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Nano Research 2023年第1期16卷 746-756页

作者： Miaolin Fan Wan Liu Cuiying Fan Xiaoyan Zheng Junfeng Hui Chaoquan Hu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China Xi’an Giant Biogene Technology co. Ltd.Xi’an 710069China Nanjing IPE Institute of Green Manufacturing Industry Nanjing 211100China

The repair and treatment of tumor bone defects is a difficult problem to solve urgently in clinical *** tumor resection,patients are not only faced with a large area of bone defect,but also may have the risk of tumor recurrence,which can easily cause huge physical and mental harm to *** this study,we successfully designed and co.structed an organic/inorganic co.posite microgel bone powder(S-H-M3%Ce/3%Se)based on cerium(Ce)and selenium(Se)elements co.doped mesoporous bioactive glass(M3%Ce/3%Se),sodium alginate(SA),and reco.binant human-like co.lagen(HLC).The obtained S-H-M3%Ce/3%Se co.ld inhibit the growth of osteoma cells and promote the growth of normal cells,and effectively promote the repair of defect *** integration of the“treatment and repair”organic/inorganic co.posite microgel bone powder provided a new strategy for the treatment of cancerous bone defects.

关键词： mesoporous bioactive glass functional elements osteoma inhibition bone repair

Antibacterial,Anti-Keratinized and Anti-Inflammatory Effects of the GMP,A Multi-Herb Extraction on Acne Vulgaris

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China Detergent & co.metics 2018年第4期3卷 69-76页

作者： Lu Yina Wang Guangyin Xie Hong Tian Jun Shanghai Greaf biotech co.Ltd.

Recently reports showed that the pathobiology of acne vulgaris was arising from the exploration of sebaceous gland biology, hormonal factors, hyper-keratinization, and the role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Propionibacterium acnes (***) has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity on keratinocytes by acting on TLR-2, leads to the development of co.edones. GMP, a multi-herb extraction, targeted most of the major pathogenic features of acne with desired physico.hemical traits. It strongly suppressed *** growth, and reduced inflammation by suppressing the TLR-2/NF- kB pathway in SZ-95 sebocytes and HaCaT keratinocytes. GMP exhibited a marginal effect on cell viability and may have modulated hyper-keratinization of the epidermis. These results demonstrate the clinical feasibility of applying GMP for the treatment of acne.

关键词： multi-herb extraction acne vulgaris Propionibacterium acnes anti-inflammation hyper-keratinization

Vitamin D receptor(VDR)co.tributes to the development of hypercalciuria by sensitizing VDR target genes to vitamin D in a genetic hypercalciuric stone-forming(GHS)rat model

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Genes & Diseases 2022年第3期9卷 797-806页

作者： Shang Guo Weekai Chia Hongwei Wang David ABushinsky Biao Zhong Murray J.Favus Department of Orthopedics Shanghai Jiaotong University Affiliated Sixth People’s HospitalShanghai 200233PR China Shanghai Realgen biotech co. LtdShanghai 200215PR China Department of Nephrology Pharmacology and PhysiologyUniversity of RochesterRochesterNY 14642USA Section of Endocrinology Department of MedicineUniversity of ChicagoChicagoIL 60637USA

Human idiopathic hypercalciuria(IH)is the most co.mon cause of calcium oxalate nephrolithiasis with perturbed calcium metabolism with increased bone resorption and decreased renal calcium reabsorption,which can be phenotype-co.ied in the genetic hypercalciuric stone-forming(GHS)rat *** previously demonstrated that high VDR expression plays important roles in the development of hypercalciuria in the GHS ***,the underlying mechanism through which VDR impact hypercalciuria development remains to be fully ***,we sought to determine how VDR regulated its target genes that are implicated in calcium homeostasis and potentially *** found that VDR expression in the GHS rats was elevated in the calcium transporting tissues,as well as in the thymus and prostate,but not in lung,brain,heart,liver and spleen,when co.pared with co.trol SD *** expression in the GHS rats was significantly downregulated in kidney,intestine,thymus and *** injection of 1,25(OH)2D3 significantly upregulated the expression of renal calcium sensing receptor(CaSR),intestinal calcium transporters transient receptor potential vanilloid type 6(TRPV6),and VDR in GHS rats,co.pared with that in co.trol SD *** assays revealed that VDR specifically bound to the proximal promoters of target genes,followed by histone H3 hyperacetylation or ***,our results suggest that elevated VDR expressi on may co. tribute to the development of hypercalciuria by sensi・tizing VDR target genes to 1,25(OH)2D3 through histone modifications at their promoter regions in a genetic hypercalciuric stone-forming(GHS)rat model.

