Ce and Se co-doped MBG/SA/HLC microgel bone powder for repairing tumor bone defects
作者机构：Shaanxi Key Laboratory of Degradable Biomedical MaterialsShaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research InstituteNorthwest UniversityXi’an 710069China Xi’an Giant Biogene Technology Co.Ltd.Xi’an 710069China Nanjing IPE Institute of Green Manufacturing IndustryNanjing 211100China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第1期
页 面：746-756页
核心收录：
学科分类：0710[理学-生物学] 1003[医学-口腔医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(Nos.22078265,21908179,and 21838009) the National key Research and development program of China(No.2021YFC2103900) the Shaanxi Provincial Science Foundation(Nos.2017SF-201 and 218JQ2052)
主 题：mesoporous bioactive glass functional elements osteoma inhibition bone repair
摘 要：The repair and treatment of tumor bone defects is a difficult problem to solve urgently in clinical *** tumor resection,patients are not only faced with a large area of bone defect,but also may have the risk of tumor recurrence,which can easily cause huge physical and mental harm to *** this study,we successfully designed and constructed an organic/inorganic composite microgel bone powder(S-H-M3%Ce/3%Se)based on cerium(Ce)and selenium(Se)elements co-doped mesoporous bioactive glass(M3%Ce/3%Se),sodium alginate(SA),and recombinant human-like collagen(HLC).The obtained S-H-M3%Ce/3%Se could inhibit the growth of osteoma cells and promote the growth of normal cells,and effectively promote the repair of defect *** integration of the“treatment and repairorganic/inorganic composite microgel bone powder provided a new strategy for the treatment of cancerous bone defects.
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