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Spontaneous Rabies in a Stray Bitch after Parturition Induced Immunosuppression —Investigating an Impending Outbreak of Rabies with One Health Approach

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World Journal of Vaccines 2016年第1期6卷 1-8页

作者： Omesh Kumar Bharti Hamender Sharma Uppinder Sharma Archana Phull state intradermal antirabies clinic and research centre DDU Hospital Shimla Shimla India Dog Sterilization centre Animal Birth Control Programme MC Shimla Shimla India Veterinary Hospital Kangra India Daily Post Shimla India

Background: Rabies is endemic in India and every half an hour a person dies of this dreaded disease. Stray roaming dogs, mostly unvaccinated, are most dangerous host in spread of rabies in India and in our state of Himachal Pradesh. Timely prophylaxis is the only method to save animal bite victims, including that of rabid dog bite patients. Objectives: Objective of this study was to investigate an impending outbreak of rabies in Shimla town in the absence of life saving rabies immunoglobulins (RIGs) in the market, and to know the source of infection by using one health approach and using epidemiological tools. Methods: On April 7, 2015, there was a sudden surge in cases of suspected rabid dog bites. Impending rabies outbreak was suspected as there were no RIGs available in the market. A rapid Response Team (RRT) consisting of the author, veterinary doctor, dog squad of Municipal Corporation (MC) Shimla along with the vehicles to impound rabid dogs was constituted to investigate the terror spread by two rabid dogs on biting spree in the Shimla Municipality. Results: A total of 18 people were bitten by suspected rabid dogs within three days period. A black bitch and a brown dog, on the identity of affected people, were captured by the dog squad of Municipality next day on April 8, 2015 and taken to Dog Sterilization centre, Animal Birth Control (ABC) programme, MC Shimla for observation. The most furious Black bitch died of clinically confirmed symptoms of furious rabies after three days. The second rabid dog, brown in color, died after a month of observation due to paralytic dumb rabies. The brain of the brown dog was extracted for Fluorescent Antibody Testing (FAT) at central research Institute (CRI) Kasauli and was found to be positive for FAT. Follow up of patients was 100% by house to house visit and over telephone and no casualty was reported. Conclusion: While we were working on hypothesis of rabid dogs getting the infection from nearby forest about 8 - 10 KM a

关键词： Human Rabies Dog Rabies Rabies Outbreak Local Rabies Immunoglobulins Anti Rabies Vaccination Immunosuppression FAT Testing ONE Health

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Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer:A retrospective analysis

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World Journal of Experimental Medicine 2024年第1期14卷 44-57页

作者： Marina A Senchukova Evgeniy A Kalinin Nadezhda N Volchenko Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia Department of Thoracic Surgery Orenburg Regional Cancer ClinicOrenburg 460021Russia Department of Pathology P.A.Hertzen Moscow Oncology Research CentreNational Medical Research Centre of RadiologyMoscow 125284Russia

BACKGROUND Lung cancer(LC)is a global medical,social and economic problem and is one of the most common cancers and the leading cause of mortality from malignant *** is characterized by an aggressive course,and in the presence of disease recurrence risk factors,patients,even at an early stage,may be indicated for adjuvant therapy to improve ***,combined treatment does not always guarantee a favorable *** this regard,establishing predictors of LC recurrence is highly important both for determining the optimal treatment plan for the patients and for evaluating its *** To establish predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa lung squamous cell carcinoma(LSCC).METHODS A retrospective case-control cohort study included 69 patients with LSCC who underwent radical surgery at the Orenburg Regional clinical Oncology Center from 2009 to ***,all patients received adjuvant *** samples of the resected lung were stained with Mayer's hematoxylin and eosin and examined under a light *** and multivariate analyses were used to identify predictors associated with the risk of disease *** operating characteristic curves were constructed to discriminate between patients with a high risk of disease recurrence and those with a low risk of disease *** was analyzed using the Kaplan-Meier *** log-rank test was used to compare survival curves between patient *** were considered to be significant at P<*** The following predictors of a high risk of disease recurrence in patients with stage IIb-IIa LSCC were established:a low degree of tumor differentiation[odds ratio(OR)=7.94,95%CI=1.08-135.81,P=0.049];metastases in regional lymph nodes(OR=5.67,95%CI=1.09-36.54,P=0.048);the presence of loose,fine-fiber connective tissue in the tumor stroma(OR=21.70,95%CI=4.27-1

关键词： Lung cancer Lung squamous cell carcinoma Adjuvant chemotherapy Radical resection Disease recurrence risk factors

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Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

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International Journal of Oral Science 2021年第1期13卷 17-32页

作者： Bowen Tan Quan Tang Yongjin Zhong Yali Wei Linfeng He Yanting Wu Jiabao Wu Jinfeng Liao state Key Laboratory of Oral Diseases&National clinical research centre for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina

Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone *** traditional tumour therapy,the systemic toxicity of chemotherapeutic drugs,invasive surgical resection,intractable tumour recurrence,and metastasis are major threats to the patients’lives in the ***,biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis,suggesting new promising antitumour *** addition,maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients,and investment in treatment can result in a multitude of burdens to *** are promising options because they have good biocompatibility and bioactive properties for stimulation of bone *** interestingly,an integrated material regimen that combines tumour therapy with bone repair is a promising treatment ***,we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect ***,we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.