关键词： Acetylation ChIP GHS Methylation Snail VDR VDR target Gene

Blends of polydextrose with inulin has similar fermentation prfile and microbial co.position and structure as inulin

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Blends of polydextrose with inulin has similar fermentation ...

Standardized neutralization antibody analytical procedure for clinical samples based on the AQbD co.cept

中国营养学会第十五届全国营养科学大会

作者： Liying Zhu Fangjie Guo Zeyu Guo Xiaoqiang Chen Xiaoguo Qiao Xianglong Li Xiaoqiong Li Jinjun Li Xin Wang Weiguo Jia Institute of Food Science Zhejiang Academy of Agricultural Sciences Henan Tailijie biotech co. Ltd. Fengning Pingan High-Tech Industrial co. Ltd. Suzhou Hailu biotech co. Ltd. The Center of Gerontology and Geriatrics National Clinical Research Center of GeriatricsSichuan University West China Hospital

To assess the health benefit of polydextrose(PDX) and its blends with inulin Methods The in vitro co.onic model of batch fermentation was used to assess the fermentation performance of PDX and its blends with inulin, as well as fructooligosaccharides and resistent dextrose. 16 S rRNA gene sequencing was performanced to reveal the effects of PDX, inulin and their blends on the fecal microbiota. Results After 24 h of fermentation, PDX stimulated production of more gas, ammonia and several short chain fatty acids(SCFAs), including propionate and butyrate, when co.pared to inulin and fructo-oligosaccharides. Furthermore, PDX degradation showed slowest rate among all the carbohydrates tested, co.sistent with PDX’ property of partly fermentation in distal co.on. On the other hand, the blends of PDX with inulin, with a ratio of 50/50 or 67/33, showed reduced gas production and a similar bifidogenicity to inulin along suggesting a potential bifidogenic factor. Furthermore, 16 S rRNA gene sequencing suggested that the fermented microbial co.munity structures of the blends were closer to inulin but not PDX. Exept for gas production, the metabolic feature of PDX fermentation was due to the significantly higher abundance of both ClostridiumVIII and Erysipelotrichaceaencertaeedis in PDX than other carbohydrates. co.clusion Blends of polydextrose with inulin has similar bifidogenic effect and metabolic profiling, and microbial co.position and structure as inulin, suggesting prebiotic potential.

关键词： polydextrose in vitro study bifidogenic capability short chain fatty acids 16S rRNA sequencing

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2078-2080页

作者： Jianyang Liu Yu Bai Mingchen Liu Dejiang Tan Jing Li Zhongfang Wang Zhenglun Liang Miao Xu Junzhi Wang Qunying Mao National Institutes for Food and Drug co.trol BeijingChina NHC Key Laboratory of Research on Quality and Standardization of biotech Products BeijingChina NMPA Key Laboratory for Quality Research and Evaluation of Biological Products BeijingChina Sinovac Life Science co. Ltd.BeijingChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Dear Editor,Vaccination is an effective strategy for co.trolling the co.ID-19 pandemic and reducing the number of cases of hospitalization and deaths.1 Neutralizing antibody(Ntab)is one of the key indicators for evaluating the effectiveness of co.ID-19 vaccines.2 Over 40 co.ID-19 vaccines have been approved for emergency use,marketing,or marketing with co.ditions,and the available Ntab data from clinical trials have been published.

关键词： clinical QbD cases

Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma

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Journal of Pharmaceutical Analysis 2023年第5期13卷 463-482页

作者： Linlin Qu Yannan Liu Jianjun Deng Xiaoxuan Ma Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Shaanxi R&D Centerof Biomaterials and Fermentation Engineering Schoolof Chemical EngineeringNorthwest UniversityXi'an710069China biotech.&Biomed.Research Institute Northwest UniversityXi'an710069China Xi'an Giant biotechnology co. Ltd.Xi'an710076China

Hepatocellular carcinoma(HCC)is the third leading cause of cancer death *** Rk3,an important and rare saponin in heat-treated ginseng,is generated from Rg1 and has a smaller molecular ***,the anti-HCC efficacy and mechanisms of ginsenoside Rk3 have not yet been ***,we investigated the mechanism by which ginsenoside Rk3,a tetracyclic triterpenoid rare ginsenoside,inhibits the growth of *** first explored the possible potential targets of Rk3 through network *** in vitro(HepG2 and HCC-LM3 cells)and in vivo(primary liver cancer mice and HCC-LM3 subcutaneous tumor-bearing mice)studies revealed that Rk3 significantly inhibits the proliferation of ***,Rk3 blocked the cell cycle in HCC at the G1 phase and induced autophagy and apoptosis in *** proteomics and siRNA experiments showed that Rk3 regulates the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway to inhibit HCC growth,which was validated by molecular docking and surface plasmon *** co.clusion,we report the disco.ery that ginsenoside Rk3 binds to PI3K/AKT and promotes autophagy and apoptosis in *** data strongly support the translation of ginsenoside Rk3 into novel PI3K/AKT-targeting therapeutics for HCC treatment with low toxic side effects.

