BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response
作者机构：Guangdong Key Laboratory of Genome Instability and Human Disease PreventionDepartment of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhenGuangdong 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D CenterInternational Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay LaboratoryShenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical EngineeringShenzhen University School of MedicineShenzhenGuangdong 518055China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第1期
页 面：19-22页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Key R&D Program of China(No.2017YFA0503900) the National Natural Science Foundation of China(No.32090033,81720108027,81530074,82103275,82002986) the Science and Technology Program of Guangdong Province in China(No.2017B030301016) China Postdoctoral Science Foundation(No.2019M663092) Basic and Applied Basic Research Foundation of Guangdong Province(No.2019A1515110039,2019A1515110041,2021A1515011126) Shenzhen Municipal Commission of Science and Technology Innovation(China)(No.JCYJ20170818092450901,JCYJ20200109114214463)
摘 要：Etoposide is widely used for cancer chemotherapy in the ***,long-term etoposide treatment can lead to adverse effects or drug *** improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer ***,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway.
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