science and TechnologyShandong Agricultural UniversityTaian 271018China Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310013China Postgraduate training base Alliance of Wenzhou Medical University Wenzhou Medical UniversityWenzhou 325035China Jiaxing University Master degree Cultivation base Zhejiang Chinese Medical UniversityHangzhou 310053China Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal-Fetal Medicine and Gynecologic OncologyClinical and Translational Research CenterShanghai First Maternity and Infant HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Adenomyosis is a poorly understood gynecological disorder lacking effective *** persists regarding“invagination”and“metaplasia”*** endometrial-myometrial junction(EMJ)connects the endometrium and myometrium and is important for diagnosing and classifying adenomyosis,but its in-depth study is just *** single-cell rNA sequencing and spatial profiling,we mapped transcriptional alterations across eutopic endometrium,lesions,and *** lesions,we identified unique epithelial(LGr5+)and invasive stromal(PKIB+)subpopulations,along with WFdC1+progenitor cells,supporting a complex interplay between“invagination”and“metaplasia”theories of ***,we observed endothelial cell heterogeneity and abnormal angiogenic signaling involving vascular endothelial growth factor and angiopoietin ***-cell communication differed markedly between ectopic and eutopic endometrium,with aberrant signaling in lesions involving pleiotrophin,TWEAK,and WNT *** study reveals unique stem cell-like and invasive cell subpopulations within adenomyosis lesions identified,dysfunctional signaling,and EMJ abnormalities critical to developing precise diagnostic and therapeutic strategies.

关键词： adenomyosis single-cell rNA sequencing spatial transcriptomics endometrial-myometrial junction progenitor cells