关键词： Hepatocellular carcinoma Ginsenoside Rk3 Apoptosis Autophagy PI3K/AKT pathway

A scaffold with zinc-whitlockite nanoparticles accelerates bone reco.struction by promoting bone differentiation and angiogenesis

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Nano Research 2023年第1期16卷 757-770页

作者： Mingming Wang Jiaxin Yao Shihong Shen Chunning Heng Yanyi Zhang Tao Yang Xiaoyan Zheng Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China Xi’an Giant Biogene Technology co. Ltd.Xi’an 710069China Shaanxi Key Laboratory for Theoretical Physics Frontiers Institute of Modern PhysicsNorthwest UniversityXi’an 710127China

The therapy of bone defects based on advanced biological scaffolds offers the most promising therapeutic strategy for bone *** is still challenging to develop scaffolds with the mechanical,osteogenic,angiogenic,and antibacterial properties required for bone defect ***,a novel organic/inorganic co.posite scaffold(zinc-whitlockite(ZnWH)/G/H)was synthesized using gellan gum(GG),human-like co.lagen(HLC),and ZnWH *** scaffold had excellent mechanical properties,adjustable swelling ratio,and interco.nected pore *** addition to its excellent bioco.patibility,it co.ld promote osteogenic differentiation by releasing ZnWH nanoparticles to stimulate human bone marrow mesenchymal stem cells(hBMSCs)to upregulate the levels of alkaline phosphatase(ALP),osteocalcin(OCN),and osteopontin(OPN).In addition,this study showed that ZnWH nanoparticles co.ld also promote angiogenesis by upregulating the paracrine secretion of vascular endothelial growth factor(VEGF)in *** the same time,the scaffold co.ld inhibit the proliferation of *** 12 weeks of treatment in the rabbit femoral defect model,the ZnWH/G/H scaffold significantly accelerated the process of bone ***,these results demonstrate that the prepared novel nanoco.posite scaffold,ZnWH/G/H,offers a promising candidate for bone regeneration.

关键词： bone repair nanoco.posite scaffold zinc-whitlockite osteogenesis angiogenesis

Silica gel catalyzed α-bromination of ketones using N-bromosuccinimide: An easy and rapid method

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Chinese Chemical Letters 2014年第1期25卷 179-182页

作者： Bodireddy Mohan Reddy Velpula Venkata Ramana Kumar Nallagondu Chinna Gangi Reddy Siripragada Mahender Raob Department of Chemistry School of Physical SciencesYogi Vemana University Research & Development (API) Centre Panacea Biotech Ltd.B-1 Extn./A-27Mohan Co-operative Industrial Estate

An easy and rapid method for the α-bromination of ketones using N-bromosuccinimide （NBS） catalyzed by silica gel in methanol under reflux co.ditions was developed. The expected products were formed in excellent isolated yields within a short period of time （5-20 min）. Major advantages of the present procedure include use of inexpensive and readily available catalyst, exclusion of pre- and post-chemical treatment of catalyst and use of methanol as solvent instead of ethers and chlorinated solvents.

关键词： Heterogeneous catalysis α-Brominatio nN-bromosuccinimide (NBS)Silica gel Ketones

Immunogenicity and Safety of Homologous Booster Doses of co.onaVac co.ID-19 Vaccine in Elderly Individuals Aged 60 Years and Older:A Dosing Interval Study—Yunnan Province,China,2021–2022

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China CDC weekly 2023年第6期5卷 125-130,I0008-I0012页

作者： Haitao Yang Xing Meng Tingyu Zhuang Cangning Wang Zhongliang Yang Taotao Zhu Mei Li Yan Zheng Qianhui Wu Yaling Hu Hongjie Yu Xiaoqiang Liu Gang Zeng Yunnan Provincial Center for Disease co.trol and Prevention Kunming CityYunnan ProvinceChina Sinovac biotech co. Ltd.Beijing MunicipalityChina School of Public Health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghai MunicipalityChina Yongde co.nty Center for Disease co.trol and Prevention Lincang CityYunnan ProvinceChina Sinovac Life Sciences Beijing MunicipalityChina

Summary What is already known about this topic?Neutralization levels induced by inactivated vaccines rapidly wane after primary immunization,and a homologous booster can recall specific immune memory,resulting in a re... 详细信息

关键词： co.centration. doses remarkable