关键词： tumour maxillofacial defect

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Does energy policy uncertainty matter for renewable energy and energy efficiency technologies?An affordable and clean energy perspective

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Geoscience Frontiers 2024年第6期15卷 516-527页

作者： Ugur Korkut Pata Department of Economics College of Political Science and EconomicsKorea UniversitySeoul 02481South Korea Department of Economics Hatay Mustafa Kemal UniversityHatayTürkiye clinic of Economics Azerbaijan State University of Economics(UNEC)BakuAzerbaijan Advance research centre European University of LefkeLefkeNorthern CyprusTR-10 MersinTürkiye Economic research Center(WCERC) Western Caspian UniversityBakuAzerbaijan

Uncertainty can affect both macroeconomic indicators and the *** are implementing various energy policies to combat global warming,but these policies contain some uncertainties and *** environmental impact of uncertainties in energy policies is a research topic that has just begun to be investigated by *** study examines the effects of energy policy uncertainty(ENERPU)on renewable energy R&D(RR&D),energy efficiency R&D(EER&D)and renewable energy consumption in the four countries with the highest RR&D expenditures(USA,Germany,Japan,and Spain).The study uses the novel multivariate quantile-on-quantile(M-QQR)approach from 2003m1 to *** results of the study show:(i)The impact of ENERPU varies by quantile and country.(ii)ENERPU causes a decrease in renewable energy consumption and hinders RR&D expenditures.(iii)ENERPU increases EER&*** Fourier quantile causality test confirms the robustness of the empirical *** on these findings,policymakers are recommended to minimize ENERPU and implement stable energy policies to develop the renewable energy sector and technologies.

关键词： Energy policy uncertainty Energy technologies Renewable energy Multivariate quantile approach

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Review of a new bone tumor therapy strategy based on bifunctional biomaterials

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Bone research 2021年第2期9卷 153-165页

作者： Jinfeng Liao Ruxia Han Yongzhi Wu Zhiyong Qian state Key Laboratory of Oral Diseases National Clinical Research Centre for Oral DiseasesState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityChengduSichuanP.R.China

Bone tumors,especially those in osteosarcoma,usually occur in *** standard clinical treatment includes chemotherapy,surgical therapy,and radiation ***,surgical resection often fails to completely remove the tumor,which is the main cause of postoperative recurrence and metastasis,resulting in a high mortality ***,bone tumors often invade large areas of bone,which cannot repair itself,and causes a serious effect on the quality of life of ***,bone tumor therapy and bone regeneration are challenging in the ***,this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor *** selected bifunctional materials include 3D-printed scaffolds,nano/microparticle-containing scaffolds,hydrogels,and bone-targeting *** related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were ***,a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is *** review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

关键词： biomaterials chemotherapy mortality

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Exploring the Feasibility of a New Low Cost Intra-Dermal Pre &Post Exposure Rabies Prophylaxis Protocol in Domestic Bovine in Jawali Veterinary Hospital, District Kangra, Himachal Pradesh, India

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World Journal of Vaccines 2018年第1期8卷 8-20页

作者： Omesh Kumar Bharti Uppinder Kumar Sharma Adarsh Kumar Archana Phull Intra-Dermal antirabies clinic and research centre DDU Hospital Shimla Himachal Pradesh India Sub Divisional Hospital Jawali Kangra Himachal Pradesh India Department of Surgery and Radiology College of Veterinary and Animal Sciences CSK Agricultural University Palampur Himachal Pradesh India Department of Journalism Himachal Pradesh India

Cattle are the backbone of household economy in rural areas of India and many of them die after bites by potentially rabid dogs, despite being given currently recommended five shots of intramuscular (IM) rabies vaccination as Post Exposure Prophylaxis (PEP). In 2016, seven of 21 bovine bitten by rabid dogs given IM rabies vaccination died due to rabies in Shimla Municipality. This scenario prompted the authors to look for a suitable protocol, based on human studies, to save animals. We tested various schedules of IDRV in bovine and found that a schedule of 0.2 ml given in middle 1/3rd of neck on day 0, 3, 7, 14 and 28 along with local wound infiltration of eRIG is sufficiently immunogenic and life saving in all of them, even if bitten by lab confirmed rabid dogs/mongoose as tested by CRI. Rabivac Vet, a Cell Culture Rabies Vaccine, available as 1 ml per vial was used off level for IDRV. While injecting the vaccine, a raised papule of ≥1 cm will appear slowly causing a peau d’orange appearance. All 60 bovine serum samples tested by RFFIT after IDRV, had titers more than 0.5 IU/ml on day 14. Thereafter, a total of 150 animals were given five doses of IDRV as PEP, with or without RIG, after their exposure to clinically or lab confirmed rabid dogs/mongoose and all survived for more than a year. Serum samples from 15 animals bitten by lab confirmed rabid dogs/mongoose were collected on day 14 and tested for RVNA by RFFIT from NIMHANS Bangalore and all had desired antibody titers above 0.5 IU/ml, without any immunosuppression. The RFFIT titers in 55% bovine in all groups were more than adequate after one year and 100% of them had anamnestic response to a single 0.2 ml booster given at one year. Few of the bovine and even one equine (Horse. Figure 4) brought for PEP at some of nearby vet hospitals were given IM rabies vaccine with local eRIG infiltration also survived. Local eRIG infiltration appeared to have covered the lacuna of longer window period required for indigeno

关键词： Rabies Local Wound Infiltration of Rabies Immunoglobulin Intra-Dermal Rabies Vaccination

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Animal models of atherosclerosis

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World Journal of clinical Cases 2014年第5期2卷 126-132页

作者： Fatemeh Ramezani Kapourchali Gangadaran Surendiran Li Chen Elisabeth Uitz Babak Bahadori Mohammed H Moghadasian International Nutrition research Inc. WinnipegMB R3T2G4Canada Department of Human Nutritional Sciences and Canadian centre for Agri-food research in Health and Medicine St.Boniface Hospital Research Centre and University of ManitobaWinnipegMB R2H 2A6Canada College of Food Science and Technology Huazhong Agricultural University Canadian centre for Agri-food research in Health and Medicine St.Boniface Hospital Research CentreWinnipegMB R2H 2A6Canada Karl Landsteiner Private University of Health and Life Sciences State Clinic St.PoeltenDepartment of Internal Medicine 23100St.PoeltenAustria

In this mini-review several commonly used animal models of atherosclerosis have been *** them,emphasis has been made on mice,rabbits,pigs and non-human *** these animal models have played a significant role in our understanding of induction of atherosclerotic lesions,we still lack a reliable animal model for regression of the *** have reported several genetically modified and transgenic animal models that replicate human atherosclerosis,however each of current animal models have some *** these animal models,the apolipoprotein(apo) E-knockout(KO)mice have been used extensively because they develop spontaneous ***,atherosclerotic lesions developed in this model depending on experimental design may resemble humans' stable and unstable atherosclerotic *** mouse model of hypercholesterolemia and atherosclerosis has been also used to investigate the impact of oxidative stress and inflammation on *** density lipoprotein(LDL)-r-KO mice are a model of human familial ***,unlike apo E-KO mice,the LDL-r-KO mice do not develop spontaneous *** apo E-KO and LDL-r-KO mice have been employed to generate other relevant mouse models of cardiovascular disease through breeding *** addition to mice,rabbits have been used extensively particularly to understand the mechanisms of cholesterol-induced *** present review paper details the characteristics of animal models that are used in atherosclerosis research.

关键词： Atherosclerosis Dyslipidemia Disease Animal models

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Microbiota and viral hepatitis:state of the art of a complex matter

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World Journal of Gastroenterology 2021年第33期27卷 5488-5501页

作者： Ivana Milosevic Edda Russo Ankica Vujovic Aleksandra Barac Olja Stevanovic Stefano Gitto Amedeo Amedei clinic for Infectious and Tropical Diseases Clinical Centre of Serbia Faculty of MedicineUniversity of BelgradeBelgrade 101801Serbia Department of Experimental and clinical Medicine University of FlorenceFirenze 50100Italy

Changes in gut microbiota influence both the gut and liver,which are strictly connected by the so-called“gut-liver axis”.The gut microbiota acts as a major determinant of this relationship in the onset and clinical course of liver *** to the results of several studies,gut dysbiosis is linked to viral hepatitis,mainly hepatitis C virus and hepatitis B virus *** bacteriaderived metabolites and cellular components are key molecules that affect liver function and modulate the pathology of viral *** studies showed that the gut microbiota produces various molecules,such as peptidoglycans,lipopolysaccharides,DNA,lipoteichoic acid,indole-derivatives,bile acids,and trimethylamine,which are translocated to the liver and interact with liver immune cells causing pathological ***,the existence of crosstalk between the gut microbiota and the liver and its implications on host health and pathologic status are essential factors impacting the etiology and therapeutic *** mechanisms behind the pathogenic role of gut-derived components on the pathogenesis of viral hepatitis remain unclear and not *** this review,we discuss the current findings of research on the bidirectional relationship of the components of gut microbiota and the progression of liver diseases and viral hepatitis and vice ***,this paper highlights the current therapeutic and preventive strategies,such as fecal transplantation,used to restore the gut microbiota composition and so improve host health.

关键词： Gut microbiota Hepatitis B virus Hepatitis C virus Liver diseases,Fecal transplantation

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Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第1期11卷 17-21页

作者： Krystyna Stec-Michalska Slawomir Antoszczyk Grazyna Klupinska Barbara Nawrot clinic of Gastroenterology and Internal Diseases centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences

AIM: To answer the question whether FHIT gene expression is affected by the family history of gastric carcinoma and the presence of Helicobacter pylori (Hpylori) in the gastric mucosa of patients with ***: FHIT gene expression in two different topographic sites of the gastric mucosa of twenty-one patients with dyspepsia and with or without familial gastric carcinoma, infected or not infected with H pylori, was evaluated by reverse transcription-PCR (RT-PCR) and IMAGE QUANT methods. A rapid urease test and histopathological examination were used to determine H pylori ***: In the gastric mucosa of patients with family histories of gastric carcinoma, the amount of FHIT protein mRNA was reduced down to 32%, and for patients with H pylori colonization, to 24% in comparison to controls with dyspepsia and without cancer in the family. FHIT expression was independent of the topography of specimens (corpus vsantrum), and for the control patients it was less sensitive to infection with H pylori. A considerable statistical difference in FHIT levels was observed in the gastric mucosa from the corpus of patients with family histories of gastric carcinoma in respect to H pylori colonization (P = 0.06). Macroscopic evaluation of the gastric mucosa demonstrated that pathologic changes classified according to the Sydney system had no significant influence on FHIT expression within each tested group of ***: Loss of FHIT expression was observed in patients with dyspepsia and family histories of gastric carcinoma, especially those infected with H pylori. Such results may constitute an early indication of the development of gastric carcinoma, which is associated with family factors including heredity and H pylori infection. The loss of the FHIT gene may serve as a marker for early diagnosis and prevention of gastric carcinoma, especially in context of early monitoring of H pylori infection in individuals with a record of familial stomach ca

关键词： Gastric cancer Helicobacter pylori infection FHIT protein

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Different types of tumor microvessels in stageⅠ-ⅢA squamous cell lung cancer and their clinical significance

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World Journal of clinical Oncology 2024年第5期15卷 614-634页

作者： Marina A Senchukova Evgeniy A Kalinin Nadezhda N Volchenko Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia Department of Thoracic Surgery Orenburg Regional Cancer ClinicOrenburg 460021Russia Department of Pathology PA Hertzen Moscow Oncology Research CentreBranch of National Medical Research Radiological CenterMoscow 125284Russia

BACKGROUND Lung cancer(LC)is the leading cause of morbidity and mortality among malignant *** the diagnosis and treatment of LC remains an urgent task of modern ***,we established that in gastric,breast and cervical cancer,tumor microvessels(MVs)differ in morphology and have different prognostic *** connection between different types of tumor MVs and the progression of LC is not well *** To evaluate the morphological features and clinical significance of tumor MVs in lung squamous cell carcinoma(LUSC).METHODS A single-center retrospective cohort study examined medical records and archival paraffin blocks of 62 and 180 patients with stage I-IIIA LUSC in the training and main cohorts,*** patients underwent radical surgery(R0)at the Orenburg Regional Cancer clinic from May/20/2009 to December/14/*** sections were routinely processed,and routine Mayer's hematoxylin and eosin staining and immunohistochemical staining for cluster of differentiation 34(CD34),podoplanin,Snail and hypoxia-inducible factor-1 alpha were *** morphological features of different types of tumor MVs,tumor parenchyma and stroma were studied according to clinicopathological characteristics and LUSC *** analysis was performed using Statistica 10.0 *** and multivariate logistic regression analyses were performed to identify potential risk factors for LUSC metastasis to regional lymph nodes(RLNs)and disease *** operating characteristic curves were constructed to discriminate between patients with and without metastases in RLNs and those with and without disease *** effectiveness of the predictive models was assessed by the area under the *** was analyzed using the Kaplan-Meier *** log-rank test was used to compare survival curves between patient subgroups.A value of P<0.05 was considered to indicate statistical *** Depending

关键词： Lung cancer Lung squamous cell carcinoma Tumor microvessels Tumor stroma Regional lymph node metastases Disease recurrence Disease prognosis

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